ID   US16_HCMVM              Reviewed;         309 AA.
AC   Q6SVZ0; D2K3W1;
DT   11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   23-FEB-2022, entry version 50.
DE   RecName: Full=Protein US16;
GN   Name=US16;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
RN   [2]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=22496217; DOI=10.1128/jvi.06310-11;
RA   Bronzini M., Luganini A., Dell'oste V., De Andrea M., Landolfo S.,
RA   Gribaudo G.;
RT   "The US16 gene of Human cytomegalovirus is required for efficient viral
RT   infection of endothelial and epithelial cells.";
RL   J. Virol. 86:6875-6888(2012).
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}. Host cytoplasm {ECO:0000269|PubMed:22496217}.
CC       Note=Localizes in cytoplasmic assembly compartments but not present in
CC       virions.
CC   -!- SIMILARITY: Belongs to the cytomegalovirus US12 family. {ECO:0000305}.
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DR   EMBL; AY446894; AAR31705.1; -; Genomic_DNA.
DR   RefSeq; YP_081601.1; NC_006273.2.
DR   PRIDE; Q6SVZ0; -.
DR   DNASU; 3077558; -.
DR   GeneID; 3077558; -.
DR   KEGG; vg:3077558; -.
DR   Reactome; R-HSA-9609690; HCMV Early Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR006214; Bax_inhibitor_1-related.
DR   Pfam; PF01027; Bax1-I; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..309
FT                   /note="Protein US16"
FT                   /id="PRO_0000418321"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        128..148
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        154..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        185..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        210..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        245..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   309 AA;  34689 MW;  DB88FE0B1BAF6B94 CRC64;
     MGLRFPTATQ RQIVFRRLFD SGNNDDYDEA AVVAVLGWVH RFEVVVRIAG LLLFQISTAV
     AVLGSFSLVF PTATLKSRPG FPCHVVWAPE VLLLVPVASA LFVYFRYERP VLAQRNRHPR
     CRRPFRQLVL LLAGLLAHIP ALGVTCACQE PREVLTSFVL TLVITLLCAE VVFICRDNCT
     LSDQFALING VWVVVFLANV LIVFTRPWTW PLRLLLGFYS TVGLIFAGHF SQQVLFVRHV
     LMPRDVAHTS LQLFITFISL FFLILRIRNC QDLLSDLRLL ELPSSDAMTL TPNDLSHASS
     STPLSTLSP