US15_HCMVM
ID US15_HCMVM Reviewed; 262 AA.
AC F5HFH0;
DT 11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 02-JUN-2021, entry version 21.
DE RecName: Full=Membrane protein US15;
GN Name=US15;
OS Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX NCBI_TaxID=295027;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT "Genetic content of wild-type human cytomegalovirus.";
RL J. Gen. Virol. 85:1301-1312(2004).
CC -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the HHV-5 US12 protein family. {ECO:0000305}.
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DR EMBL; AY446894; AAR31704.1; -; Genomic_DNA.
DR RefSeq; YP_081600.1; NC_006273.2.
DR PRIDE; F5HFH0; -.
DR DNASU; 3077565; -.
DR GeneID; 3077565; -.
DR KEGG; vg:3077565; -.
DR Proteomes; UP000000938; Genome.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR006214; Bax_inhibitor_1-related.
DR Pfam; PF01027; Bax1-I; 1.
PE 3: Inferred from homology;
KW Host membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..262
FT /note="Membrane protein US15"
FT /id="PRO_0000418253"
FT TRANSMEM 46..66
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..128
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 262 AA; 29099 MW; 42103A97A043EC5C CRC64;
MRREKGFQVP TDGTVIYVPP GIQETRLATR SLAWVDCCRV ALHTYGAVGW QLAGLTALLS
AFCYAAPATW FHHSRLCLTE SSPSLVFVIP VTSVIFIHCY ETSHPSNIGV LLFYTLLHVP
PLIVICLCLD GTLVISAALF TLLAFLSCTG VALLAPERTV RRQIVVIHAL ITLTFTAIVV
VILRRGWSWC FKIVLSFSVL ITCLAVSHFH EAALAVRYET PLERALLAAV KVFLSLVFTL
LMVLRIMTLR TFLQTYFSSD KL