ID   US20_HCMVT              Reviewed;         342 AA.
AC   Q03307;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   23-FEB-2022, entry version 61.
DE   RecName: Full=Transmembrane protein HWLF3;
GN   Name=US20;
OS   Human cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10363;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8383226; DOI=10.1128/jvi.67.4.2043-2054.1993;
RA   Guo Y.-W., Huang E.S.;
RT   "Characterization of a structurally tricistronic gene of human
RT   cytomegalovirus composed of U(s)18, U(s)19, and U(s)20.";
RL   J. Virol. 67:2043-2054(1993).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: Expressed 18 hours post-infection. A second
CC       initiation codon (Met-89) is probably used at 34 hours post-infection.
CC   -!- SIMILARITY: Belongs to the cytomegalovirus US12 family. {ECO:0000305}.
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DR   EMBL; L04998; AAA45989.1; -; Genomic_DNA.
DR   PIR; A45678; A45678.
DR   SMR; Q03307; -.
DR   TCDB; 1.A.14.4.1; the calcium transporter a (cata) (formerly the testis-enhanced gene transfer (tegt) family.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR006214; Bax_inhibitor_1-related.
DR   Pfam; PF01027; Bax1-I; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Late protein; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..342
FT                   /note="Transmembrane protein HWLF3"
FT                   /id="PRO_0000115282"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        231..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        266..286
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        296..316
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          21..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        45..64
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        149
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        176
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        330
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   342 AA;  38210 MW;  22EDA6EC9B4535E0 CRC64;
     MRVISRARSA CTWTSCTSLS PCSTSCPPSP AAPTLLRRRS LPQQRRRPSS SPNRRVRGVT
     TSPCPTRSLV YKRRVGAPQR LCAETVATMQ AQEANALLLS RMEALEWFKK FTVWLRVYAI
     FIFQLAFSFG LGSVFWLGFP QNRNFCVENY SFFLTVLVPI VCMFITYTLG NEHPSNATVL
     FIYLLANSLT AAIFQMCSES RVLVGSYVMT LALFISFTGL AFLGGRDRRR WKCISCVYVV
     MLLSFLTLAL LSDADWLQKI VVTLCAFSIS FFLGILAYDS LMVIFFCPPN QCIRHAVCLY
     LDSMAIFLTL LLMLSGPRWI SLSDGVPLDN GTLTAASTTG KS