ID   USP_ORYSJ               Reviewed;         616 AA.
AC   Q5Z8Y4; A3BF42; B7E9B4;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=UDP-sugar pyrophosphorylase;
DE            EC=2.7.7.64;
GN   Name=USP; OrderedLocusNames=Os06g0701200, LOC_Os06g48760;
GN   ORFNames=OsJ_021664, P0596H10.4;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
CC   -!- FUNCTION: May function as the terminal enzyme of the myo-inositol
CC       oxidation (MIO) pathway. May also play a role in the salvage pathway
CC       for synthesis of nucleotide sugars (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a monosaccharide 1-phosphate + H(+) + UTP = a UDP-
CC         monosaccharide + diphosphate; Xref=Rhea:RHEA:13205,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:46398,
CC         ChEBI:CHEBI:140358, ChEBI:CHEBI:140359; EC=2.7.7.64;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the USP family. {ECO:0000305}.
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DR   EMBL; AP003726; BAD53770.1; -; Genomic_DNA.
DR   EMBL; AP008212; BAF20396.1; -; Genomic_DNA.
DR   EMBL; AP014962; BAS99346.1; -; Genomic_DNA.
DR   EMBL; CM000143; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK064009; BAG88961.1; -; mRNA.
DR   RefSeq; XP_015644365.1; XM_015788879.1.
DR   AlphaFoldDB; Q5Z8Y4; -.
DR   SMR; Q5Z8Y4; -.
DR   STRING; 4530.OS06T0701200-01; -.
DR   PaxDb; Q5Z8Y4; -.
DR   PRIDE; Q5Z8Y4; -.
DR   EnsemblPlants; Os06t0701200-01; Os06t0701200-01; Os06g0701200.
DR   GeneID; 4341967; -.
DR   Gramene; Os06t0701200-01; Os06t0701200-01; Os06g0701200.
DR   KEGG; osa:4341967; -.
DR   eggNOG; KOG2388; Eukaryota.
DR   HOGENOM; CLU_016797_0_0_1; -.
DR   InParanoid; Q5Z8Y4; -.
DR   OMA; PMGPRVV; -.
DR   OrthoDB; 888726at2759; -.
DR   PlantReactome; R-OSA-1119431; UDP-D-glucuronate biosynthesis (from myo-inositol).
DR   PlantReactome; R-OSA-1119574; UDP-L-arabinose biosynthesis and transport.
DR   Proteomes; UP000000763; Chromosome 6.
DR   Proteomes; UP000007752; Chromosome 6.
DR   Proteomes; UP000059680; Chromosome 6.
DR   Genevisible; Q5Z8Y4; OS.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblPlants.
DR   GO; GO:0090406; C:pollen tube; IEA:EnsemblPlants.
DR   GO; GO:0047350; F:glucuronate-1-phosphate uridylyltransferase activity; IEA:EnsemblPlants.
DR   GO; GO:0003977; F:UDP-N-acetylglucosamine diphosphorylase activity; IBA:GO_Central.
DR   GO; GO:0010491; F:UTP:arabinose-1-phosphate uridylyltransferase activity; IEA:EnsemblPlants.
DR   GO; GO:0017103; F:UTP:galactose-1-phosphate uridylyltransferase activity; IEA:EnsemblPlants.
DR   GO; GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase activity; IEA:EnsemblPlants.
DR   GO; GO:0047338; F:UTP:xylose-1-phosphate uridylyltransferase activity; IEA:EnsemblPlants.
DR   GO; GO:0009555; P:pollen development; IEA:EnsemblPlants.
DR   GO; GO:0052573; P:UDP-D-galactose metabolic process; IEA:EnsemblPlants.
DR   GO; GO:0006011; P:UDP-glucose metabolic process; IEA:EnsemblPlants.
DR   GO; GO:0046398; P:UDP-glucuronate metabolic process; IEA:EnsemblPlants.
DR   GO; GO:0033356; P:UDP-L-arabinose metabolic process; IEA:EnsemblPlants.
DR   GO; GO:0006048; P:UDP-N-acetylglucosamine biosynthetic process; IBA:GO_Central.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   InterPro; IPR039741; UDP-sugar_pyrophosphorylase.
DR   InterPro; IPR002618; UDPGP_fam.
DR   PANTHER; PTHR11952; PTHR11952; 1.
DR   Pfam; PF01704; UDPGP; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
PE   2: Evidence at transcript level;
KW   Nucleotidyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..616
FT                   /note="UDP-sugar pyrophosphorylase"
FT                   /id="PRO_0000289982"
SQ   SEQUENCE   616 AA;  67509 MW;  86DB639FAAFE0F10 CRC64;
     MASDGDGAAA VAALGISGGG GDDWAPPLRR NLPLLAPHEV KLAKLLLSEG QSHLFEHWPE
     PGVDDDKKRN FFDQVCRLNS SYPGGLASYI QNARKLLADS KAGKNPYDGF SPSVPSGEVL
     TFGDDNFVSL EEAGVKEARH AAFVLVAGGL GERLGYKGIK VALPRETTTG KCFLQHYIES
     ILALQEASCK LVEGECNTKI PFVIMTSDDT NALTVKLLES NSYFGMEPSQ VHILKQEKVA
     CLADNDARLA LDPNDKYKIQ TKPHGHGDVH ALLYSSGLLE QWKSTGRKWV LFFQDTNGLL
     FNAIPSALGV SATKGYNVNS LAVPRKAKEA IGGITKLTHV DGRTMVINVE YNQLDPLLRA
     TGHPDGDANC ETGYSPYPGN INQLILEIGP YMEELQKTHG AISEFVNPKY TDSTKTAFKS
     STRLECMMQD YPKTLPPSAK VGFTVMDAWL TYAPVKNNPE DSAKVPKGNP YHSATSGEMA
     IYRANSLILR KAGAQIADPV IDTFNGQEVE VWPRITWIPR WGLIFKDVKA KVHSNSSVSQ
     RSALVINGKN ITIQGLSLDG TLIVNAKDEA KFNVTGHIEN KGWTIQHVDH KDTSEKEEIR
     IRGFKFNKVE QLELNY