CADHB_XENLA
ID CADHB_XENLA Reviewed; 884 AA.
AC P33152;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 27-APR-2001, sequence version 3.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Blastomere cadherin;
DE Short=B-cadherin;
DE AltName: Full=XBcad;
DE Flags: Precursor;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7531482; DOI=10.1016/0925-4773(94)90040-x;
RA Mueller H.-A.J., Kuehl M., Finnemann S., Schneider S., van der Poel S.Z.,
RA Hausen P., Wedlich D.;
RT "Xenopus cadherins: the maternal pool comprises distinguishable members of
RT the family.";
RL Mech. Dev. 47:213-223(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 438-884.
RX PubMed=1840622; DOI=10.1016/0925-4773(91)90039-9;
RA Herzberg F., Wildermuth V., Wedlich D.;
RT "Expression of XBcad, a novel cadherin, during oogenesis and early
RT development of Xenopus.";
RL Mech. Dev. 35:33-42(1991).
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They
CC preferentially interact with themselves in a homophilic manner in
CC connecting cells; cadherins may thus contribute to the sorting of
CC heterogeneous cell types.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
CC protein.
CC -!- TISSUE SPECIFICITY: Expressed in pituitary gland, lung and kidney.
CC -!- DEVELOPMENTAL STAGE: During oogenesis and early development.
CC -!- DOMAIN: Three calcium ions are usually bound at the interface of each
CC cadherin domain and rigidify the connections, imparting a strong
CC curvature to the full-length ectodomain. {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA55292.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; X78546; CAA55292.1; ALT_INIT; mRNA.
DR EMBL; X63719; CAA45251.1; -; mRNA.
DR PIR; S43064; S43064.
DR RefSeq; NP_001089045.1; NM_001095576.1.
DR AlphaFoldDB; P33152; -.
DR SMR; P33152; -.
DR BioGRID; 534745; 1.
DR DNASU; 594865; -.
DR GeneID; 594865; -.
DR CTD; 594865; -.
DR Xenbase; XB-GENE-864850; cdh3.L.
DR Proteomes; UP000186698; Genome assembly.
DR Bgee; 594865; Expressed in gastrula and 16 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR Gene3D; 4.10.900.10; -; 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_cytoplasmic-dom.
DR InterPro; IPR014868; Cadherin_pro_dom.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24027; PTHR24027; 1.
DR Pfam; PF00028; Cadherin; 4.
DR Pfam; PF01049; Cadherin_C; 1.
DR Pfam; PF08758; Cadherin_pro; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 4.
DR SMART; SM01055; Cadherin_pro; 1.
DR SUPFAM; SSF49313; SSF49313; 6.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 4.
PE 2: Evidence at transcript level;
KW Calcium; Cell adhesion; Cell membrane; Cleavage on pair of basic residues;
KW Glycoprotein; Membrane; Metal-binding; Reference proteome; Repeat; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT PROPEP 27..157
FT /evidence="ECO:0000255"
FT /id="PRO_0000003727"
FT CHAIN 158..884
FT /note="Blastomere cadherin"
FT /id="PRO_0000003728"
FT TOPO_DOM 158..706
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 707..730
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 731..884
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 158..265
FT /note="Cadherin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 266..378
FT /note="Cadherin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 379..489
FT /note="Cadherin 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 490..595
FT /note="Cadherin 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 596..706
FT /note="Cadherin 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT CARBOHYD 427
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 560
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 683
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 438..440
FT /note="ILT -> NSA (in Ref. 2; CAA45251)"
FT /evidence="ECO:0000305"
FT CONFLICT 677
FT /note="R -> Q (in Ref. 2; CAA45251)"
FT /evidence="ECO:0000305"
FT CONFLICT 787
FT /note="V -> A (in Ref. 2; CAA45251)"
FT /evidence="ECO:0000305"
FT CONFLICT 820
FT /note="D -> N (in Ref. 2; CAA45251)"
FT /evidence="ECO:0000305"
FT CONFLICT 857
FT /note="D -> N (in Ref. 2; CAA45251)"
FT /evidence="ECO:0000305"
FT CONFLICT 863
FT /note="D -> N (in Ref. 2; CAA45251)"
FT /evidence="ECO:0000305"
FT CONFLICT 882
FT /note="Missing (in Ref. 2; CAA45251)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 884 AA; 97980 MW; 9B865D7EE1DCB75B CRC64;
MGGTDKFRYP SVWLCGLLCL LQVVPSINVD VSGCQPGFSS ANYTFSVNRR ELERGRKLGK
VNLVDCTTRK HGLYDVGDSR FRVLPDGTVL VKRHVKLHSK DTRFTISTWD ARGIKHSTNI
SVVNKRHRSG EEARSRSSEL PVLTFPEKHT GLKRKKRDWV IPPIKVSENE RGPFPKRLVQ
IKSNKEKLSK VFYSITGQGA DTPPEGIFRI EKETGWMQVT RPLDREEYEK YVLLSHAVSE
NGASVEEPME ITVTVIDQND NRPKFTQPVF RGSVREGVQP GTKVMSVSAT DDDDSIDSLN
GVIAYSILKQ DPEEPIPNLF TINRETGVIS LIGTGLDREK FPEYTLTVQA ADLDGAGLTA
EGKAVIEITD ANDNAPIFDP KTYTALVPEN EVGFEVQRLS VTDLDMPGTA AWQAVYKIRV
NEGGFFNITT DPESNQGILT TAKGLDFEVR KQYVIQITVE NAVPFSVPLP TSTATVTVTV
EDVNEAPVFV PVVSRVDVSE DLTRGEKIVS LVAQDPDKQQ IQKLSYFIGN DPARWLTINK
DNGIVTGNGN LDRESEYVKN NTYTVIMLVT DDGVPVGTGT GTLILHVLDI NDNGPVPSPR
VFTMCDQNPE PQVLTITDAD IPPNTYPYSV SLSHGSELTW KAELDSKGTS MRLSPTQQLK
KGDYSIYVLL ADAQANRQLT VVNATVCICE GKAIKCQEKL VAGFDLPIIL VILGSILALL
ILSLLLLLFL KRKKVVKEPL LLPEDDTRDN IFYYGEEGGG EEDQDYDLSQ LHRGLDARPD
IMRNDVVPTL MSVPHYRPRP SNPDEIGNFI DENLDAADND PTAPPYDSLL VFDYEGSGSE
AASLSSLNSS NSNNEHDYNY LNDWGPRFRK LADMYGGDDD DDEE
