ID   US22_HCMVM              Reviewed;         576 AA.
AC   F5HDC7;
DT   11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   23-FEB-2022, entry version 22.
DE   RecName: Full=Tegument protein US22;
GN   Name=US22;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the herpesviridae US22 family. {ECO:0000305}.
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DR   EMBL; AY446894; AAR31711.1; -; Genomic_DNA.
DR   RefSeq; YP_081607.1; NC_006273.2.
DR   PRIDE; F5HDC7; -.
DR   GeneID; 3077463; -.
DR   KEGG; vg:3077463; -.
DR   Reactome; R-HSA-9609690; HCMV Early Events.
DR   Reactome; R-HSA-9610379; HCMV Late Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0019033; C:viral tegument; TAS:Reactome.
DR   InterPro; IPR003360; US22-like.
DR   Pfam; PF02393; US22; 2.
PE   3: Inferred from homology;
KW   Reference proteome; Virion; Virion tegument.
FT   CHAIN           1..576
FT                   /note="Tegument protein US22"
FT                   /id="PRO_0000418295"
FT   REGION          471..576
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        477..491
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        495..511
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   576 AA;  65048 MW;  18C43B2E3A8143B0 CRC64;
     MSLLTKAAAE AWGTYLRQRD ERCEDAIRCD YGVFQFRNTV FQKTLSMLQG LYLRQYDPPA
     LRTYVQRHQG TTVALRNPAN WFLVMREQAA IPQIYARSLA ADYLCCDDTL EAVGVLAVRP
     PDSDLTRNTK QAQELPCVLM LSHYGTVYVY DWETDGLYEV ASDIKAFSKN GLLWCEYVYR
     HPQTPFATTE PRYHVQKFLC TDPTDAAAVA KTAREMNGLN LVIRTPGRTE VEPLLMLGSI
     EGLRACRPFD HMPAADFRDL LNFIRQRLCC EWYVVGLVGY YLAYGPFVPS GMVLLDKFGV
     VYLHKIEDSD LYRIADNFHM FLKCGLLKLR GLCRFDRGLR GECRLEELPV CHHTLKRDVL
     RWHGALGTIT RSQLESALDW FLRPTRGTDK VPNNSSAWGR TDLLPTGALQ DNQNWAFPSH
     SVETLPALQG GLWEDNDETT QTVDGQRCFR MPKFFPPPMC RAPYNECGVE LPGGDSSDED
     ESGRPRRIAN RIGDTPETPC NSENEDDTTV EGTSGGPEAM DSQAPYPSED SPTTEKEAWL
     QRGRRAKAMH ARGHTLKQVP IPEPDQMGDD GPDPGP