ID   UTER_BOVIN              Reviewed;          91 AA.
AC   Q2VPS3; A0JNN9;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   10-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Uteroglobin;
DE   AltName: Full=Secretoglobin family 1A member 1;
DE   Flags: Precursor;
GN   Name=SCGB1A1; Synonyms=UGL;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Endometrium;
RA   Decken V., Delbrueck H., Herrler A.;
RT   "Bovine uteroglobin: sequence and crystalization data.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal lung;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds phosphatidylcholine, phosphatidylinositol,
CC       polychlorinated biphenyls (PCB) and weakly progesterone, potent
CC       inhibitor of phospholipase A2. {ECO:0000250}.
CC   -!- SUBUNIT: Antiparallel homodimer; disulfide-linked (By similarity).
CC       Interaction with LMBR1L is controversial (By similarity).
CC       {ECO:0000250|UniProtKB:P11684}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the secretoglobin family. {ECO:0000305}.
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DR   EMBL; AY994053; AAY54276.1; -; mRNA.
DR   EMBL; BC126820; AAI26821.1; -; mRNA.
DR   RefSeq; NP_001070444.2; NM_001076976.3.
DR   AlphaFoldDB; Q2VPS3; -.
DR   SMR; Q2VPS3; -.
DR   STRING; 9913.ENSBTAP00000044005; -.
DR   PaxDb; Q2VPS3; -.
DR   GeneID; 767867; -.
DR   KEGG; bta:767867; -.
DR   CTD; 7356; -.
DR   eggNOG; ENOG502SXFT; Eukaryota.
DR   HOGENOM; CLU_166234_1_0_1; -.
DR   InParanoid; Q2VPS3; -.
DR   OrthoDB; 1608982at2759; -.
DR   TreeFam; TF338407; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0019834; F:phospholipase A2 inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd00633; Secretoglobin; 1.
DR   InterPro; IPR016126; Secretoglobin.
DR   InterPro; IPR043215; Secretoglobin_1C-like.
DR   InterPro; IPR035960; Secretoglobin_sf.
DR   InterPro; IPR000329; Uteroglobin.
DR   PANTHER; PTHR10136; PTHR10136; 1.
DR   Pfam; PF01099; Uteroglobin; 1.
DR   PRINTS; PR00486; UTEROGLOBIN.
DR   SUPFAM; SSF48201; SSF48201; 1.
DR   PROSITE; PS51311; SCGB; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Phospholipase A2 inhibitor; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..91
FT                   /note="Uteroglobin"
FT                   /id="PRO_0000223333"
FT   DISULFID        24
FT                   /note="Interchain (with C-90)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        90
FT                   /note="Interchain (with C-24)"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        81
FT                   /note="M -> L (in Ref. 2; AAI26821)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   91 AA;  9879 MW;  67603E2FA9F0105C CRC64;
     MKLTIAIVLV TLTLFCRPAS TEVCPSLLYV LGNLIAGTPS SFEATLEPFS PDEDMKEATS
     QLKTLVDTLS PKAKDSMLEL MMKIIQSPEC A