US14_HCMVM
ID US14_HCMVM Reviewed; 310 AA.
AC F5HD92;
DT 18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 23-FEB-2022, entry version 24.
DE RecName: Full=Membrane protein US14;
GN Name=US14;
OS Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX NCBI_TaxID=295027;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT "Genetic content of wild-type human cytomegalovirus.";
RL J. Gen. Virol. 85:1301-1312(2004).
CC -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the cytomegalovirus US12 family. {ECO:0000305}.
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DR EMBL; AY446894; AAR31703.1; -; Genomic_DNA.
DR RefSeq; YP_081599.1; NC_006273.2.
DR PRIDE; F5HD92; -.
DR DNASU; 3077456; -.
DR GeneID; 3077456; -.
DR KEGG; vg:3077456; -.
DR Reactome; R-HSA-9609690; HCMV Early Events.
DR Proteomes; UP000000938; Genome.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE 3: Inferred from homology;
KW Host membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..310
FT /note="Membrane protein US14"
FT /id="PRO_0000416725"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 208..228
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 310 AA; 34297 MW; F56088ED5258B625 CRC64;
METVSTQRET ASSETERTRE AASAETTDAT FRSLEEGSTI SSRYSETAST ASEDAVCWLR
RTAIVMRVYG LLTLETAFSV LISALVWLGY PSLGYECRDD PSPLLLSCTP VLVLGALELT
DHRHPSNGLV FALYVALLSF TTAGLNLCAT APIGVSSLIL TWTLFVACNG VAWEHRLSSV
WRDALFTSTL LTVMVSVLAS TYTWLHKTLL CLYTVFVGCI LAVLFQDVRY IATKMPVSHI
IRSSLVLYAT ETLIYHTTLL MLTPVVWSAR WDQMFSYLAK LGTYHHYRVD NGTLSVILNS
TTATFQSRVA