ID   US22_HCMVA              Reviewed;         576 AA.
AC   P09722; Q7M6F5;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 2.
DT   02-JUN-2021, entry version 68.
DE   RecName: Full=Early nuclear protein HWLF1;
DE   AltName: Full=Tegument protein US22;
GN   Name=US22;
OS   Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10360;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3031311; DOI=10.1016/0022-2836(86)90359-1;
RA   Weston K.M., Barrell B.G.;
RT   "Sequence of the short unique region, short repeats, and part of the long
RT   repeats of human cytomegalovirus.";
RL   J. Mol. Biol. 192:177-208(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2161319; DOI=10.1007/978-3-642-74980-3_6;
RA   Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA   Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA   Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT   "Analysis of the protein-coding content of the sequence of human
RT   cytomegalovirus strain AD169.";
RL   Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN   [3]
RP   SUBCELLULAR LOCATION.
RX   PubMed=12029146; DOI=10.1099/0022-1317-83-6-1315;
RA   Adair R., Douglas E.R., Maclean J.B., Graham S.Y., Aitken J.D.,
RA   Jamieson F.E., Dargan D.J.;
RT   "The products of human cytomegalovirus genes UL23, UL24, UL43 and US22 are
RT   tegument components.";
RL   J. Gen. Virol. 83:1315-1324(2002).
RN   [4]
RP   GENOME REANNOTATION, AND SEQUENCE REVISION TO N-TERMINUS.
RX   PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RT   "The human cytomegalovirus genome revisited: comparison with the chimpanzee
RT   cytomegalovirus genome.";
RL   J. Gen. Virol. 84:17-28(2003).
RN   [5]
RP   ERRATUM OF PUBMED:12533697.
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RL   J. Gen. Virol. 84:1053-1053(2003).
RN   [6]
RP   IDENTIFICATION.
RX   PubMed=15452216; DOI=10.1128/jvi.78.20.10960-10966.2004;
RA   Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J.,
RA   Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W.,
RA   Shenk T., Smith R.D., Nelson J.A.;
RT   "Identification of proteins in human cytomegalovirus (HCMV) particles: the
RT   HCMV proteome.";
RL   J. Virol. 78:10960-10966(2004).
RN   [7]
RP   ERRATUM OF PUBMED:15452216.
RA   Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J.,
RA   Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W.,
RA   Shenk T., Smith R.D., Nelson J.A.;
RL   J. Virol. 78:13395-13395(2004).
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000269|PubMed:12029146}.
CC   -!- SIMILARITY: Belongs to the herpesviridae US22 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA35289.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=CAB37114.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; X17403; CAA35289.1; ALT_INIT; Genomic_DNA.
DR   EMBL; X04650; CAB37114.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BK000394; DAA00238.1; -; Genomic_DNA.
DR   PIR; F27231; QQBEG6.
DR   Proteomes; UP000008991; Genome.
DR   Proteomes; UP000008992; Genome.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   InterPro; IPR003360; US22-like.
DR   Pfam; PF02393; US22; 2.
PE   3: Inferred from homology;
KW   Reference proteome; Virion; Virion tegument.
FT   CHAIN           1..576
FT                   /note="Early nuclear protein HWLF1"
FT                   /id="PRO_0000115284"
FT   REGION          471..576
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        477..491
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        495..511
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   576 AA;  65031 MW;  B33EA9A510DE2494 CRC64;
     MSLLTKAAAE AWGTYLRQRD ERCEDAIRCD YGVFQFRNTV FQKTLSMLQG LYLRQYDPPA
     LRTYVQRHQG TTVALRNPAN WFLVMREQAA IPQIYARSLA ADYLCCDDTL EAVGVLAVRP
     PDSDLTRNTK QAQELPCVLM LSHYGTVYVY DWETDGLYEV ASDIKAFSKN GLLWCEYVYR
     HPQTPFATTE PRYHVQKFLC TDPTDAAAVA KTAREMSGLN LVIRTPGRTE VEPLLMLGSI
     EGLRACRPFD HMPAADFRDL LNFIRQRLCC EWYVVGLVGY YLAYGPFVPS GLVLLDKFGV
     VYLHKIEDSD LYRIADNFHM FLKCGLLKLR GLCRFDRGLR GECRLEELPV CHHTLKRDVL
     RWHGALGTIT RSQLESALDW FLRPTRGTDK VPNNSSAWGR TDLLPTGALQ DNQNWAFPSH
     SVETLPALQG GLWEDNDETT QTVDGQRCFR MPKFFPPPMC RVPYNECGVE LPGGDSSDED
     ESGRPRRIAN RIGDTPETPC NSENEDDTTV EGTSGGPEAM DSQAPYPSED SPTTEKEAWL
     QRGRRAKAMH ARGHTLKQVP IPEPDQMGDD GPDPGP