ID   US18_HCMVM              Reviewed;         274 AA.
AC   F5HE69;
DT   18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   23-FEB-2022, entry version 23.
DE   RecName: Full=Transmembrane protein US18;
GN   Name=US18;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cytomegalovirus US12 family. {ECO:0000305}.
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DR   EMBL; AY446894; AAR31707.1; -; Genomic_DNA.
DR   RefSeq; YP_081603.1; NC_006273.2.
DR   PRIDE; F5HE69; -.
DR   GeneID; 3077472; -.
DR   KEGG; vg:3077472; -.
DR   Reactome; R-HSA-9609690; HCMV Early Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Host membrane; Late protein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..274
FT                   /note="Transmembrane protein US18"
FT                   /id="PRO_0000416726"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        75..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        168..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        228..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   274 AA;  30194 MW;  253FFEF64DEC721B CRC64;
     MGDTASVSEH HESPTVTIVP LHRSHALVAE QQLFQWLKRF KLLMEVYHGL VWQLACTLTV
     CLLAWLAFPD VQGQCANGIV PALSSIVPVS TLAMLRGFAE FRPHTTNFAH LTVACLLINT
     GITVCTGFCG ERRVIGLSFA LVMVFFVLCS GLTYLAGNNP TRWKVIGIGY GWSVIVFYLL
     LYFSPVLWVS KIYSGLYVLV VTAASAVLIY ETLDLIYQRG TLSKNSVCVS VVLYTIVMSL
     LNMSVAIFSG HVWVQQYAEK HGGRIDGVSL LSLL