ID   USP_BOMMO               Reviewed;         462 AA.
AC   P49700;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=Protein ultraspiracle homolog;
DE   AltName: Full=BmCF1;
DE   AltName: Full=Nuclear receptor subfamily 2 group B member 4;
DE   AltName: Full=RXR type hormone receptor CF1;
GN   Name=USP; Synonyms=Cf1, NR2B4;
OS   Bombyx mori (Silk moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Bombycidae; Bombycinae; Bombyx.
OX   NCBI_TaxID=7091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=703; TISSUE=Ovary;
RX   PubMed=8176738; DOI=10.1006/jmbi.1994.1306;
RA   Tzertzinis G., Malecki A., Kafatos F.C.;
RT   "BmCF1, a Bombyx mori RXR-type receptor related to the Drosophila
RT   ultraspiracle.";
RL   J. Mol. Biol. 238:479-486(1994).
CC   -!- SUBUNIT: Heterodimer of USP and ECR. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Abundant expression seen in males and ovaries.
CC   -!- DEVELOPMENTAL STAGE: It is present in constant amounts throughout
CC       vitellogenesis, decreases between the end of vitellogenesis and the
CC       onset of choriogenesis and increases again during the later stages of
CC       choriogenesis (but levels remain lower than that observed during
CC       vitellogenesis).
CC   -!- DOMAIN: Composed of three domains: a modulating N-terminal domain, a
CC       DNA-binding domain and a C-terminal ligand-binding domain.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR2
CC       subfamily. {ECO:0000305}.
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DR   EMBL; U06073; AAC13750.1; -; mRNA.
DR   PIR; S44490; S44490.
DR   RefSeq; NP_001037470.1; NM_001044005.1.
DR   AlphaFoldDB; P49700; -.
DR   SMR; P49700; -.
DR   DIP; DIP-788N; -.
DR   STRING; 7091.BGIBMGA006183-TA; -.
DR   GeneID; 693034; -.
DR   KEGG; bmor:693034; -.
DR   CTD; 31165; -.
DR   eggNOG; KOG3575; Eukaryota.
DR   HOGENOM; CLU_061578_1_0_1; -.
DR   InParanoid; P49700; -.
DR   OrthoDB; 912470at2759; -.
DR   Proteomes; UP000005204; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0003707; F:nuclear steroid receptor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR000003; Retinoid-X_rcpt/HNF4.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00545; RETINOIDXR.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..462
FT                   /note="Protein ultraspiracle homolog"
FT                   /id="PRO_0000053583"
FT   DOMAIN          204..453
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        114..179
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         114..134
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         150..174
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   REGION          1..113
FT                   /note="Modulating"
FT                   /evidence="ECO:0000250"
FT   REGION          180..201
FT                   /note="Hinge"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   462 AA;  52149 MW;  9939C79C78BB1BE6 CRC64;
     MSSVAKKDKR TMSVTALINR AWPMTPSPQQ QQQMVPSTQH SNFLHAMATP STTPNVELDI
     QWLNIESGFM SPMSPPEMKP DTAMLDGFRD DSTPPPPFKN YPPNHPLSGS KHLCSICGDR
     ASGKHYGVYS CEGCKGFFKR TVRKDLTYAC REDKNCIIDK RQRNRCQYCR YQKCLACGMK
     REAVQEERQR AARRTEDAHP SSSVQELSIE RLLELEALVA DSAEELQILR VGPESGVPAK
     YRAPVSSLCQ IGNKQIAALI VWARDIPHFG QLEIDDQILL IKGSWNELLL FAIAWRSMEF
     LNDERENVDS RNTAPPQLIC LMPGMTLHRN SALQAGVGQI FDRVLSELSL KMRSLRMDQA
     ECVALKAIIL LNPDVKGLKN KQEVDVLREK MFLCLDEYCR RSRGGEEGRF AALLLRLPAL
     RSISLKSFEH LYLFHLVAEG SVSSYIRDAL CNHAPPIDTN IM