ID   US23_HCMVM              Reviewed;         592 AA.
AC   F5HAZ3;
DT   18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   23-FEB-2022, entry version 22.
DE   RecName: Full=Protein US23;
GN   Name=US23;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the herpesviridae US22 family. {ECO:0000305}.
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DR   EMBL; AY446894; AAR31712.1; -; Genomic_DNA.
DR   RefSeq; YP_081608.1; NC_006273.2.
DR   PRIDE; F5HAZ3; -.
DR   GeneID; 3077446; -.
DR   KEGG; vg:3077446; -.
DR   Reactome; R-HSA-9609690; HCMV Early Events.
DR   Reactome; R-HSA-9610379; HCMV Late Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0019033; C:viral tegument; TAS:Reactome.
DR   InterPro; IPR003360; US22-like.
DR   Pfam; PF02393; US22; 2.
PE   3: Inferred from homology;
KW   Reference proteome; Virion; Virion tegument.
FT   CHAIN           1..592
FT                   /note="Protein US23"
FT                   /id="PRO_0000416728"
FT   REGION          407..491
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        432..447
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        460..477
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   592 AA;  68886 MW;  BF48A1B9E11DDEB6 CRC64;
     MWRTRWEDGA PTFTRNDEFL YCHTRYETFL RVMGDFQGIF ECQYSADVLR DWVRNHVDQV
     LSLGIPHNWF LQVRPGSTMP ELRDQLLDDV ICCPERLIVL GKCVIMVDDH YEETELVLCM
     GGGTRLYIYE PSQEILLLCA RHLDELARYG MMYTEAVYRQ PQTPFATRVP HDVVAMLLRH
     GHDTDALAAC VGEHHGRDVN FHTPGRHAKT LKLLTSFGCL TDCWPFEVAP AARLAECEMY
     VTLQLRCRWY LLGAVGSYRA GGFFDTSFLI IFDRFCRFYV VIVKSHLDRS PPLQRLAGEI
     YRLADSLEEL FRAGLMKVYV RRRYEHGLRR AARLERNGGC VHMGEAARLH FTMFDSGVDR
     DYARQFRWLC RGDRFRAEML NNWDGWDAFT IWQARVVRGD FAERRRPRSL GDGEEEDEGN
     DGRAMPVVRR RPPPMPRDDD EDNHVVPDNQ NLEVIHDALA DDEEQGEDDD DSGAEPMEPE
     ENNVVPNVDR RGGEDAVAAR MAAGHESDDD EWEDLGFDLE EDTVFDLKDV DEWFEQRRLA
     EKERWHLGQR IVNAYRTEAE VSEAEVEARR INLNTDLSPE WVKSFDFREH FV