USPA2_COXBU
ID USPA2_COXBU Reviewed; 146 AA.
AC P45680;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Universal stress protein A homolog 2;
GN Name=uspA2; Synonyms=uspA; OrderedLocusNames=CBU_1916;
OS Coxiella burnetii (strain RSA 493 / Nine Mile phase I).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales; Coxiellaceae;
OC Coxiella.
OX NCBI_TaxID=227377;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Nine Mile phase I / Bratislava;
RX PubMed=8071197; DOI=10.1128/jb.176.17.5233-5243.1994;
RA Suhan M., Chen S.Y., Thompson H.A., Hoover T.A., Hill A., Williams J.C.;
RT "Cloning and characterization of an autonomous replication sequence from
RT Coxiella burnetii.";
RL J. Bacteriol. 176:5233-5243(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RSA 493 / Nine Mile phase I;
RX PubMed=12704232; DOI=10.1073/pnas.0931379100;
RA Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C.,
RA Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T.,
RA Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M.,
RA Lee K.H., Carty H.A., Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E.,
RA Fraser C.M., Heidelberg J.F.;
RT "Complete genome sequence of the Q-fever pathogen, Coxiella burnetii.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND DEVELOPMENTAL STAGE.
RC STRAIN=Nine Mile Crazy / RSA 514;
RX PubMed=17088354; DOI=10.1128/iai.00883-06;
RA Coleman S.A., Fischer E.R., Cockrell D.C., Voth D.E., Howe D., Mead D.J.,
RA Samuel J.E., Heinzen R.A.;
RT "Proteome and antigen profiling of Coxiella burnetii developmental forms.";
RL Infect. Immun. 75:290-298(2007).
CC -!- FUNCTION: Involved in stress response. {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: More than twofold more abundant in the large cell
CC variant (LCV) stage than in the small cell variant (SCV) stage (at
CC protein level). LCVs are more metabolically active than SCVs.
CC {ECO:0000269|PubMed:17088354}.
CC -!- SIMILARITY: Belongs to the universal stress protein A family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U10529; AAA56915.1; -; Genomic_DNA.
DR EMBL; AE016828; AAO91407.1; -; Genomic_DNA.
DR PIR; I40650; I40650.
DR RefSeq; NP_820893.1; NC_002971.3.
DR RefSeq; WP_010958534.1; NC_002971.4.
DR AlphaFoldDB; P45680; -.
DR SMR; P45680; -.
DR STRING; 227377.CBU_1916; -.
DR EnsemblBacteria; AAO91407; AAO91407; CBU_1916.
DR GeneID; 1209829; -.
DR KEGG; cbu:CBU_1916; -.
DR PATRIC; fig|227377.7.peg.1900; -.
DR eggNOG; COG0589; Bacteria.
DR HOGENOM; CLU_049301_11_3_6; -.
DR OMA; GAHCDVL; -.
DR Proteomes; UP000002671; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.50.620; -; 1.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR006015; Universal_stress_UspA.
DR InterPro; IPR006016; UspA.
DR Pfam; PF00582; Usp; 1.
DR PIRSF; PIRSF006276; UspA; 1.
DR PRINTS; PR01438; UNVRSLSTRESS.
PE 1: Evidence at protein level;
KW Cytoplasm; Reference proteome.
FT CHAIN 1..146
FT /note="Universal stress protein A homolog 2"
FT /id="PRO_0000147443"
SQ SEQUENCE 146 AA; 15779 MW; 659B31870B8CF4D4 CRC64;
MDNYKKILVA LALDPNSDRP LVEKAKELSA NRDAQLYLIH AVEHLSSYGA AYGVAAGVDV
EDMLLEEAKK RMNEIASQLN ISSDHQIVKV GPAKFLILEQ AKNWGVDLII VGSHGRHGIQ
LLLGSTSNAV LHGAKCDVLA VRIKGS