US9_VZVO
ID US9_VZVO Reviewed; 102 AA.
AC Q77NN6;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 1.
DT 12-AUG-2020, entry version 37.
DE RecName: Full=Envelope protein US9;
DE AltName: Full=Envelope protein 65;
DE AltName: Full=ORF65 protein;
GN ORFNames=ORF65;
OS Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX NCBI_TaxID=341980;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=V-Oka(Biken);
RX PubMed=10720545; DOI=10.1086/315335;
RA Argaw T., Cohen J.I., Klutch M., Lekstrom K., Yoshikawa T., Asano Y.,
RA Krause P.R.;
RT "Nucleotide sequences that distinguish Oka vaccine from parental Oka and
RT other varicella-zoster virus isolates.";
RL J. Infect. Dis. 181:1153-1157(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Oka varicella vaccine Biken (V-Oka-Biken);
RX PubMed=11162813; DOI=10.1006/viro.2000.0775;
RA Faga B., Maury W., Bruckner D.A., Grose C.;
RT "Identification and mapping of single nucleotide polymorphisms in the
RT varicella-zoster virus genome.";
RL Virology 280:1-6(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate Human/Japan/P-Oka/1970, and
RC Oka varicella vaccine Biken (V-Oka-Biken);
RX PubMed=12388706; DOI=10.1128/jvi.76.22.11447-11459.2002;
RA Gomi Y., Sunamachi H., Mori Y., Nagaike K., Takahashi M., Yamanishi K.;
RT "Comparison of the complete DNA sequences of the Oka varicella vaccine and
RT its parental virus.";
RL J. Virol. 76:11447-11459(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Oka varicella vaccine VarilRix (V-Oka-GSK), and
RC Oka varicella vaccine Varivax (V-Oka-Merk);
RX PubMed=18787000; DOI=10.1128/jvi.00777-08;
RA Tillieux S.L., Halsey W.S., Thomas E.S., Voycik J.J., Sathe G.M.,
RA Vassilev V.;
RT "Complete DNA sequences of two oka strain varicella-zoster virus genomes.";
RL J. Virol. 82:11023-11044(2008).
CC -!- FUNCTION: Essential for the anterograde spread of the infection
CC throughout the host nervous system. Together with the gE/gI
CC heterodimer, US9 is involved in the sorting and transport of viral
CC structural components toward axon tips (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250}; Single-pass type
CC II membrane protein {ECO:0000250}. Host Golgi apparatus membrane
CC {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Host
CC smooth endoplasmic reticulum membrane {ECO:0000250}; Single-pass type
CC II membrane protein {ECO:0000250}. Host cell membrane {ECO:0000305};
CC Single-pass type II membrane protein {ECO:0000305}. Note=During virion
CC morphogenesis, this protein probably accumulates in the endosomes and
CC trans-Golgi where secondary envelopment occurs. It is probably
CC transported to the cell surface from where it is endocytosed and
CC directed to the trans-Golgi network (TGN), maybe through an interaction
CC with PACS-1 sorting protein.
CC -!- PTM: Phosphorylated on serines within the acidic cluster, possibly by
CC host CK2. Phosphorylation determines whether endocytosed viral US9
CC traffics to the trans-Golgi network or recycles to the cell membrane.
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the alphaherpesvirinae envelope protein US9
CC family. {ECO:0000305}.
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DR EMBL; AF206304; AAF61666.1; -; Genomic_DNA.
DR EMBL; AY016450; AAK19943.1; -; Genomic_DNA.
DR EMBL; AB097932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AB097933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DQ008354; AAY57674.1; -; Genomic_DNA.
DR EMBL; DQ008355; AAY57745.1; -; Genomic_DNA.
DR RefSeq; NP_040187.1; NC_001348.1.
DR IntAct; Q77NN6; 15.
DR GeneID; 1487702; -.
DR KEGG; vg:1487702; -.
DR Proteomes; UP000002603; Genome.
DR Proteomes; UP000008504; Genome.
DR Proteomes; UP000008505; Genome.
DR Proteomes; UP000008506; Genome.
DR GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044171; C:host cell smooth endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0075733; P:intracellular transport of virus; IEA:InterPro.
DR InterPro; IPR009278; Herpes_US9.
DR Pfam; PF06072; Herpes_US9; 1.
PE 3: Inferred from homology;
KW Host cell membrane; Host endoplasmic reticulum; Host Golgi apparatus;
KW Host membrane; Membrane; Phosphoprotein; Signal-anchor; Transmembrane;
KW Transmembrane helix; Viral envelope protein; Virion.
FT CHAIN 1..102
FT /note="Envelope protein US9"
FT /id="PRO_0000385485"
FT TOPO_DOM 1..75
FT /note="Intravirion"
FT /evidence="ECO:0000250"
FT TRANSMEM 76..96
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000250"
FT TOPO_DOM 97..102
FT /note="Virion surface"
FT /evidence="ECO:0000250"
FT REGION 41..55
FT /note="Acidic"
FT MOTIF 14..15
FT /note="Di-leucine internalization motif"
FT /evidence="ECO:0000255"
FT MOD_RES 46
FT /note="Phosphoserine; by host CK2"
FT /evidence="ECO:0000255"
FT MOD_RES 48
FT /note="Phosphoserine; by host CK2"
FT /evidence="ECO:0000255"
SQ SEQUENCE 102 AA; 11436 MW; 18801A669057A3A3 CRC64;
MAGQNTMEGE AVALLMEAVV TPRAQPNNTT ITAIQPSRSA EKCYYSDSEN ETADEFLRRI
GKYQHKIYHR KKFCYITLII VFVFAMTGAA FALGYITSQF VG
