ID   USPA_YERPE              Reviewed;         148 AA.
AC   Q8ZA49; Q0WA47;
DT   14-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Universal stress protein A;
GN   Name=uspA; OrderedLocusNames=YPO3970, y3859, YP_3333;
OS   Yersinia pestis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis;
RX   PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA   Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA   Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA   Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KIM10+ / Biovar Mediaevalis;
RX   PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA   Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA   Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA   Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA   Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT   "Genome sequence of Yersinia pestis KIM.";
RL   J. Bacteriol. 184:4601-4611(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA   Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA   Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
CC   -!- FUNCTION: Required for resistance to DNA-damaging agents.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the universal stress protein A family.
CC       {ECO:0000305}.
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DR   EMBL; AL590842; CAL22551.1; -; Genomic_DNA.
DR   EMBL; AE009952; AAM87404.1; -; Genomic_DNA.
DR   EMBL; AE017042; AAS63498.1; -; Genomic_DNA.
DR   PIR; AD0483; AD0483.
DR   RefSeq; WP_002209528.1; NZ_WUCM01000026.1.
DR   RefSeq; YP_002348841.1; NC_003143.1.
DR   AlphaFoldDB; Q8ZA49; -.
DR   SMR; Q8ZA49; -.
DR   STRING; 214092.YPO3970; -.
DR   PaxDb; Q8ZA49; -.
DR   DNASU; 1148806; -.
DR   EnsemblBacteria; AAM87404; AAM87404; y3859.
DR   EnsemblBacteria; AAS63498; AAS63498; YP_3333.
DR   GeneID; 66843766; -.
DR   KEGG; ype:YPO3970; -.
DR   KEGG; ypk:y3859; -.
DR   KEGG; ypm:YP_3333; -.
DR   PATRIC; fig|214092.21.peg.4501; -.
DR   eggNOG; COG0589; Bacteria.
DR   HOGENOM; CLU_049301_18_0_6; -.
DR   OMA; DFWSKIL; -.
DR   Proteomes; UP000000815; Chromosome.
DR   Proteomes; UP000001019; Chromosome.
DR   Proteomes; UP000002490; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.50.620; -; 1.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR006015; Universal_stress_UspA.
DR   InterPro; IPR006016; UspA.
DR   Pfam; PF00582; Usp; 1.
DR   PIRSF; PIRSF006276; UspA; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..148
FT                   /note="Universal stress protein A"
FT                   /id="PRO_0000147407"
SQ   SEQUENCE   148 AA;  16439 MW;  AD2A4A74A0D7F7C2 CRC64;
     MAYKHILIAV DLSPESKVLV EKAVSMAKPY NAKVSLIHVD VNYSDLYTGL IDVNLGDMQK
     RISEETHNAL TELSQNAGYP VEQTLSGSGD LGQVLVDAIK KYDIDLVLCG HHQDFWSKLM
     SSARQLINTV HVDMLIVPLR DDENGEDD