ID   US9_EHV1A               Reviewed;          76 AA.
AC   P18554;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   29-SEP-2021, entry version 54.
DE   RecName: Full=Envelope protein US9 homolog;
DE   AltName: Full=Envelope protein 76;
DE   AltName: Full=ORF76 protein;
DE   Flags: Fragment;
GN   OrderedLocusNames=76;
OS   Equine herpesvirus 1 (strain AB1) (EHV-1) (Equine abortion virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=10328;
OH   NCBI_TaxID=9796; Equus caballus (Horse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1647359; DOI=10.1016/0378-1119(91)90412-5;
RA   Elton D.M., Halliburton I.W., Killington R.A., Meredith D.M., Bonass W.A.;
RT   "Sequence analysis of the 4.7-kb BamHI-EcoRI fragment of the equine
RT   herpesvirus type-1 short unique region.";
RL   Gene 101:203-208(1991).
CC   -!- FUNCTION: Essential for the anterograde spread of the infection
CC       throughout the host nervous system. Together with the gE/gI
CC       heterodimer, US9 is involved in the sorting and transport of viral
CC       structural components toward axon tips (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250}; Single-pass type
CC       II membrane protein {ECO:0000250}. Host Golgi apparatus membrane
CC       {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Host
CC       smooth endoplasmic reticulum membrane {ECO:0000250}; Single-pass type
CC       II membrane protein {ECO:0000250}. Host cell membrane {ECO:0000305};
CC       Single-pass type II membrane protein {ECO:0000305}. Note=During virion
CC       morphogenesis, this protein probably accumulates in the endosomes and
CC       trans-Golgi where secondary envelopment occurs. It is probably
CC       transported to the cell surface from where it is endocytosed and
CC       directed to the trans-Golgi network (TGN), maybe through an interaction
CC       with PACS-1 sorting protein.
CC   -!- SIMILARITY: Belongs to the alphaherpesvirinae envelope protein US9
CC       family. {ECO:0000305}.
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DR   EMBL; M36299; AAA66550.1; -; Genomic_DNA.
DR   GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044171; C:host cell smooth endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Host cell membrane; Host endoplasmic reticulum; Host Golgi apparatus;
KW   Host membrane; Membrane; Viral envelope protein; Virion.
FT   CHAIN           1..>76
FT                   /note="Envelope protein US9 homolog"
FT                   /id="PRO_0000116133"
FT   NON_TER         76
SQ   SEQUENCE   76 AA;  7633 MW;  27ADE2FD2D4F0928 CRC64;
     MEKAEAAAVV IPLSVSNPSY RGSGMSDQEV SEEQSAGDAW VSAAMAAAEA VAAAATSTGI
     DNTNDYTYTA ASENGD