USG_ECOLI
ID USG_ECOLI Reviewed; 337 AA.
AC P08390;
DT 01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1988, sequence version 1.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=USG-1 protein;
GN Name=usg; OrderedLocusNames=b2319, JW2316;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=2991861; DOI=10.1093/nar/13.14.5297;
RA Arps P.J., Marvel C.C., Rubin B.C., Tolan D.A., Penhoet E.E., Winkler M.E.;
RT "Structural features of the hisT operon of Escherichia coli K-12.";
RL Nucleic Acids Res. 13:5297-5315(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9205837; DOI=10.1093/dnares/4.2.91;
RA Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T.,
RA Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K.,
RA Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T., Oyama S.,
RA Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H.,
RA Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.;
RT "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12
RT genome corresponding to 50.0-68.8 min on the linkage map and analysis of
RT its sequence features.";
RL DNA Res. 4:91-113(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-13 AND 329-337.
RC STRAIN=K12;
RX PubMed=3029016; DOI=10.1128/jb.169.3.1061-1070.1987;
RA Arps P.J., Winkler M.E.;
RT "Structural analysis of the Escherichia coli K-12 hisT operon by using a
RT kanamycin resistance cassette.";
RL J. Bacteriol. 169:1061-1070(1987).
RN [6]
RP PROTEIN SEQUENCE OF 1-27.
RC STRAIN=K12;
RX PubMed=2681152; DOI=10.1128/jb.171.11.6084-6092.1989;
RA Schoenlein P.V., Roa B.B., Winkler M.E.;
RT "Divergent transcription of pdxB and homology between the pdxB and serA
RT gene products in Escherichia coli K-12.";
RL J. Bacteriol. 171:6084-6092(1989).
CC -!- INTERACTION:
CC P08390; P0A6K3: def; NbExp=3; IntAct=EBI-548921, EBI-548913;
CC P08390; P21599: pykA; NbExp=3; IntAct=EBI-548921, EBI-368956;
CC -!- SIMILARITY: Belongs to the aspartate-semialdehyde dehydrogenase family.
CC {ECO:0000305}.
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DR EMBL; X02743; CAA26521.1; -; Genomic_DNA.
DR EMBL; U00096; AAC75379.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA16176.1; -; Genomic_DNA.
DR EMBL; M15541; AAA24311.1; -; Genomic_DNA.
DR EMBL; M15542; AAA24312.1; -; Genomic_DNA.
DR EMBL; M29962; AAA24309.1; -; Genomic_DNA.
DR PIR; A23792; QQECH3.
DR RefSeq; NP_416822.1; NC_000913.3.
DR RefSeq; WP_001289167.1; NZ_LN832404.1.
DR AlphaFoldDB; P08390; -.
DR SMR; P08390; -.
DR BioGRID; 4262073; 35.
DR BioGRID; 851138; 3.
DR DIP; DIP-11095N; -.
DR IntAct; P08390; 18.
DR STRING; 511145.b2319; -.
DR jPOST; P08390; -.
DR PaxDb; P08390; -.
DR PRIDE; P08390; -.
DR EnsemblBacteria; AAC75379; AAC75379; b2319.
DR EnsemblBacteria; BAA16176; BAA16176; BAA16176.
DR GeneID; 946797; -.
DR KEGG; ecj:JW2316; -.
DR KEGG; eco:b2319; -.
DR PATRIC; fig|1411691.4.peg.4415; -.
DR EchoBASE; EB1052; -.
DR eggNOG; COG0136; Bacteria.
DR HOGENOM; CLU_049966_0_1_6; -.
DR InParanoid; P08390; -.
DR OMA; CEEEMKM; -.
DR PhylomeDB; P08390; -.
DR BioCyc; EcoCyc:EG11059-MON; -.
DR PRO; PR:P08390; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005829; C:cytosol; IDA:EcoCyc.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0008652; P:cellular amino acid biosynthetic process; IEA:InterPro.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR000534; Semialdehyde_DH_NAD-bd.
DR InterPro; IPR012280; Semialdhyde_DH_dimer_dom.
DR Pfam; PF01118; Semialdhyde_dh; 1.
DR Pfam; PF02774; Semialdhyde_dhC; 1.
DR SMART; SM00859; Semialdhyde_dh; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Reference proteome.
FT CHAIN 1..337
FT /note="USG-1 protein"
FT /id="PRO_0000141402"
SQ SEQUENCE 337 AA; 36364 MW; DF399045C50AE3C5 CRC64;
MSEGWNIAVL GATGAVGEAL LETLAERQFP VGEIYALARN ESAGEQLRFG GKTITVQDAA
EFDWTQAQLA FFVAGKEATA AWVEEATNSG CLVIDSSGLF ALEPDVPLVV PEVNPFVLTD
YRNRNVIAVP DSLTSQLLAA LKPLIDQGGL SRISVTSLIS ASAQGKKAVD ALAGQSAKLL
NGIPIDEEDF FGRQLAFNML PLLPDSEGSV REERRIVDEV RKILQDEGLM ISASVVQAPV
FYGHAQMVNF EALRPLAAEE ARDAFVQGED IVLSEENEFP TQVGDASGTP HLSVGCVRND
YGMPEQVQFW SVADNVRFGG ALMAVKIAEK LVQEYLY
