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USPB_ECOLI
ID   USPB_ECOLI              Reviewed;         111 AA.
AC   P0A8S5; P37632; Q2M7F6;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Universal stress protein B;
GN   Name=uspB; Synonyms=yhiO; OrderedLocusNames=b3494, JW3461;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=8041620; DOI=10.1093/nar/22.13.2576;
RA   Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R.;
RT   "Analysis of the Escherichia coli genome. V. DNA sequence of the region
RT   from 76.0 to 81.5 minutes.";
RL   Nucleic Acids Res. 22:2576-2586(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   CHARACTERIZATION, AND DISRUPTION PHENOTYPE.
RX   PubMed=9829921; DOI=10.1128/jb.180.23.6140-6147.1998;
RA   Farewell A., Kvint K., Nystroem T.;
RT   "uspB, a new sigmaS-regulated gene in Escherichia coli which is required
RT   for stationary-phase resistance to ethanol.";
RL   J. Bacteriol. 180:6140-6147(1998).
RN   [5]
RP   TOPOLOGY [LARGE SCALE ANALYSIS].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=15919996; DOI=10.1126/science.1109730;
RA   Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT   "Global topology analysis of the Escherichia coli inner membrane
RT   proteome.";
RL   Science 308:1321-1323(2005).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC   -!- INDUCTION: By growth arrest in general, by carbon, phosphate, and
CC       nitrogen starvation as well as osmotic shock and oxidative stress.
CC   -!- DISRUPTION PHENOTYPE: Cells are sensitive to exposure to ethanol but
CC       not heat in stationary phase. {ECO:0000269|PubMed:9829921}.
CC   -!- MISCELLANEOUS: Overexpression of uspB causes cell death in stationary
CC       phase.
CC   -!- SIMILARITY: Belongs to the universal stress protein B family.
CC       {ECO:0000305}.
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DR   EMBL; U00039; AAB18470.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC76519.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE77800.1; -; Genomic_DNA.
DR   PIR; S47714; S47714.
DR   RefSeq; NP_417951.1; NC_000913.3.
DR   RefSeq; WP_000626187.1; NZ_STEB01000046.1.
DR   AlphaFoldDB; P0A8S5; -.
DR   BioGRID; 4262095; 14.
DR   STRING; 511145.b3494; -.
DR   TCDB; 9.B.4.1.1; the universal stress protein-b (uspb) family.
DR   PaxDb; P0A8S5; -.
DR   PRIDE; P0A8S5; -.
DR   DNASU; 948008; -.
DR   EnsemblBacteria; AAC76519; AAC76519; b3494.
DR   EnsemblBacteria; BAE77800; BAE77800; BAE77800.
DR   GeneID; 67417128; -.
DR   GeneID; 948008; -.
DR   KEGG; ecj:JW3461; -.
DR   KEGG; eco:b3494; -.
DR   PATRIC; fig|1411691.4.peg.3228; -.
DR   EchoBASE; EB2143; -.
DR   eggNOG; ENOG502ZP3V; Bacteria.
DR   HOGENOM; CLU_151816_0_0_6; -.
DR   OMA; GGFFTAH; -.
DR   PhylomeDB; P0A8S5; -.
DR   BioCyc; EcoCyc:EG12231-MON; -.
DR   PRO; PR:P0A8S5; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR   GO; GO:0045471; P:response to ethanol; IMP:EcoCyc.
DR   HAMAP; MF_01088; UspB; 1.
DR   InterPro; IPR019598; Universal_stress_protein_B.
DR   Pfam; PF10625; UspB; 1.
PE   1: Evidence at protein level;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..111
FT                   /note="Universal stress protein B"
FT                   /id="PRO_0000212040"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        22..89
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        111
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   111 AA;  13027 MW;  BFD3813EDDD9CBFB CRC64;
     MISTVALFWA LCVVCIVNMA RYFSSLRALL VVLRNCDPLL YQYVDGGGFF TSHGQPNKQV
     RLVWYIYAQR YRDHHDDEFI RRCERVRRQF ILTSALCGLV VVSLIALMIW H
 
 
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