USF1_MOUSE
ID USF1_MOUSE Reviewed; 310 AA.
AC Q61069;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Upstream stimulatory factor 1;
DE AltName: Full=Major late transcription factor 1;
GN Name=Usf1; Synonyms=Usf;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=8938446; DOI=10.1006/geno.1996.0568;
RA Aperlo C., Boulukos K.E., Sage J., Cuzin F., Pognonec P.;
RT "Complete sequencing of the murine USF gene and comparison of its genomic
RT organization to that of mFIP/USF2.";
RL Genomics 37:337-344(1996).
CC -!- FUNCTION: Transcription factor that binds to a symmetrical DNA sequence
CC (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and
CC cellular promoters.
CC -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC protein. Binds DNA as a homodimer or a heterodimer (USF1/USF2).
CC -!- INTERACTION:
CC Q61069; P42225: Stat1; NbExp=2; IntAct=EBI-2325635, EBI-647118;
CC -!- SUBCELLULAR LOCATION: Nucleus.
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DR EMBL; U41741; AAC52921.1; -; Genomic_DNA.
DR CCDS; CCDS15495.1; -.
DR RefSeq; NP_001292605.1; NM_001305676.1.
DR RefSeq; NP_001292606.1; NM_001305677.1.
DR RefSeq; NP_033506.1; NM_009480.3.
DR AlphaFoldDB; Q61069; -.
DR SMR; Q61069; -.
DR BioGRID; 204464; 5.
DR ComplexPortal; CPX-3085; USF1 upstream stimulatory factor complex.
DR ComplexPortal; CPX-3086; USF1-USF2 upstream stimulatory factor complex.
DR IntAct; Q61069; 1.
DR STRING; 10090.ENSMUSP00000125729; -.
DR iPTMnet; Q61069; -.
DR PhosphoSitePlus; Q61069; -.
DR EPD; Q61069; -.
DR jPOST; Q61069; -.
DR MaxQB; Q61069; -.
DR PaxDb; Q61069; -.
DR PRIDE; Q61069; -.
DR ProteomicsDB; 297901; -.
DR Antibodypedia; 3773; 376 antibodies from 36 providers.
DR DNASU; 22278; -.
DR Ensembl; ENSMUST00000161241; ENSMUSP00000125729; ENSMUSG00000026641.
DR Ensembl; ENSMUST00000167546; ENSMUSP00000128913; ENSMUSG00000026641.
DR GeneID; 22278; -.
DR KEGG; mmu:22278; -.
DR UCSC; uc007doj.2; mouse.
DR CTD; 7391; -.
DR MGI; MGI:99542; Usf1.
DR VEuPathDB; HostDB:ENSMUSG00000026641; -.
DR eggNOG; KOG1318; Eukaryota.
DR GeneTree; ENSGT00940000157083; -.
DR HOGENOM; CLU_070485_0_0_1; -.
DR InParanoid; Q61069; -.
DR OMA; KTIPECN; -.
DR OrthoDB; 1345445at2759; -.
DR PhylomeDB; Q61069; -.
DR TreeFam; TF323338; -.
DR Reactome; R-MMU-9018519; Estrogen-dependent gene expression.
DR BioGRID-ORCS; 22278; 1 hit in 61 CRISPR screens.
DR ChiTaRS; Usf1; mouse.
DR PRO; PR:Q61069; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q61069; protein.
DR Bgee; ENSMUSG00000026641; Expressed in cortical plate and 147 other tissues.
DR ExpressionAtlas; Q61069; baseline and differential.
DR Genevisible; Q61069; MM.
DR GO; GO:0000785; C:chromatin; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0005667; C:transcription regulator complex; ISO:MGI.
DR GO; GO:0043425; F:bHLH transcription factor binding; ISO:MGI.
DR GO; GO:0003677; F:DNA binding; IDA:MGI.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0003690; F:double-stranded DNA binding; ISO:MGI.
DR GO; GO:0019899; F:enzyme binding; ISO:MGI.
DR GO; GO:0042826; F:histone deacetylase binding; ISO:MGI.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0046982; F:protein heterodimerization activity; ISO:MGI.
DR GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
DR GO; GO:0019901; F:protein kinase binding; ISO:MGI.
DR GO; GO:0044877; F:protein-containing complex binding; ISO:MGI.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISO:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0032869; P:cellular response to insulin stimulus; ISO:MGI.
DR GO; GO:0006006; P:glucose metabolic process; ISO:MGI.
DR GO; GO:0019086; P:late viral transcription; ISO:MGI.
DR GO; GO:0055088; P:lipid homeostasis; IMP:BHF-UCL.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0000432; P:positive regulation of transcription from RNA polymerase II promoter by glucose; IMP:BHF-UCL.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISO:MGI.
DR GO; GO:0001666; P:response to hypoxia; ISO:MGI.
DR GO; GO:0009411; P:response to UV; IMP:BHF-UCL.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Isopeptide bond; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Ubl conjugation.
FT CHAIN 1..310
FT /note="Upstream stimulatory factor 1"
FT /id="PRO_0000127497"
FT DOMAIN 199..254
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 171..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..292
FT /note="Leucine-zipper"
FT COMPBIAS 190..209
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 306
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P22415"
SQ SEQUENCE 310 AA; 33570 MW; 7D0AF808A2FDFA1C CRC64;
MKGQQKTAET EEGTVQIQEG AVATGEDPTS VAIASIQSAA TFPDPNVKYV FRTENGGQVM
YRVIQVSEGQ LDGQTEGSGA ISGYPATQSM TQAVIQGAFT SDDAVDTEGA AAETHYTYFP
STAVGDGSGG TTSGSTTAVV TTQGSEALLG QATPPSTGQF FVMMSPQEVL QGGSQRSIAP
RTHPYSPKSE APRTTRDEKR RAQHNEVERR RRDKINNWIV QLSKIIPDCS MESTKSGQSK
GGILSKACDY IQELRQSNHR LSEELQGLDQ LQLDNDVLRQ QVEDLKNKNL LLRAQLRHHG
LEVVIKNDSN
