ID   US18_HCMVT              Reviewed;         274 AA.
AC   P69335; P09726;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   02-DEC-2020, entry version 40.
DE   RecName: Full=Transmembrane protein HWLF5;
GN   Name=US18;
OS   Human cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10363;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8383226; DOI=10.1128/jvi.67.4.2043-2054.1993;
RA   Guo Y.-W., Huang E.S.;
RT   "Characterization of a structurally tricistronic gene of human
RT   cytomegalovirus composed of U(s)18, U(s)19, and U(s)20.";
RL   J. Virol. 67:2043-2054(1993).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cytomegalovirus US12 family. {ECO:0000305}.
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DR   EMBL; L04998; AAA45991.1; -; Genomic_DNA.
DR   PIR; B27231; QQBEG2.
DR   RefSeq; YP_081603.1; NC_006273.2.
DR   TCDB; 1.A.14.4.3; the calcium transporter a (cata) (formerly the testis-enhanced gene transfer (tegt) family.
DR   GeneID; 3077472; -.
DR   KEGG; vg:3077472; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Late protein; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..274
FT                   /note="Transmembrane protein HWLF5"
FT                   /id="PRO_0000115278"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        75..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        168..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        228..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   274 AA;  30194 MW;  253FFEF64DEC721B CRC64;
     MGDTASVSEH HESPTVTIVP LHRSHALVAE QQLFQWLKRF KLLMEVYHGL VWQLACTLTV
     CLLAWLAFPD VQGQCANGIV PALSSIVPVS TLAMLRGFAE FRPHTTNFAH LTVACLLINT
     GITVCTGFCG ERRVIGLSFA LVMVFFVLCS GLTYLAGNNP TRWKVIGIGY GWSVIVFYLL
     LYFSPVLWVS KIYSGLYVLV VTAASAVLIY ETLDLIYQRG TLSKNSVCVS VVLYTIVMSL
     LNMSVAIFSG HVWVQQYAEK HGGRIDGVSL LSLL