US74C_DROME
ID US74C_DROME Reviewed; 373 AA.
AC Q95YI5; Q9VVG8;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2002, sequence version 2.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=UDP-sugar transporter UST74c;
DE AltName: Full=Protein fringe connection;
GN Name=frc; Synonyms=UST74C; ORFNames=CG3874;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11533661; DOI=10.1038/ncb0901-816;
RA Goto S., Taniguchi M., Muraoka M., Toyoda H., Sado Y., Kawakita M.,
RA Hayashi S.;
RT "UDP-sugar transporter implicated in glycosylation and processing of
RT Notch.";
RL Nat. Cell Biol. 3:816-822(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- FUNCTION: Involved in the import of UDP-sugars from the cytoplasm into
CC the Golgi lumen.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass membrane
CC protein.
CC -!- SIMILARITY: Belongs to the TPT transporter family. SLC35D subfamily.
CC {ECO:0000305}.
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DR EMBL; AB062677; BAB62105.1; -; mRNA.
DR EMBL; AE014296; AAF49343.1; -; Genomic_DNA.
DR EMBL; AY129459; AAM76201.1; -; mRNA.
DR RefSeq; NP_001137962.1; NM_001144490.3.
DR RefSeq; NP_524126.1; NM_079402.4.
DR AlphaFoldDB; Q95YI5; -.
DR SMR; Q95YI5; -.
DR BioGRID; 65232; 3.
DR DIP; DIP-23605N; -.
DR IntAct; Q95YI5; 2.
DR STRING; 7227.FBpp0289098; -.
DR TCDB; 2.A.7.15.3; the drug/metabolite transporter (dmt) superfamily.
DR iPTMnet; Q95YI5; -.
DR PaxDb; Q95YI5; -.
DR PRIDE; Q95YI5; -.
DR DNASU; 39943; -.
DR EnsemblMetazoa; FBtr0075228; FBpp0074990; FBgn0042641.
DR EnsemblMetazoa; FBtr0299820; FBpp0289098; FBgn0042641.
DR GeneID; 39943; -.
DR KEGG; dme:Dmel_CG3874; -.
DR CTD; 39943; -.
DR FlyBase; FBgn0042641; frc.
DR VEuPathDB; VectorBase:FBgn0042641; -.
DR eggNOG; KOG1444; Eukaryota.
DR GeneTree; ENSGT00940000167969; -.
DR HOGENOM; CLU_040726_1_1_1; -.
DR InParanoid; Q95YI5; -.
DR OMA; IQSTVCV; -.
DR PhylomeDB; Q95YI5; -.
DR Reactome; R-DME-173599; Formation of the active cofactor, UDP-glucuronate.
DR Reactome; R-DME-2022854; Keratan sulfate biosynthesis.
DR Reactome; R-DME-2022928; HS-GAG biosynthesis.
DR Reactome; R-DME-727802; Transport of nucleotide sugars.
DR SignaLink; Q95YI5; -.
DR BioGRID-ORCS; 39943; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 39943; -.
DR PRO; PR:Q95YI5; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0042641; Expressed in Malpighian tubule and 12 other tissues.
DR Genevisible; Q95YI5; DM.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0005797; C:Golgi medial cisterna; IDA:FlyBase.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IDA:FlyBase.
DR GO; GO:0005459; F:UDP-galactose transmembrane transporter activity; IDA:FlyBase.
DR GO; GO:0005460; F:UDP-glucose transmembrane transporter activity; IDA:FlyBase.
DR GO; GO:0005461; F:UDP-glucuronic acid transmembrane transporter activity; IDA:FlyBase.
DR GO; GO:0005463; F:UDP-N-acetylgalactosamine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005462; F:UDP-N-acetylglucosamine transmembrane transporter activity; IDA:FlyBase.
DR GO; GO:0005464; F:UDP-xylose transmembrane transporter activity; IDA:FlyBase.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0001745; P:compound eye morphogenesis; IMP:FlyBase.
DR GO; GO:0009880; P:embryonic pattern specification; IMP:FlyBase.
DR GO; GO:0007447; P:imaginal disc pattern formation; IMP:FlyBase.
DR GO; GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase.
DR GO; GO:0007367; P:segment polarity determination; IMP:FlyBase.
DR GO; GO:0007423; P:sensory organ development; IMP:FlyBase.
DR GO; GO:0072334; P:UDP-galactose transmembrane transport; IDA:FlyBase.
DR GO; GO:0015786; P:UDP-glucose transmembrane transport; IDA:FlyBase.
DR GO; GO:0015787; P:UDP-glucuronic acid transmembrane transport; IDA:FlyBase.
DR GO; GO:1990569; P:UDP-N-acetylglucosamine transmembrane transport; IDA:FlyBase.
DR GO; GO:0015790; P:UDP-xylose transmembrane transport; IDA:FlyBase.
DR InterPro; IPR004853; Sugar_P_trans_dom.
DR Pfam; PF03151; TPT; 1.
PE 1: Evidence at protein level;
KW Golgi apparatus; Membrane; Phosphoprotein; Reference proteome;
KW Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..373
FT /note="UDP-sugar transporter UST74c"
FT /id="PRO_0000213396"
FT TRANSMEM 89..111
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..153
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..196
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..225
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..297
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 302..324
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 329..351
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 27..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 50
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT CONFLICT 269
FT /note="E -> G (in Ref. 1; BAB62105)"
FT /evidence="ECO:0000305"
FT CONFLICT 275
FT /note="V -> L (in Ref. 1; BAB62105)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 373 AA; 41182 MW; 53DDFF6DA6A76AA5 CRC64;
MSMSRGGNTT LDLQPLLAES DVGNRELEEK MGGSADRSSL LDGSGSKELS HREREDSALF
VKKIGSALFY GLSSFMITVV NKTVLTSYHF PSFLFLSLGQ LTASIVVLGM GKRLKLVNFP
PLQRNTFAKI FPLPLIFLGN MMFGLGGTKT LSLPMFAALR RFSILMTMLL ELKILGLRPS
NAVQVSVYAM IGGALLAASD DLSFNMRGYI YVMITNALTA SNGVYVKKKL DTSEIGKYGL
MYYNSLFMFL PALALNYVTG NLDQALNFEQ WNDSVFVVQF LLSCVMGFIL SYSTILCTQF
NSALTTTIVG CLKNICVTYL GMFIGGDYVF SWLNCIGINI SVLASLLYTY VTFRRKRAPD
KQDHLPSTRG ENV
