USBP1_MOUSE
ID USBP1_MOUSE Reviewed; 680 AA.
AC Q8R370; E9QKT2;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Harmonin-binding protein USHBP1 {ECO:0000305};
DE AltName: Full=Usher syndrome type-1C protein-binding protein 1;
DE Short=USH1C-binding protein 1;
GN Name=Ushbp1 {ECO:0000312|EMBL:AAH26453.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000312|EMBL:AAH26453.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N {ECO:0000312|EMBL:AAH26453.1};
RC TISSUE=Mammary gland {ECO:0000312|EMBL:AAH26453.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PROTEIN SEQUENCE OF 324-332, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=OF1; TISSUE=Hippocampus;
RA Lubec G., Sunyer B., Chen W.-Q.;
RL Submitted (JAN-2009) to UniProtKB.
CC -!- SUBUNIT: Interacts via its C-terminus with the first PDZ domain of
CC USH1C. {ECO:0000250|UniProtKB:Q8N6Y0}.
CC -!- SIMILARITY: Belongs to the MCC family. {ECO:0000305}.
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DR EMBL; AC127416; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC026453; AAH26453.1; -; mRNA.
DR CCDS; CCDS22393.1; -.
DR RefSeq; NP_852083.2; NM_181418.3.
DR AlphaFoldDB; Q8R370; -.
DR SMR; Q8R370; -.
DR STRING; 10090.ENSMUSP00000045668; -.
DR iPTMnet; Q8R370; -.
DR PhosphoSitePlus; Q8R370; -.
DR MaxQB; Q8R370; -.
DR PaxDb; Q8R370; -.
DR PRIDE; Q8R370; -.
DR ProteomicsDB; 297900; -.
DR Antibodypedia; 65308; 41 antibodies from 14 providers.
DR DNASU; 234395; -.
DR Ensembl; ENSMUST00000049184; ENSMUSP00000045668; ENSMUSG00000034911.
DR GeneID; 234395; -.
DR KEGG; mmu:234395; -.
DR UCSC; uc009mcz.2; mouse.
DR CTD; 83878; -.
DR MGI; MGI:1922920; Ushbp1.
DR VEuPathDB; HostDB:ENSMUSG00000034911; -.
DR eggNOG; KOG3512; Eukaryota.
DR GeneTree; ENSGT00530000063974; -.
DR HOGENOM; CLU_024579_0_0_1; -.
DR InParanoid; Q8R370; -.
DR OMA; HKAWRSD; -.
DR OrthoDB; 787084at2759; -.
DR PhylomeDB; Q8R370; -.
DR TreeFam; TF105384; -.
DR BioGRID-ORCS; 234395; 4 hits in 72 CRISPR screens.
DR PRO; PR:Q8R370; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8R370; protein.
DR Bgee; ENSMUSG00000034911; Expressed in interventricular septum and 122 other tissues.
DR ExpressionAtlas; Q8R370; baseline and differential.
DR Genevisible; Q8R370; MM.
DR GO; GO:0030165; F:PDZ domain binding; ISO:MGI.
DR InterPro; IPR040171; USBP1-like.
DR InterPro; IPR019536; USH1C-bd_PDZ_domain.
DR PANTHER; PTHR23347; PTHR23347; 1.
DR Pfam; PF10506; MCC-bdg_PDZ; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Direct protein sequencing; Reference proteome.
FT CHAIN 1..680
FT /note="Harmonin-binding protein USHBP1"
FT /id="PRO_0000252110"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 134..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 220..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 384..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 524..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 179..218
FT /evidence="ECO:0000255"
FT COILED 363..386
FT /evidence="ECO:0000255"
FT COILED 467..506
FT /evidence="ECO:0000255"
FT COILED 573..662
FT /evidence="ECO:0000255"
FT COMPBIAS 134..159
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 37
FT /note="R -> C (in Ref. 2; AAH26453)"
FT /evidence="ECO:0000305"
FT CONFLICT 249
FT /note="S -> P (in Ref. 2; AAH26453)"
FT /evidence="ECO:0000305"
FT CONFLICT 379
FT /note="M -> V (in Ref. 2; AAH26453)"
FT /evidence="ECO:0000305"
FT CONFLICT 409
FT /note="S -> V (in Ref. 2; AAH26453)"
FT /evidence="ECO:0000305"
FT CONFLICT 478
FT /note="R -> S (in Ref. 2; AAH26453)"
FT /evidence="ECO:0000305"
FT CONFLICT 540
FT /note="E -> D (in Ref. 2; AAH26453)"
FT /evidence="ECO:0000305"
FT CONFLICT 594
FT /note="Q -> R (in Ref. 2; AAH26453)"
FT /evidence="ECO:0000305"
FT CONFLICT 640
FT /note="L -> R (in Ref. 2; AAH26453)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 680 AA; 74906 MW; A4A8419B843FAE2F CRC64;
MSARATRPRS RRGRHPLPGE LDPVAESSEE VDANNGRFET KPELHQEYLG PGLQSPRNWI
KEGCDVGSHA VLSLSPEEQC EPEVEAHQVL QEAPLDSGPA EISVPSVYET LQCRLSSLEA
VVAALRHHSL SFPKSVEAED RDQGAPGPFG DEKEDAGPGQ QEAARLIERN AWLRLALCNR
EDELACTQAS LQDAQAEKET LQRQVQELED SLMQMEASPP TPILRAGRRN SNSSTSGAER
RPWVPQDSSM AHPFLQRLRS DSSTQSFGCL STQHPAPETY LMEDQMGQLQ GSIEKLKCFN
RLLLAVLQGY KGRCESLSIK LAKREAEATA LRLALQYSED CEEVYEVLLA LKMAGLGTGV
GTTKGDLQAA EKEASRLLMK KEATMEVETP QPSSEGSGVD KPTPEELASQ LHGYVQHLRE
RWALVKIPEE LGPVTAPKAT MPHAEATVQA ILEIQPGPTL PHLEKSQIQQ DLAATRDRLA
DLVLRLQLTQ REKRGLELRE AALRAQGPAH QLLLQQLRWE RAHFAGDGSS GGSSEDPSSE
EEAGEDRQQH YQGPLALLDG QMGKVWDSEN VSQELSASLA RAIDLRAQLQ SLRQQLEQVT
QKGRTRRVQS AELSRELCKA HSALALAFRG AHRKQEEQRL KLEQQVARLQ AQQAEELAVL
TATARALGKP GAPQPAQTFL
