ID   US9_CHV1                Reviewed;          90 AA.
AC   P30025;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   02-JUN-2021, entry version 72.
DE   RecName: Full=Envelope protein US9 homolog;
DE   AltName: Full=10 kDa protein;
OS   Cercopithecine herpesvirus 1 (CeHV-1) (Simian herpes B virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10325;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9541; Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OH   NCBI_TaxID=90387; Macaca leonina (Northern pig-tailed macaque) (Macaca nemestrina leonina).
OH   NCBI_TaxID=9544; Macaca mulatta (Rhesus macaque).
OH   NCBI_TaxID=9545; Macaca nemestrina (Pig-tailed macaque).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1309859; DOI=10.1099/0022-1317-73-1-195;
RA   Killeen A.M., Harrington L., Wall L.V.M., Kelly D.C.;
RT   "Nucleotide sequence analysis of a homologue of herpes simplex virus type 1
RT   gene US9 found in the genome of simian herpes B virus.";
RL   J. Gen. Virol. 73:195-199(1992).
CC   -!- FUNCTION: Essential for the anterograde spread of the infection
CC       throughout the host nervous system. Together with the gE/gI
CC       heterodimer, US9 is involved in the sorting and transport of viral
CC       structural components toward axon tips (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250}; Single-pass type
CC       II membrane protein {ECO:0000250}. Host Golgi apparatus membrane
CC       {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Host
CC       smooth endoplasmic reticulum membrane {ECO:0000250}; Single-pass type
CC       II membrane protein {ECO:0000250}. Host cell membrane {ECO:0000305};
CC       Single-pass type II membrane protein {ECO:0000305}. Note=During virion
CC       morphogenesis, this protein probably accumulates in the endosomes and
CC       trans-Golgi where secondary envelopment occurs. It is probably
CC       transported to the cell surface from where it is endocytosed and
CC       directed to the trans-Golgi network (TGN), maybe through an interaction
CC       with PACS-1 sorting protein.
CC   -!- PTM: Phosphorylated on serines within the acidic cluster.
CC       Phosphorylation determines whether endocytosed viral US9 traffics to
CC       the trans-Golgi network or recycles to the cell membrane.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the alphaherpesvirinae envelope protein US9
CC       family. {ECO:0000305}.
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DR   EMBL; S75996; AAB21002.1; -; Genomic_DNA.
DR   PIR; JQ1406; QQBECE.
DR   GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044171; C:host cell smooth endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0075733; P:intracellular transport of virus; IEA:InterPro.
DR   InterPro; IPR009278; Herpes_US9.
DR   Pfam; PF06072; Herpes_US9; 1.
PE   3: Inferred from homology;
KW   Host cell membrane; Host endoplasmic reticulum; Host Golgi apparatus;
KW   Host membrane; Membrane; Signal-anchor; Transmembrane; Transmembrane helix;
KW   Viral envelope protein; Virion.
FT   CHAIN           1..90
FT                   /note="Envelope protein US9 homolog"
FT                   /id="PRO_0000116139"
FT   TOPO_DOM        1..63
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        64..84
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        85..90
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000250"
FT   REGION          29..38
FT                   /note="Acidic"
FT   MOTIF           12..13
FT                   /note="Di-leucine internalization motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   90 AA;  9930 MW;  93E203F63D389E4D CRC64;
     MEPLRLADAE SLLSETSVIP LTPPAQTPEA YYTESDDETA ADFLVRMGRQ QTAIRRRRRQ
     TRAAGFVAAF VLVALISGGL GALMCWLAYR