ID   US23_HCMVA              Reviewed;         592 AA.
AC   P09701; Q7M6H7;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 2.
DT   02-JUN-2021, entry version 68.
DE   RecName: Full=Tegument protein US23;
DE   AltName: Full=Protein HHLF7;
GN   Name=US23;
OS   Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10360;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3031311; DOI=10.1016/0022-2836(86)90359-1;
RA   Weston K.M., Barrell B.G.;
RT   "Sequence of the short unique region, short repeats, and part of the long
RT   repeats of human cytomegalovirus.";
RL   J. Mol. Biol. 192:177-208(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2161319; DOI=10.1007/978-3-642-74980-3_6;
RA   Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA   Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA   Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT   "Analysis of the protein-coding content of the sequence of human
RT   cytomegalovirus strain AD169.";
RL   Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN   [3]
RP   GENOME REANNOTATION.
RX   PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RT   "The human cytomegalovirus genome revisited: comparison with the chimpanzee
RT   cytomegalovirus genome.";
RL   J. Gen. Virol. 84:17-28(2003).
RN   [4]
RP   ERRATUM OF PUBMED:12533697.
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RL   J. Gen. Virol. 84:1053-1053(2003).
RN   [5]
RP   IDENTIFICATION.
RX   PubMed=15452216; DOI=10.1128/jvi.78.20.10960-10966.2004;
RA   Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J.,
RA   Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W.,
RA   Shenk T., Smith R.D., Nelson J.A.;
RT   "Identification of proteins in human cytomegalovirus (HCMV) particles: the
RT   HCMV proteome.";
RL   J. Virol. 78:10960-10966(2004).
RN   [6]
RP   ERRATUM OF PUBMED:15452216.
RA   Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J.,
RA   Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W.,
RA   Shenk T., Smith R.D., Nelson J.A.;
RL   J. Virol. 78:13395-13395(2004).
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the herpesviridae US22 family. {ECO:0000305}.
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DR   EMBL; X17403; CAA35290.1; -; Genomic_DNA.
DR   EMBL; X04650; CAB37115.1; -; Genomic_DNA.
DR   EMBL; BK000394; DAA00211.1; -; Genomic_DNA.
DR   PIR; G27231; QQBEG7.
DR   PRIDE; P09701; -.
DR   Proteomes; UP000008991; Genome.
DR   Proteomes; UP000008992; Genome.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   InterPro; IPR003360; US22-like.
DR   Pfam; PF02393; US22; 2.
PE   3: Inferred from homology;
KW   Reference proteome; Virion; Virion tegument.
FT   CHAIN           1..592
FT                   /note="Tegument protein US23"
FT                   /id="PRO_0000115285"
FT   REGION          407..491
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        432..447
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        460..477
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   592 AA;  68884 MW;  3BCEBB86104AC1DE CRC64;
     MWRTRWEDGA PTFTRNDEFL YCHTRYETFL RVMGDFQGIF ECQYSADVLR DWVRNHVDQV
     LSLGIPHNWF LQVRPGSTMP ELRDQLLDDV ICCPERLIVL GKCVIMVEDH YEETELVLCM
     GGGTRLYIYE PSQEILLLCA RHLDELARYG MMYTEAVYRQ PQTPFATRVP HDVVAMLLRH
     GHDADALAAC VGEHHGRDVN FHTPGRHAKT LKLLTSFGCL TDCWPFEVAP AARLAECEMY
     VTLQLRCRWY LLGAVGSYRA GGFFDTSFLI IFDRFCRFYV VIVKSHLDRS PPLQRLAGEI
     YRLADSLEEL FRAGLMKVYV RRRYEHGLRR AARLERNGGC VHMGEAARLH FTMFDSGVDR
     DYARQFRWLC RGDRFRAEML NNWDGWDAFT IWQARVVRGD FAERRRPRSL GDGEEEDEGN
     DGRAMPVVRR RPPPMPRDDD EDNHVVPDNQ NLEVIHDALA DDEEQGEDDD DSGAEPMEPE
     ENNVVPNVER RGGEDAVAAR MAAGHESDDD EWEDLGFDLE EDTVFDLKDV DEWFEQRRLA
     EKERWHLGQR IVNAYRTEAE VSEAEVEARR INLNTDLSPE WVKSFDFREH FV