USPA_HAEIN
ID USPA_HAEIN Reviewed; 141 AA.
AC P44880;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Universal stress protein A homolog;
GN Name=uspA; OrderedLocusNames=HI_0815;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=11738040; DOI=10.1016/s0969-2126(01)00680-3;
RA Sousa M.C., McKay D.B.;
RT "Structure of the universal stress protein of Haemophilus influenzae.";
RL Structure 9:1135-1141(2001).
CC -!- FUNCTION: Required for resistance to DNA-damaging agents.
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- MISCELLANEOUS: Unlike MJ0577, UspA shows no evidence of ATP binding
CC activity.
CC -!- SIMILARITY: Belongs to the universal stress protein A family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; L42023; AAC22474.1; -; Genomic_DNA.
DR PIR; A64096; A64096.
DR RefSeq; NP_438975.1; NC_000907.1.
DR RefSeq; WP_005648375.1; NC_000907.1.
DR PDB; 1JMV; X-ray; 1.85 A; A/B/C/D=1-141.
DR PDBsum; 1JMV; -.
DR AlphaFoldDB; P44880; -.
DR SMR; P44880; -.
DR STRING; 71421.HI_0815; -.
DR EnsemblBacteria; AAC22474; AAC22474; HI_0815.
DR KEGG; hin:HI_0815; -.
DR PATRIC; fig|71421.8.peg.856; -.
DR eggNOG; COG0589; Bacteria.
DR HOGENOM; CLU_049301_18_0_6; -.
DR OMA; DFWSKIL; -.
DR PhylomeDB; P44880; -.
DR BioCyc; HINF71421:G1GJ1-856-MON; -.
DR EvolutionaryTrace; P44880; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.50.620; -; 1.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR006015; Universal_stress_UspA.
DR InterPro; IPR006016; UspA.
DR Pfam; PF00582; Usp; 1.
DR PIRSF; PIRSF006276; UspA; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Reference proteome.
FT CHAIN 1..141
FT /note="Universal stress protein A homolog"
FT /id="PRO_0000147400"
FT STRAND 3..9
FT /evidence="ECO:0007829|PDB:1JMV"
FT HELIX 15..29
FT /evidence="ECO:0007829|PDB:1JMV"
FT STRAND 32..40
FT /evidence="ECO:0007829|PDB:1JMV"
FT HELIX 43..45
FT /evidence="ECO:0007829|PDB:1JMV"
FT HELIX 52..57
FT /evidence="ECO:0007829|PDB:1JMV"
FT HELIX 64..75
FT /evidence="ECO:0007829|PDB:1JMV"
FT STRAND 76..78
FT /evidence="ECO:0007829|PDB:1JMV"
FT STRAND 83..88
FT /evidence="ECO:0007829|PDB:1JMV"
FT HELIX 90..100
FT /evidence="ECO:0007829|PDB:1JMV"
FT STRAND 105..110
FT /evidence="ECO:0007829|PDB:1JMV"
FT HELIX 115..126
FT /evidence="ECO:0007829|PDB:1JMV"
FT STRAND 131..137
FT /evidence="ECO:0007829|PDB:1JMV"
SQ SEQUENCE 141 AA; 15758 MW; 6B8693E853E3E3ED CRC64;
MYKHILVAVD LSEESPILLK KAVGIAKRHD AKLSIIHVDV NFSDLYTGLI DVNMSSMQDR
ISTETQKALL DLAESVDYPI SEKLSGSGDL GQVLSDAIEQ YDVDLLVTGH HQDFWSKLMS
STRQVMNTIK IDMLVVPLRD E