USPAL_ARATH
ID USPAL_ARATH Reviewed; 175 AA.
AC Q8LGG8; Q940U0; Q9SSA2;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Universal stress protein A-like protein;
GN OrderedLocusNames=At3g01520; ORFNames=F4P13.7;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP X-RAY CRYSTALLOGRAPHY (2.46 ANGSTROMS) OF 2-175 IN COMPLEX WITH AMP.
RG Center for eukaryotic structural genomics (CESG);
RT "Crystal structure of an universal stress protein family protein from
RT Arabidopsis thaliana At3g01520 with AMP bound.";
RL Submitted (JUN-2005) to the PDB data bank.
CC -!- SUBUNIT: Homohexamer. {ECO:0000269|Ref.5}.
CC -!- SIMILARITY: Belongs to the universal stress protein A family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF01537.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAM60866.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AC009325; AAF01537.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE73681.1; -; Genomic_DNA.
DR EMBL; AY052696; AAK96600.1; -; mRNA.
DR EMBL; AF446878; AAL38611.1; -; mRNA.
DR EMBL; AY084275; AAM60866.1; ALT_INIT; mRNA.
DR RefSeq; NP_566140.1; NM_111018.3.
DR PDB; 2GM3; X-ray; 2.46 A; A/B/C/D/E/F=2-175.
DR PDBsum; 2GM3; -.
DR AlphaFoldDB; Q8LGG8; -.
DR SMR; Q8LGG8; -.
DR STRING; 3702.AT3G01520.1; -.
DR PaxDb; Q8LGG8; -.
DR PRIDE; Q8LGG8; -.
DR ProteomicsDB; 228604; -.
DR DNASU; 821122; -.
DR EnsemblPlants; AT3G01520.1; AT3G01520.1; AT3G01520.
DR GeneID; 821122; -.
DR Gramene; AT3G01520.1; AT3G01520.1; AT3G01520.
DR KEGG; ath:AT3G01520; -.
DR Araport; AT3G01520; -.
DR TAIR; locus:2084153; AT3G01520.
DR eggNOG; ENOG502QUI8; Eukaryota.
DR HOGENOM; CLU_049301_9_3_1; -.
DR InParanoid; Q8LGG8; -.
DR OMA; HPSISCK; -.
DR OrthoDB; 1160716at2759; -.
DR PhylomeDB; Q8LGG8; -.
DR EvolutionaryTrace; Q8LGG8; -.
DR PRO; PR:Q8LGG8; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q8LGG8; baseline and differential.
DR Genevisible; Q8LGG8; AT.
DR GO; GO:0005829; C:cytosol; HDA:TAIR.
DR GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR GO; GO:0016208; F:AMP binding; IPI:TAIR.
DR Gene3D; 3.40.50.620; -; 1.
DR InterPro; IPR044187; At3g01520-like_plant.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR006015; Universal_stress_UspA.
DR InterPro; IPR006016; UspA.
DR PANTHER; PTHR47710; PTHR47710; 1.
DR Pfam; PF00582; Usp; 1.
DR PRINTS; PR01438; UNVRSLSTRESS.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome.
FT CHAIN 1..175
FT /note="Universal stress protein A-like protein"
FT /id="PRO_0000250644"
FT BINDING 11
FT /ligand="AMP"
FT /ligand_id="ChEBI:CHEBI:456215"
FT /evidence="ECO:0000269|Ref.5"
FT BINDING 12
FT /ligand="AMP"
FT /ligand_id="ChEBI:CHEBI:456215"
FT /evidence="ECO:0000269|Ref.5"
FT BINDING 13
FT /ligand="AMP"
FT /ligand_id="ChEBI:CHEBI:456215"
FT /evidence="ECO:0000269|Ref.5"
FT BINDING 26
FT /ligand="AMP"
FT /ligand_id="ChEBI:CHEBI:456215"
FT /evidence="ECO:0000269|Ref.5"
FT BINDING 27
FT /ligand="AMP"
FT /ligand_id="ChEBI:CHEBI:456215"
FT /evidence="ECO:0000269|Ref.5"
FT BINDING 53
FT /ligand="AMP"
FT /ligand_id="ChEBI:CHEBI:456215"
FT /evidence="ECO:0000269|Ref.5"
FT BINDING 131
FT /ligand="AMP"
FT /ligand_id="ChEBI:CHEBI:456215"
FT /evidence="ECO:0000269|Ref.5"
FT BINDING 133
FT /ligand="AMP"
FT /ligand_id="ChEBI:CHEBI:456215"
FT /evidence="ECO:0000269|Ref.5"
FT BINDING 145
FT /ligand="AMP"
FT /ligand_id="ChEBI:CHEBI:456215"
FT /evidence="ECO:0000269|Ref.5"
FT BINDING 146
FT /ligand="AMP"
FT /ligand_id="ChEBI:CHEBI:456215"
FT /evidence="ECO:0000269|Ref.5"
FT BINDING 147
FT /ligand="AMP"
FT /ligand_id="ChEBI:CHEBI:456215"
FT /evidence="ECO:0000269|Ref.5"
FT STRAND 6..11
FT /evidence="ECO:0007829|PDB:2GM3"
FT STRAND 16..18
FT /evidence="ECO:0007829|PDB:2GM3"
FT HELIX 25..37
FT /evidence="ECO:0007829|PDB:2GM3"
FT TURN 38..41
FT /evidence="ECO:0007829|PDB:2GM3"
FT STRAND 45..54
FT /evidence="ECO:0007829|PDB:2GM3"
FT HELIX 71..77
FT /evidence="ECO:0007829|PDB:2GM3"
FT HELIX 81..99
FT /evidence="ECO:0007829|PDB:2GM3"
FT STRAND 102..110
FT /evidence="ECO:0007829|PDB:2GM3"
FT HELIX 112..123
FT /evidence="ECO:0007829|PDB:2GM3"
FT STRAND 126..132
FT /evidence="ECO:0007829|PDB:2GM3"
FT HELIX 146..153
FT /evidence="ECO:0007829|PDB:2GM3"
FT STRAND 158..162
FT /evidence="ECO:0007829|PDB:2GM3"
FT HELIX 165..167
FT /evidence="ECO:0007829|PDB:2GM3"
SQ SEQUENCE 175 AA; 19568 MW; 0E62E782EF2AD078 CRC64;
MGSEPTKVMV AVNASTIKDY PNPSISCKRA FEWTLEKIVR SNTSDFKILL LHVQVVDEDG
FDDVDSIYAS PEDFRDMRQS NKAKGLHLLE FFVNKCHEIG VGCEAWIKTG DPKDVICQEV
KRVRPDFLVV GSRGLGRFQK VFVGTVSAFC VKHAECPVMT IKRNADETPS DPADD
