ID   USP_ORYSI               Reviewed;         616 AA.
AC   A2YGP6;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 2.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=UDP-sugar pyrophosphorylase;
DE            EC=2.7.7.64;
GN   Name=USP; ORFNames=OsI_023489;
OS   Oryza sativa subsp. indica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39946;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. 93-11;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
CC   -!- FUNCTION: May function as the terminal enzyme of the myo-inositol
CC       oxidation (MIO) pathway. May also play a role in the salvage pathway
CC       for synthesis of nucleotide sugars (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a monosaccharide 1-phosphate + H(+) + UTP = a UDP-
CC         monosaccharide + diphosphate; Xref=Rhea:RHEA:13205,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:46398,
CC         ChEBI:CHEBI:140358, ChEBI:CHEBI:140359; EC=2.7.7.64;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the USP family. {ECO:0000305}.
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DR   EMBL; CM000131; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A2YGP6; -.
DR   SMR; A2YGP6; -.
DR   STRING; 39946.A2YGP6; -.
DR   Proteomes; UP000007015; Chromosome 6.
DR   GO; GO:0051748; F:UTP-monosaccharide-1-phosphate uridylyltransferase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   InterPro; IPR039741; UDP-sugar_pyrophosphorylase.
DR   InterPro; IPR002618; UDPGP_fam.
DR   PANTHER; PTHR11952; PTHR11952; 1.
DR   Pfam; PF01704; UDPGP; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
PE   3: Inferred from homology;
KW   Nucleotidyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..616
FT                   /note="UDP-sugar pyrophosphorylase"
FT                   /id="PRO_0000289981"
SQ   SEQUENCE   616 AA;  67462 MW;  049782AA7575D8B2 CRC64;
     MASDGNGAAA VAALGISGGG GDDWAPPLRR NLPLLAPHEV KLAKLLLSEG QSHLFEHWPE
     PGVDDDKKRN FFDQVCRLNS SYPGGLASYI QNARKLLADS KAGKNPYDGF SPSVPSGEVL
     TFGDDNFVSL EEAGVKEARH AAFVLVAGGL GERLGYKGIK VALPRETTTG KCFLQHYIES
     ILALQEASCK LVEGECNTKI PFVIMTSDDT NALTVKLLES NSYFGMEPSQ VHILKQEKVA
     CLADNDARLA LDPNDKYKIQ TKPHGHGDVH ALLYSSGLLE QWKSTGRKWV LFFQDTNGLL
     FNAIPSALGV SATKGYNVNS LAVPRKAKEA IGGITKLTHV DGRTMVINVE YNQLDPLLRA
     TGHPDGDANC ETGYSPYPGN INQLILEIGP YMEELQKTHG AISEFVNPKY TDSTKTAFKS
     STRLECMMQD YPKTLPPSAK VGFTVMDAWL AYAPVKNNPE DAAKVPKGNP YHSATSGEMA
     IYRANSLILR KAGAQIADPV IDTFNGQEVE VWPRITWIPR WGLIFKDVKA KVHSNSSVSQ
     RSALVINGKN ITIQGLSLDG TLIVNAKDEA KFNVTGHIEN KGWTIQHVDH KDTSEKEEIR
     IRGFKFNKVE QLELNY