ID   USPA_ECO57              Reviewed;         144 AA.
AC   P0AED2; P28242;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Universal stress protein A;
GN   Name=uspA; OrderedLocusNames=Z4895, ECs4367;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=O157:H7 / EHEC;
RX   PubMed=10499297; DOI=10.1046/j.1365-2672.1999.00594.x;
RA   Chen J., Griffiths M.W.;
RT   "Cloning and sequencing of the gene encoding universal stress protein from
RT   Escherichia coli O157:H7 isolated from Jack-in-a-Box outbreak.";
RL   Lett. Appl. Microbiol. 29:103-107(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Required for resistance to DNA-damaging agents.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the universal stress protein A family.
CC       {ECO:0000305}.
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DR   EMBL; AF346731; AAK30574.1; -; Genomic_DNA.
DR   EMBL; AE005174; AAG58627.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB37790.1; -; Genomic_DNA.
DR   PIR; G86020; G86020.
DR   PIR; G91174; G91174.
DR   RefSeq; NP_312394.1; NC_002695.1.
DR   RefSeq; WP_000323571.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0AED2; -.
DR   SMR; P0AED2; -.
DR   STRING; 155864.EDL933_4732; -.
DR   EnsemblBacteria; AAG58627; AAG58627; Z4895.
DR   EnsemblBacteria; BAB37790; BAB37790; ECs_4367.
DR   GeneID; 67417129; -.
DR   GeneID; 915784; -.
DR   KEGG; ece:Z4895; -.
DR   KEGG; ecs:ECs_4367; -.
DR   PATRIC; fig|386585.9.peg.4561; -.
DR   eggNOG; COG0589; Bacteria.
DR   HOGENOM; CLU_049301_18_0_6; -.
DR   OMA; DFWSKIL; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.50.620; -; 1.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR006015; Universal_stress_UspA.
DR   InterPro; IPR006016; UspA.
DR   Pfam; PF00582; Usp; 1.
DR   PIRSF; PIRSF006276; UspA; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Phosphoprotein; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..144
FT                   /note="Universal stress protein A"
FT                   /id="PRO_0000147397"
SQ   SEQUENCE   144 AA;  16066 MW;  EE3BF2141E44D826 CRC64;
     MAYKHILIAV DLSPESKVLV EKAVSMARPY NAKVSLIHVD VNYSDLYTGL IDVNLGDMQK
     RISEETHHAL TELSTNAGYP ITETLSGSGD LGQVLVDAIK KYDMDLVVCG HHQDFWSKLM
     SSARQLINTV HVDMLIVPLR DEEE