ID   US19_HCMVM              Reviewed;         240 AA.
AC   F5HAR3;
DT   18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   23-FEB-2022, entry version 24.
DE   RecName: Full=Transmembrane protein US19;
GN   Name=US19;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: Expressed 34 hours post-infection.
CC   -!- SIMILARITY: Belongs to the cytomegalovirus US12 family. {ECO:0000305}.
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DR   EMBL; AY446894; AAR31708.1; -; Genomic_DNA.
DR   RefSeq; YP_081604.1; NC_006273.2.
DR   PRIDE; F5HAR3; -.
DR   DNASU; 3077522; -.
DR   GeneID; 3077522; -.
DR   KEGG; vg:3077522; -.
DR   Reactome; R-HSA-9609690; HCMV Early Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Host membrane; Late protein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..240
FT                   /note="Transmembrane protein US19"
FT                   /id="PRO_0000416727"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        64..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   240 AA;  26413 MW;  B9D78CD10E27F494 CRC64;
     MLHVVPLEWT VEEVVPYLER LAVWLRASVL VAFQLTATVA LSVLSWWLMP PPVAELCERG
     RDDDPPSLSH LSLVVPVGCL FLLLRGPSID RCPRKLPLLL AYCLPHALAF LTLLMCQPSP
     QAFVGAALLA LAVDLSCLGA SLLGCDPGAS LRRLWLPSVL SLLCATALGL WLLRAAAPFF
     LGLHATTLLT VTLMLIHDLS LITCQSSFPE SFQPSLRLYV ENVALFIGMY HLLRLWLWSP