ID   USOM3_ACRMI             Reviewed;         433 AA.
AC   B8RJM0;
DT   09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT   09-JUL-2014, sequence version 1.
DT   25-MAY-2022, entry version 9.
DE   RecName: Full=Uncharacterized skeletal organic matrix protein 3 {ECO:0000303|PubMed:23765379};
DE            Short=Uncharacterized SOMP-3 {ECO:0000303|PubMed:23765379};
DE   Flags: Precursor; Fragment;
OS   Acropora millepora (Staghorn coral) (Heteropora millepora).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia;
OC   Astrocoeniina; Acroporidae; Acropora.
OX   NCBI_TaxID=45264;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=22490231; DOI=10.1111/j.1365-294x.2012.05554.x;
RA   Moya A., Huisman L., Ball E.E., Hayward D.C., Grasso L.C., Chua C.M.,
RA   Woo H.N., Gattuso J.P., Foret S., Miller D.J.;
RT   "Whole transcriptome analysis of the coral Acropora millepora reveals
RT   complex responses to CO(2)-driven acidification during the initiation of
RT   calcification.";
RL   Mol. Ecol. 21:2440-2454(2012).
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 33-46; 82-93 AND 192-202, TISSUE SPECIFICITY, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=23765379; DOI=10.1093/molbev/mst109;
RA   Ramos-Silva P., Kaandorp J., Huisman L., Marie B., Zanella-Cleon I.,
RA   Guichard N., Miller D.J., Marin F.;
RT   "The skeletal proteome of the coral Acropora millepora: the evolution of
RT   calcification by co-option and domain shuffling.";
RL   Mol. Biol. Evol. 30:2099-2112(2013).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC       protein {ECO:0000255}. Note=Presence in the organic matrix of the
CC       skeleton may be due to shedding of a soluble peptide. {ECO:0000255,
CC       ECO:0000303|PubMed:23765379}.
CC   -!- TISSUE SPECIFICITY: Component of the acid-insoluble and acid-soluble
CC       organic matrix of the aragonitic skeleton (at protein level).
CC       {ECO:0000269|PubMed:23765379}.
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DR   EMBL; JR997000; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; B8RJM0; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Membrane; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..>433
FT                   /note="Uncharacterized skeletal organic matrix protein 3"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000429757"
FT   TOPO_DOM        29..274
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        296..433
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          235..266
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          320..340
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          413..433
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        235..252
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        417..433
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         433
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   433 AA;  47159 MW;  3FCD16833FC66240 CRC64;
     MKICGLEKFR VFLSLISMVS LLCNGVNGFT IVRSMAVNGE SVPDRFSNPS CRPSDCALKR
     ASTTNGCSTT RDCCSCQCSK TRATYLTSPF NRCTTSEYID EDCSSFFVLP DDSPPPVADI
     TKPGHINFFS ETRCHKGLRT RSWSHSVDAT SWTTGKPNGF SVELVEGSSS SWKWRLSWQN
     GMDAKFSGLI IKLEFSCQNT RSGCFLMKSK GNYTIPNSEQ WPSIIPTDVS FNLTGENANP
     TANSGTSARS NRNEQNKMEE PARNQAELEP KKTGVVVAGV TVSLAAGFVL ALATLLLMKK
     KQTSLAVNAK ARPNSYLGYE EPVDSAGRPE QTATESPSFD NEFYTTDCVL SLSGNNVGGK
     VTRMGPLPPL PGEESIYAEP MIKRSVAYQG LAEKNKQQDA GTACNVQPQP ECKVIEKTSN
     ENSHDKGTDE DKG