ID   USPF_ECOLI              Reviewed;         144 AA.
AC   P37903; P76074; P76853;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Universal stress protein F;
GN   Name=uspF; Synonyms=ynaF, yzzL; OrderedLocusNames=b1376, JW1370;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=9097039; DOI=10.1093/dnares/3.6.363;
RA   Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T.,
RA   Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., Makino K.,
RA   Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S.,
RA   Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G.,
RA   Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Takeuchi Y.,
RA   Wada C., Yamamoto Y., Horiuchi T.;
RT   "A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT   the 28.0-40.1 min region on the linkage map.";
RL   DNA Res. 3:363-377(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   PROTEIN SEQUENCE OF 1-12.
RC   STRAIN=K12 / EMG2;
RX   PubMed=9298646; DOI=10.1002/elps.1150180807;
RA   Link A.J., Robison K., Church G.M.;
RT   "Comparing the predicted and observed properties of proteins encoded in the
RT   genome of Escherichia coli K-12.";
RL   Electrophoresis 18:1259-1313(1997).
RN   [5]
RP   PROTEIN SEQUENCE OF 1-11.
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RA   Pasquali C., Sanchez J.-C., Ravier F., Golaz O., Hughes G.J., Frutiger S.,
RA   Paquet N., Wilkins M., Appel R.D., Bairoch A., Hochstrasser D.F.;
RL   Submitted (SEP-1994) to UniProtKB.
RN   [6]
RP   GENE NAME.
RC   STRAIN=K12 / MC4100 / ATCC 35695 / DSM 6574;
RX   PubMed=11849540; DOI=10.1046/j.1365-2958.2002.02720.x;
RA   Gustavsson N., Diez A., Nystroem T.;
RT   "The universal stress protein paralogues of Escherichia coli are co-
RT   ordinately regulated and co-operate in the defence against DNA damage.";
RL   Mol. Microbiol. 43:107-117(2002).
RN   [7]
RP   3D-STRUCTURE MODELING.
RX   PubMed=12381839; DOI=10.1110/ps.0217502;
RA   Saveanu C., Miron S., Borza T., Craescu C.T., Labesse G., Gagyi C.,
RA   Popescu A., Schaeffer F., Namane A., Laurent-Winter C., Barzu O.,
RA   Gilles A.-M.;
RT   "Structural and nucleotide-binding properties of YajQ and YnaF, two
RT   Escherichia coli proteins of unknown function.";
RL   Protein Sci. 11:2551-2560(2002).
CC   -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the universal stress protein A family.
CC       {ECO:0000305}.
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DR   EMBL; U00096; AAC74458.2; -; Genomic_DNA.
DR   EMBL; AP009048; BAA14980.1; -; Genomic_DNA.
DR   PIR; C64888; C64888.
DR   RefSeq; NP_415894.4; NC_000913.3.
DR   RefSeq; WP_001300461.1; NZ_SSZK01000012.1.
DR   AlphaFoldDB; P37903; -.
DR   SMR; P37903; -.
DR   BioGRID; 4262881; 12.
DR   DIP; DIP-12739N; -.
DR   IntAct; P37903; 19.
DR   STRING; 511145.b1376; -.
DR   SWISS-2DPAGE; P37903; -.
DR   jPOST; P37903; -.
DR   PaxDb; P37903; -.
DR   PRIDE; P37903; -.
DR   EnsemblBacteria; AAC74458; AAC74458; b1376.
DR   EnsemblBacteria; BAA14980; BAA14980; BAA14980.
DR   GeneID; 945948; -.
DR   KEGG; ecj:JW1370; -.
DR   KEGG; eco:b1376; -.
DR   PATRIC; fig|1411691.4.peg.897; -.
DR   EchoBASE; EB2539; -.
DR   eggNOG; COG0589; Bacteria.
DR   HOGENOM; CLU_049301_12_0_6; -.
DR   InParanoid; P37903; -.
DR   OMA; KNWRTEK; -.
DR   PhylomeDB; P37903; -.
DR   BioCyc; EcoCyc:G6699-MON; -.
DR   PRO; PR:P37903; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IDA:EcoliWiki.
DR   GO; GO:0007155; P:cell adhesion; IMP:EcoCyc.
DR   GO; GO:0006979; P:response to oxidative stress; IMP:EcoCyc.
DR   Gene3D; 3.40.50.620; -; 1.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR006015; Universal_stress_UspA.
DR   InterPro; IPR006016; UspA.
DR   Pfam; PF00582; Usp; 1.
DR   PRINTS; PR01438; UNVRSLSTRESS.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Reference proteome.
FT   CHAIN           1..144
FT                   /note="Universal stress protein F"
FT                   /id="PRO_0000147426"
SQ   SEQUENCE   144 AA;  16017 MW;  F30D0FC681EBF32D CRC64;
     MNRTILVPID ISDSELTQRV ISHVEEEAKI DDAEVHFLTV IPSLPYYASL GLAYSAELPA
     MDDLKAEAKS QLEEIIKKFK LPTDRVHVHV EEGSPKDRIL ELAKKIPAHM IIIASHRPDI
     TTYLLGSNAA AVVRHAECSV LVVR