ID   USE1_CAEEL              Reviewed;         254 AA.
AC   Q9N598;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 2.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Vesicle transport protein USE1;
DE   AltName: Full=USE1-like protein;
GN   ORFNames=Y110A7A.11;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: SNARE that may be involved in targeting and fusion of Golgi-
CC       derived retrograde transport vesicles with the ER. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass type IV membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the USE1 family. {ECO:0000305}.
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DR   EMBL; BX284601; CCD66202.1; -; Genomic_DNA.
DR   RefSeq; NP_491521.2; NM_059120.6.
DR   AlphaFoldDB; Q9N598; -.
DR   SMR; Q9N598; -.
DR   BioGRID; 37601; 1.
DR   STRING; 6239.Y110A7A.11; -.
DR   EPD; Q9N598; -.
DR   PaxDb; Q9N598; -.
DR   PeptideAtlas; Q9N598; -.
DR   EnsemblMetazoa; Y110A7A.11.1; Y110A7A.11.1; WBGene00022460.
DR   GeneID; 172140; -.
DR   KEGG; cel:CELE_Y110A7A.11; -.
DR   UCSC; Y110A7A.11; c. elegans.
DR   CTD; 172140; -.
DR   WormBase; Y110A7A.11; CE34394; WBGene00022460; use-1.
DR   eggNOG; KOG2678; Eukaryota.
DR   GeneTree; ENSGT00390000014361; -.
DR   HOGENOM; CLU_1107913_0_0_1; -.
DR   InParanoid; Q9N598; -.
DR   OMA; AYRSWCD; -.
DR   OrthoDB; 1500600at2759; -.
DR   PhylomeDB; Q9N598; -.
DR   Reactome; R-CEL-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR   PRO; PR:Q9N598; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00022460; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR   GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IBA:GO_Central.
DR   InterPro; IPR019150; Vesicle_transport_protein_Use1.
DR   PANTHER; PTHR13050; PTHR13050; 1.
DR   Pfam; PF09753; Use1; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; ER-Golgi transport; Membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..254
FT                   /note="Vesicle transport protein USE1"
FT                   /id="PRO_0000215583"
FT   TOPO_DOM        1..228
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        229..249
FT                   /note="Helical; Anchor for type IV membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        250..254
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   254 AA;  29222 MW;  BA999D34DCD7CA2A CRC64;
     MAYISENELK FLRLLERTKR LTKEDMSANV WKVSAATKIL NKMIYTLQND ETTNDILHEY
     RQEVLQLKLL AEAESKSSAE ERLKVIEKIP RVFPDVQVTV ADSKNDNEAE SYDFEKESAA
     GLRATQRSIY RSDLRKQLLS SNKHRAQDTS EDQEFMKNEL VEEELANSLA TMARSFKTMM
     SAAGDVIKED TERAILMAKE VDDNKTALGI QSERVERHAY KCGYDCFKVM LIVLIFMSFV
     SMVLMMKIFK KAST