ID   US19_HCMVT              Reviewed;         240 AA.
AC   P69337; P09725;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   02-DEC-2020, entry version 36.
DE   RecName: Full=Transmembrane protein HWLF4;
GN   Name=US19;
OS   Human cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10363;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8383226; DOI=10.1128/jvi.67.4.2043-2054.1993;
RA   Guo Y.-W., Huang E.S.;
RT   "Characterization of a structurally tricistronic gene of human
RT   cytomegalovirus composed of U(s)18, U(s)19, and U(s)20.";
RL   J. Virol. 67:2043-2054(1993).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: Expressed 34 hours post-infection.
CC   -!- SIMILARITY: Belongs to the cytomegalovirus US12 family. {ECO:0000305}.
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DR   EMBL; L04998; AAA45990.1; -; Genomic_DNA.
DR   PIR; C27231; QQBEG3.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Late protein; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..240
FT                   /note="Transmembrane protein HWLF4"
FT                   /id="PRO_0000115280"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        64..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        154..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   240 AA;  26423 MW;  F5293843454BF8A5 CRC64;
     MLHVVPLEWT VEEVVPYLER LAVWLRASVL VAFQLTATVA LSVLSWWLMP PPVAELCERG
     RDDDPPPLSH LSLVVPVGCL FLLLRGPSID RCPRKLPLLL AYCLPHALAF LTLLMCQPSP
     QAFVGAALLA LAVDLSCLGA SLLGCDPGAS LRRLWLPSVL SLLCATALGL WLLRAAAPFF
     LGLHATTLLT VTLMLIHDLS LITCQSSFPE SFQPSLRLYV ENVALFIGMY HLLRLWLWSP