ID   US21_HCMVM              Reviewed;         243 AA.
AC   F5HHT6;
DT   11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   02-JUN-2021, entry version 25.
DE   RecName: Full=Membrane protein US21;
GN   Name=US21;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cytomegalovirus US12 family. {ECO:0000305}.
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DR   EMBL; AY446894; AAR31710.1; -; Genomic_DNA.
DR   RefSeq; YP_081606.1; NC_006273.2.
DR   TCDB; 1.A.14.3.12; the calcium transporter a (cata) (formerly the testis-enhanced gene transfer (tegt) family.
DR   PRIDE; F5HHT6; -.
DR   GeneID; 3077437; -.
DR   KEGG; vg:3077437; -.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR006214; Bax_inhibitor_1-related.
DR   PANTHER; PTHR23291; PTHR23291; 1.
DR   Pfam; PF01027; Bax1-I; 1.
PE   3: Inferred from homology;
KW   Host membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..243
FT                   /note="Membrane protein US21"
FT                   /id="PRO_0000418323"
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        80..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   243 AA;  26927 MW;  756CF7CE0E2B7334 CRC64;
     MSLRGQVQIA RSVFLLRIYI LIWVQCLILM SVCAFCWLVL PHRLEQLFSS VRLTLSCLMI
     SIVCLGLLRW AEPNFPKNVW ILLTYTLLTS VAVTASGFHF SHRSVIYAMV ATVTLFCFLT
     LATYLFARDV ELQRSLLTGA STLILLLFAV FSLFPEAVSE ILVMIAGLAV IVTSVVCDTQ
     DILHDIEYES YIPGALCLYM DLMYLFVSVL YFMPSEPGSA HTAQTTVAAT VAATAAASPQ
     FVS