US20_HCMVA
ID US20_HCMVA Reviewed; 342 AA.
AC P09724; Q7M6H9;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 4.
DT 23-FEB-2022, entry version 80.
DE RecName: Full=Transmembrane protein HWLF3;
GN Name=US20;
OS Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX NCBI_TaxID=10360;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3031311; DOI=10.1016/0022-2836(86)90359-1;
RA Weston K.M., Barrell B.G.;
RT "Sequence of the short unique region, short repeats, and part of the long
RT repeats of human cytomegalovirus.";
RL J. Mol. Biol. 192:177-208(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=2161319; DOI=10.1007/978-3-642-74980-3_6;
RA Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT "Analysis of the protein-coding content of the sequence of human
RT cytomegalovirus strain AD169.";
RL Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN [3]
RP GENOME REANNOTATION.
RX PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA McGeoch D.J., Hayward G.S.;
RT "The human cytomegalovirus genome revisited: comparison with the chimpanzee
RT cytomegalovirus genome.";
RL J. Gen. Virol. 84:17-28(2003).
RN [4]
RP ERRATUM OF PUBMED:12533697.
RA Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA McGeoch D.J., Hayward G.S.;
RL J. Gen. Virol. 84:1053-1053(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the cytomegalovirus US12 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA35287.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAB37112.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=DAA00209.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; X04650; CAB37112.1; ALT_INIT; Genomic_DNA.
DR EMBL; X17403; CAA35287.1; ALT_INIT; Genomic_DNA.
DR EMBL; BK000394; DAA00209.1; ALT_INIT; Genomic_DNA.
DR PIR; S09934; QQBEG4.
DR RefSeq; YP_081605.1; NC_006273.2.
DR SMR; P09724; -.
DR DNASU; 3077561; -.
DR GeneID; 3077561; -.
DR KEGG; vg:3077561; -.
DR Proteomes; UP000008991; Genome.
DR Proteomes; UP000008992; Genome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR006214; Bax_inhibitor_1-related.
DR Pfam; PF01027; Bax1-I; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Late protein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..342
FT /note="Transmembrane protein HWLF3"
FT /id="PRO_0000115281"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 231..251
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..286
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 296..316
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 21..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 149
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 176
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 330
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
SQ SEQUENCE 342 AA; 38182 MW; 3A5AF6EC9B4535E0 CRC64;
MRVISRARSA CTWTSCTSLS PCSTSCPPSP AAPTLLRRRS LPQQRRRPSS SPNRRVRGVT
TSPCPTRSLV YKRRVGAPQR LCAETVATMQ AQEANALLLS RMEALEWFKK FTVWLRVYAI
FIFQLAFSFG LGSVFWLGFP QNRNFCVENY SFFLTVLVPI VCMFITYTLG NEHPSNATVL
FIYLLANSLT AAIFQMCSES RVLVGSYVMT LALFISFTGL AFLGGRDRRR WKCISCVYVV
MLLSFLTLAL LSDADWLQKI VVTLCAFSIS FFLGILAYDS LMVIFFCPPN QCIRHAVCLY
LDSMAIFLTL LLMLSGPRWI SLSDGAPLDN GTLTAASTTG KS
