USBP1_HUMAN
ID USBP1_HUMAN Reviewed; 703 AA.
AC Q8N6Y0; A8K7L6; B2RCR9; Q8NBX7; Q96KH3; Q9BYI8;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Harmonin-binding protein USHBP1 {ECO:0000305};
DE AltName: Full=AIE-75-binding protein;
DE AltName: Full=Mutated in colon cancer protein 2;
DE Short=MCC-2;
DE AltName: Full=Usher syndrome type-1C protein-binding protein 1;
DE Short=USH1C-binding protein 1;
GN Name=USHBP1 {ECO:0000312|EMBL:AAH27910.1};
GN Synonyms=AIEBP {ECO:0000312|EMBL:BAB41203.1}, MCC2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000305, ECO:0000312|EMBL:BAB41203.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), INTERACTION WITH USH1C,
RP TISSUE SPECIFICITY, AND VARIANT VAL-439.
RC TISSUE=Kidney {ECO:0000312|EMBL:BAB43978.1}, and
RC Placenta {ECO:0000312|EMBL:BAB41203.1};
RX PubMed=11311560; DOI=10.1016/s0378-1119(01)00378-x;
RA Ishikawa S., Kobayashi I., Hamada J., Tada M., Hirai A., Furuuchi K.,
RA Takahashi Y., Ba Y., Moriuchi T.;
RT "Interaction of MCC2, a novel homologue of MCC tumor suppressor, with PDZ-
RT domain protein AIE-75.";
RL Gene 267:101-110(2001).
RN [2] {ECO:0000305, ECO:0000312|EMBL:BAC11443.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta {ECO:0000312|EMBL:BAC11443.1}, and Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAH27910.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Interacts via its C-terminus with the first PDZ domain of
CC USH1C. {ECO:0000269|PubMed:11311560}.
CC -!- INTERACTION:
CC Q8N6Y0; Q8NFV4-4: ABHD11; NbExp=3; IntAct=EBI-739895, EBI-12318443;
CC Q8N6Y0; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-739895, EBI-11096309;
CC Q8N6Y0; Q8TDX5-2: ACMSD; NbExp=3; IntAct=EBI-739895, EBI-12809094;
CC Q8N6Y0; Q99996-2: AKAP9; NbExp=3; IntAct=EBI-739895, EBI-9641546;
CC Q8N6Y0; Q7Z3H0-1: ANKRD33; NbExp=3; IntAct=EBI-739895, EBI-16746154;
CC Q8N6Y0; Q96IX9: ANKRD36BP1; NbExp=3; IntAct=EBI-739895, EBI-744859;
CC Q8N6Y0; P53365: ARFIP2; NbExp=3; IntAct=EBI-739895, EBI-638194;
CC Q8N6Y0; Q96C12: ARMC5; NbExp=3; IntAct=EBI-739895, EBI-6425121;
CC Q8N6Y0; Q8WXK1: ASB15; NbExp=3; IntAct=EBI-739895, EBI-12809012;
CC Q8N6Y0; P48047: ATP5PO; NbExp=3; IntAct=EBI-739895, EBI-355815;
CC Q8N6Y0; O75934: BCAS2; NbExp=3; IntAct=EBI-739895, EBI-1050106;
CC Q8N6Y0; O43521: BCL2L11; NbExp=3; IntAct=EBI-739895, EBI-526406;
CC Q8N6Y0; O15155: BET1; NbExp=2; IntAct=EBI-739895, EBI-749204;
CC Q8N6Y0; Q9BXY8: BEX2; NbExp=3; IntAct=EBI-739895, EBI-745073;
CC Q8N6Y0; Q00994: BEX3; NbExp=6; IntAct=EBI-739895, EBI-741753;
CC Q8N6Y0; Q12934-2: BFSP1; NbExp=3; IntAct=EBI-739895, EBI-12123320;
CC Q8N6Y0; Q13515: BFSP2; NbExp=6; IntAct=EBI-739895, EBI-10229433;
CC Q8N6Y0; Q6AI39: BICRAL; NbExp=3; IntAct=EBI-739895, EBI-1012434;
CC Q8N6Y0; P78537: BLOC1S1; NbExp=3; IntAct=EBI-739895, EBI-348630;
CC Q8N6Y0; Q9H2G9: BLZF1; NbExp=3; IntAct=EBI-739895, EBI-2548012;
CC Q8N6Y0; Q96GS4: BORCS6; NbExp=3; IntAct=EBI-739895, EBI-10193358;
CC Q8N6Y0; Q6PJG6: BRAT1; NbExp=3; IntAct=EBI-739895, EBI-10826195;
CC Q8N6Y0; P55201-2: BRPF1; NbExp=3; IntAct=EBI-739895, EBI-12065306;
CC Q8N6Y0; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-739895, EBI-8643161;
CC Q8N6Y0; Q8TAB5: C1orf216; NbExp=7; IntAct=EBI-739895, EBI-747505;
CC Q8N6Y0; Q0VAL7: C21orf58; NbExp=3; IntAct=EBI-739895, EBI-10226774;
CC Q8N6Y0; Q8NA61-2: CBY2; NbExp=3; IntAct=EBI-739895, EBI-11524851;
CC Q8N6Y0; Q8IW40: CCDC103; NbExp=3; IntAct=EBI-739895, EBI-10261970;
CC Q8N6Y0; Q8IYX3: CCDC116; NbExp=6; IntAct=EBI-739895, EBI-744311;
CC Q8N6Y0; Q96HB5-4: CCDC120; NbExp=3; IntAct=EBI-739895, EBI-10185348;
CC Q8N6Y0; Q6ZUS5: CCDC121; NbExp=3; IntAct=EBI-739895, EBI-2836982;
CC Q8N6Y0; Q8IYE0: CCDC146; NbExp=3; IntAct=EBI-739895, EBI-10749669;
CC Q8N6Y0; Q8IYE0-2: CCDC146; NbExp=3; IntAct=EBI-739895, EBI-10247802;
CC Q8N6Y0; Q8NFR7: CCDC148; NbExp=3; IntAct=EBI-739895, EBI-2349862;
CC Q8N6Y0; A0A1B0GWI1: CCDC196; NbExp=3; IntAct=EBI-739895, EBI-10181422;
CC Q8N6Y0; Q8NCU1: CCDC197; NbExp=3; IntAct=EBI-739895, EBI-750686;
CC Q8N6Y0; O60826: CCDC22; NbExp=3; IntAct=EBI-739895, EBI-3943153;
CC Q8N6Y0; Q8N4L8: CCDC24; NbExp=6; IntAct=EBI-739895, EBI-1104933;
CC Q8N6Y0; Q7Z6N9: CCDC28A; NbExp=3; IntAct=EBI-739895, EBI-10258115;
CC Q8N6Y0; Q96M95-2: CCDC42; NbExp=3; IntAct=EBI-739895, EBI-11750401;
CC Q8N6Y0; Q9NVE4: CCDC87; NbExp=3; IntAct=EBI-739895, EBI-749261;
CC Q8N6Y0; Q8TD31-3: CCHCR1; NbExp=6; IntAct=EBI-739895, EBI-10175300;
CC Q8N6Y0; Q16543: CDC37; NbExp=3; IntAct=EBI-739895, EBI-295634;
CC Q8N6Y0; Q99459: CDC5L; NbExp=3; IntAct=EBI-739895, EBI-374880;
CC Q8N6Y0; P38936: CDKN1A; NbExp=3; IntAct=EBI-739895, EBI-375077;
CC Q8N6Y0; Q6IPU0: CENPP; NbExp=6; IntAct=EBI-739895, EBI-10250303;
CC Q8N6Y0; Q96MT8-3: CEP63; NbExp=5; IntAct=EBI-739895, EBI-11522539;
CC Q8N6Y0; Q76N32: CEP68; NbExp=3; IntAct=EBI-739895, EBI-9051024;
CC Q8N6Y0; Q76N32-2: CEP68; NbExp=3; IntAct=EBI-739895, EBI-11975967;
CC Q8N6Y0; Q8IYR0: CFAP206; NbExp=3; IntAct=EBI-739895, EBI-749051;
CC Q8N6Y0; Q8NE01: CNNM3; NbExp=3; IntAct=EBI-739895, EBI-741032;
CC Q8N6Y0; Q8NE01-3: CNNM3; NbExp=3; IntAct=EBI-739895, EBI-10269984;
CC Q8N6Y0; Q9BT78: COPS4; NbExp=7; IntAct=EBI-739895, EBI-742413;
CC Q8N6Y0; Q7L5N1: COPS6; NbExp=3; IntAct=EBI-739895, EBI-486838;
CC Q8N6Y0; Q99627: COPS8; NbExp=3; IntAct=EBI-739895, EBI-2510102;
CC Q8N6Y0; Q9UI47-2: CTNNA3; NbExp=3; IntAct=EBI-739895, EBI-11962928;
CC Q8N6Y0; Q9NSA3: CTNNBIP1; NbExp=3; IntAct=EBI-739895, EBI-747082;
CC Q8N6Y0; Q9P2B4: CTTNBP2NL; NbExp=3; IntAct=EBI-739895, EBI-1774273;
CC Q8N6Y0; Q9UIA0: CYTH4; NbExp=3; IntAct=EBI-739895, EBI-11521003;
CC Q8N6Y0; Q13561: DCTN2; NbExp=3; IntAct=EBI-739895, EBI-715074;
CC Q8N6Y0; O75935-2: DCTN3; NbExp=3; IntAct=EBI-739895, EBI-12091947;
CC Q8N6Y0; Q05D60: DEUP1; NbExp=3; IntAct=EBI-739895, EBI-748597;
CC Q8N6Y0; O60941: DTNB; NbExp=3; IntAct=EBI-739895, EBI-740402;
CC Q8N6Y0; O60941-5: DTNB; NbExp=3; IntAct=EBI-739895, EBI-11984733;
CC Q8N6Y0; Q8WWB3: DYDC1; NbExp=7; IntAct=EBI-739895, EBI-740680;
CC Q8N6Y0; O60573: EIF4E2; NbExp=3; IntAct=EBI-739895, EBI-398610;
CC Q8N6Y0; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-739895, EBI-744099;
CC Q8N6Y0; P07992: ERCC1; NbExp=3; IntAct=EBI-739895, EBI-750962;
CC Q8N6Y0; Q9UPT5-1: EXOC7; NbExp=3; IntAct=EBI-739895, EBI-6251402;
CC Q8N6Y0; Q8IYI6: EXOC8; NbExp=5; IntAct=EBI-739895, EBI-742102;
CC Q8N6Y0; O95990-3: FAM107A; NbExp=3; IntAct=EBI-739895, EBI-10192902;
CC Q8N6Y0; Q9BQ89: FAM110A; NbExp=6; IntAct=EBI-739895, EBI-1752811;
CC Q8N6Y0; Q9H5Z6: FAM124B; NbExp=3; IntAct=EBI-739895, EBI-741626;
CC Q8N6Y0; Q96MY7: FAM161B; NbExp=3; IntAct=EBI-739895, EBI-7225287;
CC Q8N6Y0; A0A0S2Z3R2: FANCG; NbExp=3; IntAct=EBI-739895, EBI-16438045;
CC Q8N6Y0; Q8TES7-6: FBF1; NbExp=3; IntAct=EBI-739895, EBI-10244131;
CC Q8N6Y0; O94868-3: FCHSD2; NbExp=3; IntAct=EBI-739895, EBI-11958845;
CC Q8N6Y0; Q96RD9: FCRL5; NbExp=3; IntAct=EBI-739895, EBI-12091825;
CC Q8N6Y0; P02792: FTL; NbExp=3; IntAct=EBI-739895, EBI-713279;
CC Q8N6Y0; O95995: GAS8; NbExp=3; IntAct=EBI-739895, EBI-1052570;
CC Q8N6Y0; Q8WXI9: GATAD2B; NbExp=3; IntAct=EBI-739895, EBI-923440;
CC Q8N6Y0; P55040: GEM; NbExp=3; IntAct=EBI-739895, EBI-744104;
CC Q8N6Y0; Q8NEA9: GMCL2; NbExp=3; IntAct=EBI-739895, EBI-745707;
CC Q8N6Y0; B1APZ0: GNG4; NbExp=3; IntAct=EBI-739895, EBI-10175453;
CC Q8N6Y0; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-739895, EBI-5916454;
CC Q8N6Y0; Q0D2H9: GOLGA8DP; NbExp=3; IntAct=EBI-739895, EBI-10181276;
CC Q8N6Y0; Q08AF8: GOLGA8G; NbExp=3; IntAct=EBI-739895, EBI-10181260;
CC Q8N6Y0; Q9Y4H4: GPSM3; NbExp=3; IntAct=EBI-739895, EBI-347538;
CC Q8N6Y0; Q96CS2: HAUS1; NbExp=3; IntAct=EBI-739895, EBI-2514791;
CC Q8N6Y0; Q9BT25: HAUS8; NbExp=3; IntAct=EBI-739895, EBI-2558143;
CC Q8N6Y0; O14964: HGS; NbExp=4; IntAct=EBI-739895, EBI-740220;
CC Q8N6Y0; Q9NP66: HMG20A; NbExp=3; IntAct=EBI-739895, EBI-740641;
CC Q8N6Y0; Q9P0W2: HMG20B; NbExp=3; IntAct=EBI-739895, EBI-713401;
CC Q8N6Y0; Q8IY31: IFT20; NbExp=3; IntAct=EBI-739895, EBI-744203;
CC Q8N6Y0; Q14005-2: IL16; NbExp=3; IntAct=EBI-739895, EBI-17178971;
CC Q8N6Y0; Q9NV31: IMP3; NbExp=6; IntAct=EBI-739895, EBI-747481;
CC Q8N6Y0; A0A0C4DG38: ING3; NbExp=3; IntAct=EBI-739895, EBI-10263367;
CC Q8N6Y0; Q96HW7: INTS4; NbExp=3; IntAct=EBI-739895, EBI-5663129;
CC Q8N6Y0; Q13352: ITGB3BP; NbExp=3; IntAct=EBI-739895, EBI-712105;
CC Q8N6Y0; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-739895, EBI-2556193;
CC Q8N6Y0; Q2KHM9: KIAA0753; NbExp=3; IntAct=EBI-739895, EBI-2805604;
CC Q8N6Y0; Q6P597-3: KLC3; NbExp=3; IntAct=EBI-739895, EBI-12076930;
CC Q8N6Y0; Q9NSK0: KLC4; NbExp=3; IntAct=EBI-739895, EBI-949319;
CC Q8N6Y0; Q2WGJ6: KLHL38; NbExp=6; IntAct=EBI-739895, EBI-6426443;
CC Q8N6Y0; P52292: KPNA2; NbExp=3; IntAct=EBI-739895, EBI-349938;
CC Q8N6Y0; P02533: KRT14; NbExp=3; IntAct=EBI-739895, EBI-702178;
CC Q8N6Y0; P08779: KRT16; NbExp=3; IntAct=EBI-739895, EBI-356410;
CC Q8N6Y0; P35900: KRT20; NbExp=3; IntAct=EBI-739895, EBI-742094;
CC Q8N6Y0; Q7Z3Y9: KRT26; NbExp=3; IntAct=EBI-739895, EBI-12084444;
CC Q8N6Y0; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-739895, EBI-3044087;
CC Q8N6Y0; Q7Z3Y7: KRT28; NbExp=3; IntAct=EBI-739895, EBI-11980489;
CC Q8N6Y0; Q15323: KRT31; NbExp=3; IntAct=EBI-739895, EBI-948001;
CC Q8N6Y0; O76014: KRT37; NbExp=3; IntAct=EBI-739895, EBI-1045716;
CC Q8N6Y0; O76015: KRT38; NbExp=6; IntAct=EBI-739895, EBI-1047263;
CC Q8N6Y0; Q6A162: KRT40; NbExp=3; IntAct=EBI-739895, EBI-10171697;
CC Q8N6Y0; Q3SY84: KRT71; NbExp=3; IntAct=EBI-739895, EBI-2952676;
CC Q8N6Y0; O95678: KRT75; NbExp=3; IntAct=EBI-739895, EBI-2949715;
CC Q8N6Y0; Q5XKE5: KRT79; NbExp=3; IntAct=EBI-739895, EBI-2514135;
CC Q8N6Y0; Q96BZ8: LENG1; NbExp=3; IntAct=EBI-739895, EBI-726510;
CC Q8N6Y0; Q96FQ7: LINC00526; NbExp=3; IntAct=EBI-739895, EBI-10286106;
CC Q8N6Y0; O15481: MAGEB4; NbExp=6; IntAct=EBI-739895, EBI-751857;
CC Q8N6Y0; P59942: MCCD1; NbExp=3; IntAct=EBI-739895, EBI-11987923;
CC Q8N6Y0; P33993: MCM7; NbExp=3; IntAct=EBI-739895, EBI-355924;
CC Q8N6Y0; Q96EZ8: MCRS1; NbExp=6; IntAct=EBI-739895, EBI-348259;
CC Q8N6Y0; Q9P086: MED11; NbExp=3; IntAct=EBI-739895, EBI-394704;
CC Q8N6Y0; Q9NPJ6: MED4; NbExp=6; IntAct=EBI-739895, EBI-394607;
CC Q8N6Y0; A8MW99: MEI4; NbExp=3; IntAct=EBI-739895, EBI-19944212;
CC Q8N6Y0; A6NJ78-4: METTL15; NbExp=3; IntAct=EBI-739895, EBI-10174029;
CC Q8N6Y0; Q8IVT4: MGC50722; NbExp=3; IntAct=EBI-739895, EBI-14086479;
CC Q8N6Y0; Q5JXC2: MIIP; NbExp=5; IntAct=EBI-739895, EBI-2801965;
CC Q8N6Y0; Q13064: MKRN3; NbExp=3; IntAct=EBI-739895, EBI-2340269;
CC Q8N6Y0; Q8NEH6: MNS1; NbExp=3; IntAct=EBI-739895, EBI-743811;
CC Q8N6Y0; P00540: MOS; NbExp=6; IntAct=EBI-739895, EBI-1757866;
CC Q8N6Y0; Q9Y3D9: MRPS23; NbExp=3; IntAct=EBI-739895, EBI-1054270;
CC Q8N6Y0; P50539-4: MXI1; NbExp=3; IntAct=EBI-739895, EBI-16436111;
CC Q8N6Y0; P15173: MYOG; NbExp=5; IntAct=EBI-739895, EBI-3906629;
CC Q8N6Y0; Q9NP98: MYOZ1; NbExp=3; IntAct=EBI-739895, EBI-744402;
CC Q8N6Y0; Q6IBW4-4: NCAPH2; NbExp=3; IntAct=EBI-739895, EBI-10247000;
CC Q8N6Y0; O14777: NDC80; NbExp=4; IntAct=EBI-739895, EBI-715849;
CC Q8N6Y0; Q7Z6G3-2: NECAB2; NbExp=3; IntAct=EBI-739895, EBI-10172876;
CC Q8N6Y0; I6L9F6: NEFL; NbExp=3; IntAct=EBI-739895, EBI-10178578;
CC Q8N6Y0; Q9BVI4: NOC4L; NbExp=2; IntAct=EBI-739895, EBI-395927;
CC Q8N6Y0; P37198: NUP62; NbExp=3; IntAct=EBI-739895, EBI-347978;
CC Q8N6Y0; A5D8V7: ODAD3; NbExp=3; IntAct=EBI-739895, EBI-8466445;
CC Q8N6Y0; O43482: OIP5; NbExp=3; IntAct=EBI-739895, EBI-536879;
CC Q8N6Y0; Q9HBI0: PARVG; NbExp=6; IntAct=EBI-739895, EBI-3921217;
CC Q8N6Y0; P26367: PAX6; NbExp=3; IntAct=EBI-739895, EBI-747278;
CC Q8N6Y0; Q9BYU1: PBX4; NbExp=3; IntAct=EBI-739895, EBI-10302990;
CC Q8N6Y0; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-739895, EBI-79165;
CC Q8N6Y0; Q16512: PKN1; NbExp=3; IntAct=EBI-739895, EBI-602382;
CC Q8N6Y0; Q96KN3: PKNOX2; NbExp=3; IntAct=EBI-739895, EBI-2692890;
CC Q8N6Y0; Q6P1K2: PMF1; NbExp=3; IntAct=EBI-739895, EBI-713832;
CC Q8N6Y0; Q6PIY2: POLM; NbExp=3; IntAct=EBI-739895, EBI-10253863;
CC Q8N6Y0; Q969H6: POP5; NbExp=3; IntAct=EBI-739895, EBI-366525;
CC Q8N6Y0; Q9BZL4: PPP1R12C; NbExp=3; IntAct=EBI-739895, EBI-721802;
CC Q8N6Y0; Q15435: PPP1R7; NbExp=3; IntAct=EBI-739895, EBI-1024281;
CC Q8N6Y0; Q15172: PPP2R5A; NbExp=3; IntAct=EBI-739895, EBI-641666;
CC Q8N6Y0; Q14738: PPP2R5D; NbExp=3; IntAct=EBI-739895, EBI-396563;
CC Q8N6Y0; P54646: PRKAA2; NbExp=3; IntAct=EBI-739895, EBI-1383852;
CC Q8N6Y0; P85299-2: PRR5; NbExp=3; IntAct=EBI-739895, EBI-12944296;
CC Q8N6Y0; P47897: QARS1; NbExp=3; IntAct=EBI-739895, EBI-347462;
CC Q8N6Y0; Q9UJF2: RASAL2; NbExp=3; IntAct=EBI-739895, EBI-359444;
CC Q8N6Y0; Q9P2K3-2: RCOR3; NbExp=3; IntAct=EBI-739895, EBI-1504830;
CC Q8N6Y0; Q6P9E2: RECK; NbExp=3; IntAct=EBI-739895, EBI-10253121;
CC Q8N6Y0; Q8N443: RIBC1; NbExp=3; IntAct=EBI-739895, EBI-10265323;
CC Q8N6Y0; Q6NUQ1: RINT1; NbExp=3; IntAct=EBI-739895, EBI-726876;
CC Q8N6Y0; Q5VTR2: RNF20; NbExp=3; IntAct=EBI-739895, EBI-2372238;
CC Q8N6Y0; Q14D33: RTP5; NbExp=3; IntAct=EBI-739895, EBI-10217913;
CC Q8N6Y0; Q86UD0: SAPCD2; NbExp=3; IntAct=EBI-739895, EBI-2561646;
CC Q8N6Y0; P21673: SAT1; NbExp=3; IntAct=EBI-739895, EBI-711613;
CC Q8N6Y0; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-739895, EBI-748391;
CC Q8N6Y0; P09683: SCT; NbExp=3; IntAct=EBI-739895, EBI-12844598;
CC Q8N6Y0; Q9UDX3: SEC14L4; NbExp=6; IntAct=EBI-739895, EBI-10320311;
CC Q8N6Y0; Q9C0C4: SEMA4C; NbExp=3; IntAct=EBI-739895, EBI-10303490;
CC Q8N6Y0; Q9UJW9: SERTAD3; NbExp=7; IntAct=EBI-739895, EBI-748621;
CC Q8N6Y0; Q9H788-2: SH2D4A; NbExp=3; IntAct=EBI-739895, EBI-10308083;
CC Q8N6Y0; Q92529: SHC3; NbExp=3; IntAct=EBI-739895, EBI-79084;
CC Q8N6Y0; Q96GM5: SMARCD1; NbExp=4; IntAct=EBI-739895, EBI-358489;
CC Q8N6Y0; Q969G3: SMARCE1; NbExp=3; IntAct=EBI-739895, EBI-455078;
CC Q8N6Y0; Q5JUK2: SOHLH1; NbExp=3; IntAct=EBI-739895, EBI-12288855;
CC Q8N6Y0; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-739895, EBI-742688;
CC Q8N6Y0; Q6ZRS2-3: SRCAP; NbExp=3; IntAct=EBI-739895, EBI-12029182;
CC Q8N6Y0; P30626: SRI; NbExp=3; IntAct=EBI-739895, EBI-750459;
CC Q8N6Y0; O75558: STX11; NbExp=3; IntAct=EBI-739895, EBI-714135;
CC Q8N6Y0; P57105: SYNJ2BP; NbExp=6; IntAct=EBI-739895, EBI-1049004;
CC Q8N6Y0; Q5VWN6: TASOR2; NbExp=3; IntAct=EBI-739895, EBI-745958;
CC Q8N6Y0; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-739895, EBI-11955057;
CC Q8N6Y0; Q9BT92: TCHP; NbExp=3; IntAct=EBI-739895, EBI-740781;
CC Q8N6Y0; Q969V4: TEKT1; NbExp=3; IntAct=EBI-739895, EBI-10180409;
CC Q8N6Y0; Q6YHU6: THADA; NbExp=3; IntAct=EBI-739895, EBI-2824523;
CC Q8N6Y0; Q96FV9: THOC1; NbExp=3; IntAct=EBI-739895, EBI-1765605;
CC Q8N6Y0; Q9Y5L4: TIMM13; NbExp=3; IntAct=EBI-739895, EBI-1057344;
CC Q8N6Y0; Q8N7U7-2: TPRX1; NbExp=3; IntAct=EBI-739895, EBI-14115717;
CC Q8N6Y0; Q9BYV2: TRIM54; NbExp=6; IntAct=EBI-739895, EBI-2130429;
CC Q8N6Y0; Q8N7C3: TRIML2; NbExp=3; IntAct=EBI-739895, EBI-11059915;
CC Q8N6Y0; Q99816: TSG101; NbExp=3; IntAct=EBI-739895, EBI-346882;
CC Q8N6Y0; Q5W5X9-3: TTC23; NbExp=3; IntAct=EBI-739895, EBI-9090990;
CC Q8N6Y0; Q8N5M4: TTC9C; NbExp=3; IntAct=EBI-739895, EBI-2851213;
CC Q8N6Y0; Q6ZVT0-3: TTLL10; NbExp=3; IntAct=EBI-739895, EBI-11979997;
CC Q8N6Y0; P40222: TXLNA; NbExp=6; IntAct=EBI-739895, EBI-359793;
CC Q8N6Y0; Q8N3L3: TXLNB; NbExp=6; IntAct=EBI-739895, EBI-6116822;
CC Q8N6Y0; Q96B02: UBE2W; NbExp=3; IntAct=EBI-739895, EBI-716589;
CC Q8N6Y0; Q96FI0: UBE2W; NbExp=3; IntAct=EBI-739895, EBI-10285774;
CC Q8N6Y0; Q5T124: UBXN11; NbExp=3; IntAct=EBI-739895, EBI-746004;
CC Q8N6Y0; Q5T124-6: UBXN11; NbExp=3; IntAct=EBI-739895, EBI-11524408;
CC Q8N6Y0; O75604: USP2; NbExp=3; IntAct=EBI-739895, EBI-743272;
CC Q8N6Y0; Q548N1: VPS28; NbExp=3; IntAct=EBI-739895, EBI-10243107;
CC Q8N6Y0; Q9UK41: VPS28; NbExp=6; IntAct=EBI-739895, EBI-727424;
CC Q8N6Y0; B2RXF5: ZBTB42; NbExp=3; IntAct=EBI-739895, EBI-12287587;
CC Q8N6Y0; Q15911-2: ZFHX3; NbExp=3; IntAct=EBI-739895, EBI-10237226;
CC Q8N6Y0; Q68DK2-5: ZFYVE26; NbExp=6; IntAct=EBI-739895, EBI-8656416;
CC Q8N6Y0; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-739895, EBI-740727;
CC Q8N6Y0; Q6P088: ZNF483; NbExp=3; IntAct=EBI-739895, EBI-10196963;
CC Q8N6Y0; Q8N720: ZNF655; NbExp=3; IntAct=EBI-739895, EBI-625509;
CC Q8N6Y0; A0A0S2Z5X4: ZNF688; NbExp=3; IntAct=EBI-739895, EBI-16429014;
CC Q8N6Y0; A0A0S2Z6P0: ZNF688; NbExp=3; IntAct=EBI-739895, EBI-16429989;
CC Q8N6Y0; Q7L2R6: ZNF765; NbExp=3; IntAct=EBI-739895, EBI-9676069;
CC Q8N6Y0; G4XUV3; NbExp=3; IntAct=EBI-739895, EBI-10177989;
CC Q8N6Y0; Q8N9J2; NbExp=3; IntAct=EBI-739895, EBI-10268244;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1 {ECO:0000269|PubMed:11311560, ECO:0000269|PubMed:14702039,
CC ECO:0000269|PubMed:15489334};
CC IsoId=Q8N6Y0-1; Sequence=Displayed;
CC Name=2 {ECO:0000269|PubMed:11311560};
CC IsoId=Q8N6Y0-2; Sequence=VSP_052080;
CC -!- TISSUE SPECIFICITY: Highest level of expression in heart, and moderate
CC to low expression in skeletal muscle, kidney, liver, small intestine,
CC placenta and lung. {ECO:0000269|PubMed:11311560}.
CC -!- MISCELLANEOUS: [Isoform 2]: Due to the retention of an intron in the
CC cDNA leading to a prematurate stop codon.
CC {ECO:0000269|PubMed:11311560}.
CC -!- SIMILARITY: Belongs to the MCC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC11443.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB026290; BAB41203.1; -; mRNA.
DR EMBL; AB040046; BAB43978.1; -; mRNA.
DR EMBL; AK075162; BAC11443.1; ALT_INIT; mRNA.
DR EMBL; AK292031; BAF84720.1; -; mRNA.
DR EMBL; AK315239; BAG37666.1; -; mRNA.
DR EMBL; BC027910; AAH27910.1; -; mRNA.
DR CCDS; CCDS12353.1; -. [Q8N6Y0-1]
DR RefSeq; NP_001284632.1; NM_001297703.1.
DR RefSeq; NP_001308346.1; NM_001321417.1. [Q8N6Y0-1]
DR RefSeq; NP_114147.2; NM_031941.3. [Q8N6Y0-1]
DR AlphaFoldDB; Q8N6Y0; -.
DR SMR; Q8N6Y0; -.
DR BioGRID; 123791; 251.
DR IntAct; Q8N6Y0; 252.
DR MINT; Q8N6Y0; -.
DR STRING; 9606.ENSP00000252597; -.
DR iPTMnet; Q8N6Y0; -.
DR PhosphoSitePlus; Q8N6Y0; -.
DR BioMuta; USHBP1; -.
DR DMDM; 74729194; -.
DR EPD; Q8N6Y0; -.
DR MassIVE; Q8N6Y0; -.
DR PaxDb; Q8N6Y0; -.
DR PeptideAtlas; Q8N6Y0; -.
DR PRIDE; Q8N6Y0; -.
DR ProteomicsDB; 72246; -. [Q8N6Y0-1]
DR Antibodypedia; 65308; 41 antibodies from 14 providers.
DR DNASU; 83878; -.
DR Ensembl; ENST00000252597.8; ENSP00000252597.2; ENSG00000130307.12. [Q8N6Y0-1]
DR Ensembl; ENST00000597928.5; ENSP00000469562.1; ENSG00000130307.12. [Q8N6Y0-2]
DR GeneID; 83878; -.
DR KEGG; hsa:83878; -.
DR MANE-Select; ENST00000252597.8; ENSP00000252597.2; NM_031941.4; NP_114147.2.
DR UCSC; uc002nfs.2; human. [Q8N6Y0-1]
DR CTD; 83878; -.
DR DisGeNET; 83878; -.
DR GeneCards; USHBP1; -.
DR HGNC; HGNC:24058; USHBP1.
DR HPA; ENSG00000130307; Low tissue specificity.
DR MIM; 611810; gene.
DR neXtProt; NX_Q8N6Y0; -.
DR OpenTargets; ENSG00000130307; -.
DR PharmGKB; PA134909077; -.
DR VEuPathDB; HostDB:ENSG00000130307; -.
DR eggNOG; KOG3512; Eukaryota.
DR GeneTree; ENSGT00530000063974; -.
DR HOGENOM; CLU_024579_0_0_1; -.
DR InParanoid; Q8N6Y0; -.
DR OMA; HKAWRSD; -.
DR PhylomeDB; Q8N6Y0; -.
DR TreeFam; TF105384; -.
DR PathwayCommons; Q8N6Y0; -.
DR SignaLink; Q8N6Y0; -.
DR BioGRID-ORCS; 83878; 21 hits in 1067 CRISPR screens.
DR ChiTaRS; USHBP1; human.
DR GenomeRNAi; 83878; -.
DR Pharos; Q8N6Y0; Tbio.
DR PRO; PR:Q8N6Y0; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8N6Y0; protein.
DR Bgee; ENSG00000130307; Expressed in apex of heart and 104 other tissues.
DR ExpressionAtlas; Q8N6Y0; baseline and differential.
DR Genevisible; Q8N6Y0; HS.
DR GO; GO:0030165; F:PDZ domain binding; IPI:HGNC-UCL.
DR InterPro; IPR040171; USBP1-like.
DR InterPro; IPR019536; USH1C-bd_PDZ_domain.
DR PANTHER; PTHR23347; PTHR23347; 1.
DR Pfam; PF10506; MCC-bdg_PDZ; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..703
FT /note="Harmonin-binding protein USHBP1"
FT /id="PRO_0000252109"
FT REGION 1..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 138..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 396..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 540..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 189..227
FT /evidence="ECO:0000255"
FT COILED 289..309
FT /evidence="ECO:0000255"
FT COILED 476..513
FT /evidence="ECO:0000255"
FT COILED 596..681
FT /evidence="ECO:0000255"
FT COMPBIAS 234..249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..416
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 69..703
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11311560"
FT /id="VSP_052080"
FT VARIANT 439
FT /note="M -> V (in dbSNP:rs9676419)"
FT /evidence="ECO:0000269|PubMed:11311560"
FT /id="VAR_027753"
FT VARIANT 525
FT /note="V -> M (in dbSNP:rs12459398)"
FT /id="VAR_027754"
FT VARIANT 677
FT /note="A -> V (in dbSNP:rs1043963)"
FT /id="VAR_051481"
FT CONFLICT 233
FT /note="H -> R (in Ref. 2; BAF84720)"
FT /evidence="ECO:0000305"
FT CONFLICT 400
FT /note="A -> T (in Ref. 1; BAB41203)"
FT /evidence="ECO:0000305"
FT CONFLICT 454
FT /note="T -> I (in Ref. 1; BAB41203)"
FT /evidence="ECO:0000305"
FT CONFLICT 572
FT /note="G -> D (in Ref. 2; BAG37666)"
FT /evidence="ECO:0000305"
FT CONFLICT 586
FT /note="D -> G (in Ref. 3; BAC11443)"
FT /evidence="ECO:0000305"
FT CONFLICT 633
FT /note="N -> S (in Ref. 3; BAC11443)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 703 AA; 76068 MW; 75BD22E490DC1467 CRC64;
MSARATRPRS RRGRHAPPGE LDPVAESSEE VEAASGSSKP SFAPPPVSSG LEQLGPMEEV
SGQGLGSRTD KKMDGGSGRE LASAPEVPHK PAVEAHQAPE AALQYKETVP PGNGAPDVFQ
TLQHTLSSLE AAAAAWRHQP PSHSGPMEFE GTSEGGAGSL GKQEGAGSCQ REAARLAERN
AWLRLALSSR EDELVRTQAS LEAIRAEKET LQKEVQELQD SLLRLEPCPH LSHNQAGGSG
SGSSSSEADR EPWETQDSFS LAHPLLRRLR SHSSTQILGS LPNQPLSPEM HIMEAQMEQL
RGSIEKLKCF NRLLSAVLQG YKGRCEGLSM QLGQREAEAT ALHLALQYSE HCEEAYRVLL
ALREADSGAG DEAPMSDLQA AEKEAWRLLA QEEAAMDAGA QQNPQPSPEG SSVDKPTPQE
VAFQLRSYVQ RLQERRSLMK ILSEPGPTLA PMPTVPRAEA MVQAILGTQA GPALPRLEKT
QIQQDLVAAR EALADLMLRL QLVRREKRGL ELREAALRAL GPAHVLLLEQ LRWERAELQA
GGANSSGGHS SGGGSSGDEE EWYQGLPAVP GGTSGIDGGQ VGRAWDPEKL AQELAASLTR
TLDLQEQLQS LRRELEQVAQ KGRARRSQSA ELNRDLCKAH SALVLAFRGA HRKQEEQRRK
LEQQMALMEA QQAEEVAVLE ATARALGKPR PPLPPPQLGD TFL
