USPD_ECOLI
ID USPD_ECOLI Reviewed; 142 AA.
AC P0AAB8; P32163; Q2M8L9;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Universal stress protein D;
GN Name=uspD; Synonyms=yiiT; OrderedLocusNames=b3923, JW3894;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=8346018; DOI=10.1093/nar/21.15.3391;
RA Plunkett G. III, Burland V., Daniels D.L., Blattner F.R.;
RT "Analysis of the Escherichia coli genome. III. DNA sequence of the region
RT from 87.2 to 89.2 minutes.";
RL Nucleic Acids Res. 21:3391-3398(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP FUNCTION, GENE NAME, AND TRANSCRIPTIONAL REGULATION.
RC STRAIN=K12 / MC4100 / ATCC 35695 / DSM 6574;
RX PubMed=11849540; DOI=10.1046/j.1365-2958.2002.02720.x;
RA Gustavsson N., Diez A., Nystroem T.;
RT "The universal stress protein paralogues of Escherichia coli are co-
RT ordinately regulated and co-operate in the defence against DNA damage.";
RL Mol. Microbiol. 43:107-117(2002).
CC -!- FUNCTION: Required for resistance to DNA-damaging agents.
CC {ECO:0000269|PubMed:11849540}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- INDUCTION: During growth inhibition caused by the exhaustion of any of
CC a variety of nutrients (carbon, nitrogen, phosphate, sulfate, required
CC amino acid) or by the presence of a variety of toxic agents. Positively
CC regulated by guanosine 3',5'-bisphosphate (ppGpp) and by a RecA/FtsK-
CC dependent regulatory pathway. {ECO:0000269|PubMed:11849540}.
CC -!- SIMILARITY: Belongs to the universal stress protein A family.
CC {ECO:0000305}.
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DR EMBL; L19201; AAB03055.1; -; Genomic_DNA.
DR EMBL; U00096; AAC76905.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE77387.1; -; Genomic_DNA.
DR PIR; S40866; S40866.
DR RefSeq; NP_418358.1; NC_000913.3.
DR RefSeq; WP_000323556.1; NZ_STEB01000017.1.
DR AlphaFoldDB; P0AAB8; -.
DR SMR; P0AAB8; -.
DR BioGRID; 4261396; 7.
DR BioGRID; 852712; 5.
DR DIP; DIP-35856N; -.
DR IntAct; P0AAB8; 7.
DR STRING; 511145.b3923; -.
DR jPOST; P0AAB8; -.
DR PaxDb; P0AAB8; -.
DR PRIDE; P0AAB8; -.
DR EnsemblBacteria; AAC76905; AAC76905; b3923.
DR EnsemblBacteria; BAE77387; BAE77387; BAE77387.
DR GeneID; 66672169; -.
DR GeneID; 948415; -.
DR KEGG; ecj:JW3894; -.
DR KEGG; eco:b3923; -.
DR PATRIC; fig|1411691.4.peg.2782; -.
DR EchoBASE; EB1823; -.
DR eggNOG; COG0589; Bacteria.
DR HOGENOM; CLU_049301_18_0_6; -.
DR InParanoid; P0AAB8; -.
DR OMA; RRMINKM; -.
DR PhylomeDB; P0AAB8; -.
DR BioCyc; EcoCyc:EG11877-MON; -.
DR PRO; PR:P0AAB8; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005829; C:cytosol; IDA:EcoCyc.
DR GO; GO:0042594; P:response to starvation; IEP:EcoCyc.
DR GO; GO:0000303; P:response to superoxide; IMP:EcoCyc.
DR GO; GO:0009411; P:response to UV; IMP:EcoCyc.
DR Gene3D; 3.40.50.620; -; 1.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR006015; Universal_stress_UspA.
DR InterPro; IPR006016; UspA.
DR Pfam; PF00582; Usp; 1.
DR PIRSF; PIRSF006276; UspA; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Reference proteome.
FT CHAIN 1..142
FT /note="Universal stress protein D"
FT /id="PRO_0000147413"
SQ SEQUENCE 142 AA; 16293 MW; 0684CAA0EBE1CF6C CRC64;
MAYKHIGVAI SGNEEDALLV NKALELARHN DAHLTLIHID DGLSELYPGI YFPATEDILQ
LLKNKSDNKL YKLTKNIQWP KTKLRIERGE MPETLLEIMQ KEQCDLLVCG HHHSFINRLM
PAYRGMINKM SADLLIVPFI DK
