ID   USF1_BOVIN              Reviewed;         310 AA.
AC   Q6XBT4;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Upstream stimulatory factor 1;
GN   Name=USF1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Ovarian follicle;
RX   PubMed=14660559; DOI=10.1074/jbc.m311222200;
RA   Sayasith K., Bouchard N., Sawadogo M., Lussier J.G., Sirois J.;
RT   "Molecular characterization and role of bovine upstream stimulatory factor
RT   1 and 2 in the regulation of the prostaglandin G/H synthase-2 promoter in
RT   granulosa cells.";
RL   J. Biol. Chem. 279:6327-6336(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor that binds to a symmetrical DNA sequence
CC       (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and
CC       cellular promoters. {ECO:0000250}.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein. Binds DNA as a homodimer or a heterodimer (USF1/USF2) (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
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DR   EMBL; AY241931; AAP43041.1; -; mRNA.
DR   EMBL; BC114684; AAI14685.1; -; mRNA.
DR   RefSeq; NP_001001161.1; NM_001001161.2.
DR   RefSeq; XP_005203512.1; XM_005203455.2.
DR   RefSeq; XP_005203513.1; XM_005203456.3.
DR   RefSeq; XP_005203514.1; XM_005203457.3.
DR   RefSeq; XP_015316732.1; XM_015461246.1.
DR   AlphaFoldDB; Q6XBT4; -.
DR   SMR; Q6XBT4; -.
DR   STRING; 9913.ENSBTAP00000023760; -.
DR   PaxDb; Q6XBT4; -.
DR   PRIDE; Q6XBT4; -.
DR   Ensembl; ENSBTAT00000023760; ENSBTAP00000023760; ENSBTAG00000017873.
DR   GeneID; 407239; -.
DR   KEGG; bta:407239; -.
DR   CTD; 7391; -.
DR   VEuPathDB; HostDB:ENSBTAG00000017873; -.
DR   VGNC; VGNC:55695; USF1.
DR   eggNOG; KOG1318; Eukaryota.
DR   GeneTree; ENSGT00940000157083; -.
DR   HOGENOM; CLU_070485_0_0_1; -.
DR   InParanoid; Q6XBT4; -.
DR   OMA; KTIPECN; -.
DR   OrthoDB; 1345445at2759; -.
DR   TreeFam; TF323338; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000017873; Expressed in leukocyte and 106 other tissues.
DR   GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR   GO; GO:0043425; F:bHLH transcription factor binding; IEA:Ensembl.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0042826; F:histone deacetylase binding; IEA:Ensembl.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR   GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0032869; P:cellular response to insulin stimulus; IEA:Ensembl.
DR   GO; GO:0019086; P:late viral transcription; IEA:Ensembl.
DR   GO; GO:0055088; P:lipid homeostasis; IEA:Ensembl.
DR   GO; GO:0000432; P:positive regulation of transcription from RNA polymerase II promoter by glucose; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0009411; P:response to UV; IEA:Ensembl.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Isopeptide bond; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Ubl conjugation.
FT   CHAIN           1..310
FT                   /note="Upstream stimulatory factor 1"
FT                   /id="PRO_0000244425"
FT   DOMAIN          199..254
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          171..209
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          271..292
FT                   /note="Leucine-zipper"
FT   COMPBIAS        190..209
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CROSSLNK        306
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:P22415"
SQ   SEQUENCE   310 AA;  33497 MW;  BFC663406B4B80AE CRC64;
     MKGQQKTAET EEGTVQIQEG AVATGEDPTS VAIASIQSAA TFPDPNVKYV FRTENGGQVM
     YRVIQVSEGQ LDGQTEGTGA ISGYPATQSM TQAVIQGAFT SDDAVDTEGT AAETHYTYFP
     STAVGDGAGG TTSGSTAAVV TTQGSEALLG QATPPGTGQF FVMMSPQEVL QGGSQRSIAP
     RTHPYSPKSE APRTTRDEKR RAQHNEVERR RRDKINNWIV QLSKIIPDCS MESTKSGQSK
     GGILSKACDY IQELRQSNHR LSEELQGLDQ LQLDNDVLRQ QVEDLKNKNL LLRAQLRHHG
     VEVVIKSDSN