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USPA_HAEIN
ID   USPA_HAEIN              Reviewed;         141 AA.
AC   P44880;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Universal stress protein A homolog;
GN   Name=uspA; OrderedLocusNames=HI_0815;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=11738040; DOI=10.1016/s0969-2126(01)00680-3;
RA   Sousa M.C., McKay D.B.;
RT   "Structure of the universal stress protein of Haemophilus influenzae.";
RL   Structure 9:1135-1141(2001).
CC   -!- FUNCTION: Required for resistance to DNA-damaging agents.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- MISCELLANEOUS: Unlike MJ0577, UspA shows no evidence of ATP binding
CC       activity.
CC   -!- SIMILARITY: Belongs to the universal stress protein A family.
CC       {ECO:0000305}.
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DR   EMBL; L42023; AAC22474.1; -; Genomic_DNA.
DR   PIR; A64096; A64096.
DR   RefSeq; NP_438975.1; NC_000907.1.
DR   RefSeq; WP_005648375.1; NC_000907.1.
DR   PDB; 1JMV; X-ray; 1.85 A; A/B/C/D=1-141.
DR   PDBsum; 1JMV; -.
DR   AlphaFoldDB; P44880; -.
DR   SMR; P44880; -.
DR   STRING; 71421.HI_0815; -.
DR   EnsemblBacteria; AAC22474; AAC22474; HI_0815.
DR   KEGG; hin:HI_0815; -.
DR   PATRIC; fig|71421.8.peg.856; -.
DR   eggNOG; COG0589; Bacteria.
DR   HOGENOM; CLU_049301_18_0_6; -.
DR   OMA; DFWSKIL; -.
DR   PhylomeDB; P44880; -.
DR   BioCyc; HINF71421:G1GJ1-856-MON; -.
DR   EvolutionaryTrace; P44880; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.50.620; -; 1.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR006015; Universal_stress_UspA.
DR   InterPro; IPR006016; UspA.
DR   Pfam; PF00582; Usp; 1.
DR   PIRSF; PIRSF006276; UspA; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; Reference proteome.
FT   CHAIN           1..141
FT                   /note="Universal stress protein A homolog"
FT                   /id="PRO_0000147400"
FT   STRAND          3..9
FT                   /evidence="ECO:0007829|PDB:1JMV"
FT   HELIX           15..29
FT                   /evidence="ECO:0007829|PDB:1JMV"
FT   STRAND          32..40
FT                   /evidence="ECO:0007829|PDB:1JMV"
FT   HELIX           43..45
FT                   /evidence="ECO:0007829|PDB:1JMV"
FT   HELIX           52..57
FT                   /evidence="ECO:0007829|PDB:1JMV"
FT   HELIX           64..75
FT                   /evidence="ECO:0007829|PDB:1JMV"
FT   STRAND          76..78
FT                   /evidence="ECO:0007829|PDB:1JMV"
FT   STRAND          83..88
FT                   /evidence="ECO:0007829|PDB:1JMV"
FT   HELIX           90..100
FT                   /evidence="ECO:0007829|PDB:1JMV"
FT   STRAND          105..110
FT                   /evidence="ECO:0007829|PDB:1JMV"
FT   HELIX           115..126
FT                   /evidence="ECO:0007829|PDB:1JMV"
FT   STRAND          131..137
FT                   /evidence="ECO:0007829|PDB:1JMV"
SQ   SEQUENCE   141 AA;  15758 MW;  6B8693E853E3E3ED CRC64;
     MYKHILVAVD LSEESPILLK KAVGIAKRHD AKLSIIHVDV NFSDLYTGLI DVNMSSMQDR
     ISTETQKALL DLAESVDYPI SEKLSGSGDL GQVLSDAIEQ YDVDLLVTGH HQDFWSKLMS
     STRQVMNTIK IDMLVVPLRD E
 
 
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