USPC_ECOLI
ID USPC_ECOLI Reviewed; 142 AA.
AC P46888;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Universal stress protein C;
GN Name=uspC; Synonyms=yecG; OrderedLocusNames=b1895, JW1884;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12 / EMG2;
RA Estep P., O'Keeffe T., Robison K., Church G.M.;
RL Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9097040; DOI=10.1093/dnares/3.6.379;
RA Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K.,
RA Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T.,
RA Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S., Nakamura Y.,
RA Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y.,
RA Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C., Yamamoto Y.,
RA Horiuchi T.;
RT "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 40.1-50.0 min region on the linkage map.";
RL DNA Res. 3:379-392(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP FUNCTION, GENE NAME, AND TRANSCRIPTIONAL REGULATION.
RC STRAIN=K12 / MC4100 / ATCC 35695 / DSM 6574;
RX PubMed=11849540; DOI=10.1046/j.1365-2958.2002.02720.x;
RA Gustavsson N., Diez A., Nystroem T.;
RT "The universal stress protein paralogues of Escherichia coli are co-
RT ordinately regulated and co-operate in the defence against DNA damage.";
RL Mol. Microbiol. 43:107-117(2002).
CC -!- FUNCTION: Required for resistance to DNA-damaging agents.
CC {ECO:0000269|PubMed:11849540}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- INDUCTION: During growth inhibition caused by the exhaustion of any of
CC a variety of nutrients (carbon, nitrogen, phosphate, sulfate, required
CC amino acid) or by the presence of a variety of toxic agents. Positively
CC regulated by guanosine 3',5'-bisphosphate (ppGpp) and by a RecA/FtsK-
CC dependent regulatory pathway. {ECO:0000269|PubMed:11849540}.
CC -!- SIMILARITY: Belongs to the universal stress protein A family.
CC {ECO:0000305}.
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DR EMBL; U27211; AAA68603.1; -; Genomic_DNA.
DR EMBL; U00096; AAC74965.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA15716.1; -; Genomic_DNA.
DR PIR; G64952; G64952.
DR RefSeq; NP_416409.1; NC_000913.3.
DR RefSeq; WP_000122416.1; NZ_LN832404.1.
DR AlphaFoldDB; P46888; -.
DR SMR; P46888; -.
DR BioGRID; 4259472; 10.
DR BioGRID; 850761; 6.
DR IntAct; P46888; 11.
DR STRING; 511145.b1895; -.
DR jPOST; P46888; -.
DR PaxDb; P46888; -.
DR PRIDE; P46888; -.
DR DNASU; 946404; -.
DR EnsemblBacteria; AAC74965; AAC74965; b1895.
DR EnsemblBacteria; BAA15716; BAA15716; BAA15716.
DR GeneID; 946404; -.
DR KEGG; ecj:JW1884; -.
DR KEGG; eco:b1895; -.
DR PATRIC; fig|1411691.4.peg.354; -.
DR EchoBASE; EB2704; -.
DR eggNOG; COG0589; Bacteria.
DR HOGENOM; CLU_049301_18_1_6; -.
DR InParanoid; P46888; -.
DR OMA; CGNHNQS; -.
DR PhylomeDB; P46888; -.
DR BioCyc; EcoCyc:G7031-MON; -.
DR PRO; PR:P46888; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0060090; F:molecular adaptor activity; IDA:EcoCyc.
DR GO; GO:0009267; P:cellular response to starvation; IEP:EcoCyc.
DR GO; GO:0034644; P:cellular response to UV; IMP:EcoCyc.
DR GO; GO:0009651; P:response to salt stress; IMP:CACAO.
DR Gene3D; 3.40.50.620; -; 1.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR006015; Universal_stress_UspA.
DR InterPro; IPR006016; UspA.
DR Pfam; PF00582; Usp; 1.
DR PIRSF; PIRSF006276; UspA; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Reference proteome.
FT CHAIN 1..142
FT /note="Universal stress protein C"
FT /id="PRO_0000147408"
SQ SEQUENCE 142 AA; 15633 MW; 87DFEE19A8EE58FC CRC64;
MSYSNILVAV AVTPESQQLL AKAVSIARPV KGHISLITLA SDPEMYNQLA APMLEDLRSV
MHEETQSFLD KLIQDAGYPV DKTFIAYGEL SEHILEVCHK HHFDLVICGN HNHSFFSRAS
CSAKRVIASS EVDVLLVPLT GD
