ID   USE1_SCHPO              Reviewed;         222 AA.
AC   O13785;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Protein transport protein use1;
GN   Name=use1; ORFNames=SPAC17G6.07c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: SNARE required for targeting and fusion of Golgi-derived
CC       retrograde transport vesicles with the ER. {ECO:0000250}.
CC   -!- SUBUNIT: Component of a SNARE complex consisting of ufe1, use1, sec20
CC       and sec22 or ykt6. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass type IV membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the USE1 family. {ECO:0000305}.
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DR   EMBL; CU329670; CAB16218.1; -; Genomic_DNA.
DR   PIR; T37839; T37839.
DR   RefSeq; NP_594254.1; NM_001019677.2.
DR   AlphaFoldDB; O13785; -.
DR   SMR; O13785; -.
DR   BioGRID; 278861; 3.
DR   STRING; 4896.SPAC17G6.07c.1; -.
DR   MaxQB; O13785; -.
DR   PaxDb; O13785; -.
DR   EnsemblFungi; SPAC17G6.07c.1; SPAC17G6.07c.1:pep; SPAC17G6.07c.
DR   GeneID; 2542397; -.
DR   KEGG; spo:SPAC17G6.07c; -.
DR   PomBase; SPAC17G6.07c; use1.
DR   VEuPathDB; FungiDB:SPAC17G6.07c; -.
DR   eggNOG; KOG2678; Eukaryota.
DR   HOGENOM; CLU_1251310_0_0_1; -.
DR   InParanoid; O13785; -.
DR   OMA; WEEGKCQ; -.
DR   PhylomeDB; O13785; -.
DR   Reactome; R-SPO-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR   PRO; PR:O13785; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:PomBase.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR   GO; GO:0005484; F:SNAP receptor activity; ISS:PomBase.
DR   GO; GO:0006886; P:intracellular protein transport; NAS:PomBase.
DR   GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; ISS:PomBase.
DR   InterPro; IPR019150; Vesicle_transport_protein_Use1.
DR   PANTHER; PTHR13050; PTHR13050; 1.
DR   Pfam; PF09753; Use1; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; ER-Golgi transport; Membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..222
FT                   /note="Protein transport protein use1"
FT                   /id="PRO_0000116727"
FT   TOPO_DOM        1..193
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..214
FT                   /note="Helical; Anchor for type IV membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        215..222
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   222 AA;  25829 MW;  AD8E96F81C2591F5 CRC64;
     MSKDLISRLE RQFKLKRDEF QDPLELLKFE KNLDYARKLL WEEGKCQLDK VAEPQGLSKR
     IMDLQGRIYD LNVTMEKKLK IEEKKIKSKQ EKEIAHALQS IQERELRERQ QMSNVEASNA
     QLLTNQRSMQ TEISESLLHL ASVLKENALS FTNALVTDNQ VVERTGSLLD KNAHSLRHAN
     HGVQSYSKSK RLSFWLQLGM IIAVVVSFIV MIFILQFTKN QN