USF3_HUMAN
ID USF3_HUMAN Reviewed; 2245 AA.
AC Q68DE3; Q7Z3L9; Q8IVF3; Q9H8T4;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 08-MAY-2019, sequence version 4.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Basic helix-loop-helix domain-containing protein USF3 {ECO:0000305};
DE AltName: Full=Upstream transcription factor 3;
GN Name=USF3 {ECO:0000312|HGNC:HGNC:30494}; Synonyms=KIAA2018;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 26-2245, AND VARIANT ALA-222.
RC TISSUE=Retina;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 560-2245.
RC TISSUE=Brain;
RA Nagase T., Kikuno R., Ohara O.;
RT "The nucleotide sequence of a long cDNA clone isolated from human.";
RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1766-2085.
RC TISSUE=Ovary;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP FUNCTION, VARIANTS 1470-GLN--GLN-1472 DEL AND GLN-1472 DEL, AND
RP CHARACTERIZATION OF VARIANTS 1470-GLN--GLN-1472 DEL AND GLN-1472 DEL.
RX PubMed=28011713; DOI=10.1093/hmg/ddw382;
RA Ni Y., Seballos S., Fletcher B., Romigh T., Yehia L., Mester J., Senter L.,
RA Niazi F., Saji M., Ringel M.D., LaFramboise T., Eng C.;
RT "Germline compound heterozygous poly-glutamine deletion in USF3 may be
RT involved in predisposition to heritable and sporadic epithelial thyroid
RT carcinoma.";
RL Hum. Mol. Genet. 26:243-257(2017).
CC -!- FUNCTION: Involved in the negative regulation of epithelial-mesenchymal
CC transition, the process by which epithelial cells lose their polarity
CC and adhesion properties to become mesenchymal cells with enhanced
CC migration and invasive properties. {ECO:0000269|PubMed:28011713}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB14518.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305};
CC Sequence=CAH18277.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC055740; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX537728; CAD97821.1; -; mRNA.
DR EMBL; CR749439; CAH18277.1; ALT_INIT; mRNA.
DR EMBL; AB095938; BAC23114.1; -; mRNA.
DR EMBL; AK023308; BAB14518.1; ALT_SEQ; mRNA.
DR CCDS; CCDS43133.1; -.
DR RefSeq; NP_001009899.3; NM_001009899.3.
DR RefSeq; XP_016861360.1; XM_017005871.1.
DR AlphaFoldDB; Q68DE3; -.
DR SMR; Q68DE3; -.
DR IntAct; Q68DE3; 16.
DR STRING; 9606.ENSP00000320794; -.
DR CAZy; GH47; Glycoside Hydrolase Family 47.
DR GlyGen; Q68DE3; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q68DE3; -.
DR PhosphoSitePlus; Q68DE3; -.
DR BioMuta; USF3; -.
DR DMDM; 298286912; -.
DR jPOST; Q68DE3; -.
DR MassIVE; Q68DE3; -.
DR PaxDb; Q68DE3; -.
DR PeptideAtlas; Q68DE3; -.
DR PRIDE; Q68DE3; -.
DR ProteomicsDB; 66078; -.
DR Antibodypedia; 32593; 21 antibodies from 8 providers.
DR DNASU; 205717; -.
DR Ensembl; ENST00000316407.9; ENSP00000320794.4; ENSG00000176542.10.
DR Ensembl; ENST00000478658.1; ENSP00000420721.1; ENSG00000176542.10.
DR GeneID; 205717; -.
DR KEGG; hsa:205717; -.
DR MANE-Select; ENST00000316407.9; ENSP00000320794.4; NM_001009899.4; NP_001009899.3.
DR UCSC; uc003eam.4; human.
DR CTD; 205717; -.
DR DisGeNET; 205717; -.
DR GeneCards; USF3; -.
DR HGNC; HGNC:30494; USF3.
DR HPA; ENSG00000176542; Low tissue specificity.
DR MalaCards; USF3; -.
DR MIM; 617568; gene.
DR neXtProt; NX_Q68DE3; -.
DR OpenTargets; ENSG00000176542; -.
DR Orphanet; 201; Cowden syndrome.
DR PharmGKB; PA142671594; -.
DR VEuPathDB; HostDB:ENSG00000176542; -.
DR eggNOG; ENOG502QVK9; Eukaryota.
DR GeneTree; ENSGT00390000015759; -.
DR HOGENOM; CLU_001249_0_0_1; -.
DR InParanoid; Q68DE3; -.
DR OMA; CPPTHES; -.
DR PhylomeDB; Q68DE3; -.
DR TreeFam; TF332661; -.
DR PathwayCommons; Q68DE3; -.
DR SignaLink; Q68DE3; -.
DR ChiTaRS; USF3; human.
DR Pharos; Q68DE3; Tdark.
DR PRO; PR:Q68DE3; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q68DE3; protein.
DR Bgee; ENSG00000176542; Expressed in kidney epithelium and 190 other tissues.
DR ExpressionAtlas; Q68DE3; baseline and differential.
DR Genevisible; Q68DE3; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:ARUK-UCL.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:ARUK-UCL.
DR GO; GO:0010719; P:negative regulation of epithelial to mesenchymal transition; IMP:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:ARUK-UCL.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW Coiled coil; DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..2245
FT /note="Basic helix-loop-helix domain-containing protein
FT USF3"
FT /id="PRO_0000295754"
FT DOMAIN 18..69
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 447..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 881..900
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 906..933
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1015..1041
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1164..1238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1307..1331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1460..1624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1636..1664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1736..1764
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1777..1815
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1834..1859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1891..2031
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 77..112
FT /evidence="ECO:0000255"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..287
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 910..928
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1181..1204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1216..1238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1460..1483
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1497..1543
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1554..1624
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1636..1654
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1795..1815
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1834..1858
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1891..1938
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1962..2011
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 222
FT /note="P -> A (in dbSNP:rs9866806)"
FT /evidence="ECO:0000269|PubMed:17974005"
FT /id="VAR_033363"
FT VARIANT 907
FT /note="A -> E (in dbSNP:rs9852318)"
FT /id="VAR_055949"
FT VARIANT 943
FT /note="V -> G (in dbSNP:rs6770105)"
FT /id="VAR_055950"
FT VARIANT 1470..1472
FT /note="Missing (rare variant; may be a risk factor for
FT epithelial thyroid carcinoma; results in increased
FT epithelial-mesenchimal transition when coexpressed with Q-
FT 1472 del)"
FT /evidence="ECO:0000269|PubMed:28011713"
FT /id="VAR_080041"
FT VARIANT 1472
FT /note="Missing (rare variant; may be a risk factor for
FT epithelial thyroid carcinoma; results in increased
FT epithelial-mesenchimal transition when coexpressed with
FT 1470-Q--Q-1472 del)"
FT /evidence="ECO:0000269|PubMed:28011713"
FT /id="VAR_080042"
FT VARIANT 1966
FT /note="A -> V (in dbSNP:rs2290477)"
FT /id="VAR_033364"
FT VARIANT 2200
FT /note="A -> V (in dbSNP:rs930818)"
FT /id="VAR_063263"
FT CONFLICT 328
FT /note="R -> G (in Ref. 2; CAH18277)"
FT /evidence="ECO:0000305"
FT CONFLICT 862
FT /note="S -> P (in Ref. 2; CAH18277)"
FT /evidence="ECO:0000305"
FT CONFLICT 1462..1464
FT /note="Missing (in Ref. 2; CAH18277)"
FT /evidence="ECO:0000305"
FT CONFLICT 1462
FT /note="Missing (in Ref. 3; BAC23114)"
FT /evidence="ECO:0000305"
FT CONFLICT 1953
FT /note="H -> R (in Ref. 2; CAD97821)"
FT /evidence="ECO:0000305"
FT CONFLICT 2015
FT /note="P -> S (in Ref. 4; BAB14518)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2245 AA; 241653 MW; F12A5B5FF05DCA3A CRC64;
MPEMTENETP TKKQHRKKNR ETHNAVERHR KKKINAGINR IGELIPCSPA LKQSKNMILD
QAFKYITELK RQNDELLLNG GNNEQAEEIK KLRKQLEEIQ KENGRYIELL KANDICLYDD
PTIHWKGNLK NSKVSVVIPS DQVQKKIIVY SNGNQPGGNS QGTAVQGITF NVSHNLQKQT
ANVVPVQRTC NLVTPVSISG VYPSENKPWH QTTVPALATN QPVPLCLPAA ISAQSILELP
TSESESNVLG ATSGSLIAVS IESEPHQHHS LHTCLNDQNS SENKNGQENP KVLKKMTPCV
TNIPHSSSAT ATKVHHGNKS CLSIQDFRGD FQNTFVVSVT TTVCSQPPRT AGDSSPMSIS
KSADLTSTAT VVASSAPGVG KATIPISTLS GNPLDNGWTL SCSLPSSSVS TSDLKNINSL
TRISSAGNTQ TTWTTLQLAG NTIQPLSQTP SSAVTPVLNE SGTSPTTSNH SRYVATDINL
NNSFPADGQP VEQVVVTLPS CPSLPMQPLI AQPQVKSQPP KNILPLNSAM QVIQMAQPVG
SAVNSAPTNQ NVIILQPPST TPCPTVMRAE VSNQTVGQQI VIIQAANQNP LPLLPAPPPG
SVRLPINGAN TVIGSNNSVQ NVPTPQTFGG KHLVHILPRP SSLSASNSTQ TFSVTMSNQQ
PQTISLNGQL FALQPVMSSS GTTNQTPMQI IQPTTSEDPN TNVALNTFGA LASLNQSISQ
MAGQSCVQLS ISQPANSQTA ANSQTTTANC VSLTTTAAPP VTTDSSATLA STYNLVSTSS
MNTVACLPNM KSKRLNKKPG GRKHLAANKS ACPLNSVRDV SKLDCPNTEG SAEPPCNDGL
LESFPAVLPS VSVSQANSVS VSASHSLGVL SSESLIPESV SKSKSAEKSS PPSQESVTSE
HFAMAAAKSK DSTPNLQQET SQDKPPSSLA LSDAAKPCAS ANVLIPSPSD PHILVSQVPG
LSSTTSTTST DCVSEVEIIA EPCRVEQDSS DTMQTTGLLK GQGLTTLLSD LAKKKNPQKS
SLSDQMDHPD FSSENPKIVD SSVNLHPKQE LLLMNNDDRD PPQHHSCLPD QEVINGSLIN
GRQADSPMST SSGSSRSFSV ASMLPETTRE DVTSNATTNT CDSCTFVEQT DIVALAARAI
FDQENLEKGR VGLQADIREV ASKPSEASLL EGDPPFKSQI PKESGTGQAE ATPNEFNSQG
SIEATMERPL EKPSCSLGIK TSNASLQDST SQPPSITSLS VNNLIHQSSI SHPLASCAGL
SPTSEQTTVP ATVNLTVSSS SYGSQPPGPS LMTEYSQEQL NTMTSTIPNS QIQEPLLKPS
HESRKDSAKR AVQDDLLLSS AKRQKHCQPA PLRLESMSLM SRTPDTISDQ TQMMVSQIPP
NSSNSVVPVS NPAHGDGLTR LFPPSNNFVT PALRQTEVQC GSQPSVAEQQ QTQASQHLQA
LQQHVPAQGV SHLHSNHLYI KQQQQQQQQQ QQQQQQQQAG QLRERHHLYQ MQHHVPHAES
SVHSQPHNVH QQRTLQQEVQ MQKKRNLVQG TQTSQLSLQP KHHGTDQSRS KTGQPHPHHQ
QMQQQMQQHF GSSQTEKSCE NPSTSRNHHN HPQNHLNQDI MHQQQDVGSR QQGSGVSSEH
VSGHNPMQRL LTSRGLEQQM VSQPSIVTRS SDMTCTPHRP ERNRVSSYSA EALIGKTSSN
SEQRMGISIQ GSRVSDQLEM RSYLDVPRNK SLAIHNMQGR VDHTVASDIR LSDCQTFKPS
GASQQPQSNF EVQSSRNNEI GNPVSSLRSM QSQAFRISQN TGPPPIDRQK RLSYPPVQSI
PTGNGIPSRD SENTCHQSFM QSLLAPHLSD QVIGSQRSLS EHQRNTQCGP SSAIEYNCPP
THENVHIRRE SESQNRESCD MSLGAINTRN STLNIPFSSS SSSGDIQGRN TSPNVSVQKS
NPMRITESHA TKGHMNPPVT TNMHGVARPA LPHPSVSHGN GDQGPAVRQA NSSVPQRSRH
PLQDSSGSKI RQPERNRSGN QRQSTVFDPS LPHLPLSTGG SMILGRQQPA TEKRGSIVRF
MPDSPQVPND NSGPDQHTLS QNFGFSFIPE GGMNPPINAN ASFIPQVTQP SATRTPALIP
VDPQNTLPSF YPPYSPAHPT LSNDISIPYF PNQMFSNPST EKVNSGSLNN RFGSILSPPR
PVGFAQPSFP LLPDMPPMHM TNSHLSNFNM TSLFPEIATA LPDGSAMSPL LTIANSSASD
SSKQSSNRPA HNISHILGHD CSSAV
