ID   US29_HCMVA              Reviewed;         462 AA.
AC   P09705; Q7M6H2;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   02-JUN-2021, entry version 55.
DE   RecName: Full=Uncharacterized protein HHRF4;
GN   Name=US29;
OS   Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10360;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3031311; DOI=10.1016/0022-2836(86)90359-1;
RA   Weston K.M., Barrell B.G.;
RT   "Sequence of the short unique region, short repeats, and part of the long
RT   repeats of human cytomegalovirus.";
RL   J. Mol. Biol. 192:177-208(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2161319; DOI=10.1007/978-3-642-74980-3_6;
RA   Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA   Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA   Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT   "Analysis of the protein-coding content of the sequence of human
RT   cytomegalovirus strain AD169.";
RL   Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN   [3]
RP   GENOME REANNOTATION.
RX   PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RT   "The human cytomegalovirus genome revisited: comparison with the chimpanzee
RT   cytomegalovirus genome.";
RL   J. Gen. Virol. 84:17-28(2003).
RN   [4]
RP   ERRATUM OF PUBMED:12533697.
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RL   J. Gen. Virol. 84:1053-1053(2003).
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the HHV-5 US29 protein family. {ECO:0000305}.
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DR   EMBL; X17403; CAA35261.1; -; Genomic_DNA.
DR   EMBL; X04650; CAA28339.1; -; Genomic_DNA.
DR   EMBL; BK000394; DAA00216.1; -; Genomic_DNA.
DR   PIR; D27216; QQBED4.
DR   PRIDE; P09705; -.
DR   Proteomes; UP000008991; Genome.
DR   Proteomes; UP000008992; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Host membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..462
FT                   /note="Uncharacterized protein HHRF4"
FT                   /id="PRO_0000115289"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        257..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   462 AA;  51067 MW;  D8D070B42EB6B289 CRC64;
     MRCFRWWLYS GWWWLTFGCA RTVTVGFVAP TVRAQSTVVR SEPAPPSETR RDNNDTSYFS
     STSFHSSVSP ATSVDRQFRR TTYDRWDGRR WLRTRYGNAS ACVTGTQWST NFFFSQCEHY
     PSFVKLNGVQ RWTPVRRPMG EVAYYGGCCM VGGGNRAYVI LVSGYGTASY GNALRVNFGR
     GNCTAPKRTY PRRLELHDGR TDPSRCDPYQ VYFYGLQCPE QLVITAHGGV GMRRCPTGSR
     PTPSRPHRHD LENELHGLCV DLLVCVLLLA LLLLELVPME AVRHPLLFWR RVALSPSTSK
     VDRAVKLCLR RMFGLPPPPS VAPPGEKKEL PAQAALSPPL TTWSLPPFPS TRIPDSPPPP
     YQLRHATSLV TVPTLLLYTS SDIGDTASET TCVAHATYGE PPEPARSTAT VQECTVLTAP
     NCGIVNNDGA VSEGQDHGDA VHHSLDVVSQ CAADTGVVDT SE