ID   UTER_HORSE              Reviewed;          91 AA.
AC   Q8MKG2; Q5EG10;
DT   21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 2.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Uteroglobin;
DE   AltName: Full=Secretoglobin family 1A member 1;
DE   Flags: Precursor;
GN   Name=SCGB1A1; Synonyms=UGB;
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=12021053; DOI=10.1095/biolreprod66.6.1723;
RA   Muller-Schottle F., Bogusz A., Grotzinger J., Herrler A., Krusche C.A.,
RA   Beier-Hellwig K., Beier H.M.;
RT   "Full-length complementary DNA and the derived amino acid sequence of horse
RT   uteroglobin.";
RL   Biol. Reprod. 66:1723-1728(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lung;
RA   Katavolos P., Bayley T., Clark M., Bienzle D.;
RT   "Equine Secretoglobin (SCGB1A1) (CCSP).";
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds phosphatidylcholine, phosphatidylinositol,
CC       polychlorinated biphenyls (PCB) and weakly progesterone, potent
CC       inhibitor of phospholipase A2. {ECO:0000250}.
CC   -!- SUBUNIT: Antiparallel homodimer; disulfide-linked (By similarity).
CC       Interaction with LMBR1L is controversial (By similarity).
CC       {ECO:0000250|UniProtKB:P11684}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Clara cells (nonciliated cells of the surface
CC       epithelium of the pulmonary airways). Expressed in lung, uterus, and
CC       prostate. {ECO:0000269|PubMed:12021053}.
CC   -!- SIMILARITY: Belongs to the secretoglobin family. {ECO:0000305}.
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DR   EMBL; AF372660; AAM21316.1; -; mRNA.
DR   EMBL; AY885564; AAW83220.1; -; mRNA.
DR   RefSeq; NP_001075327.2; NM_001081858.2.
DR   AlphaFoldDB; Q8MKG2; -.
DR   SMR; Q8MKG2; -.
DR   STRING; 9796.ENSECAP00000011652; -.
DR   PaxDb; Q8MKG2; -.
DR   GeneID; 100033916; -.
DR   KEGG; ecb:100033916; -.
DR   CTD; 7356; -.
DR   InParanoid; Q8MKG2; -.
DR   OrthoDB; 1608982at2759; -.
DR   Proteomes; UP000002281; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0019834; F:phospholipase A2 inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd00633; Secretoglobin; 1.
DR   InterPro; IPR016126; Secretoglobin.
DR   InterPro; IPR043215; Secretoglobin_1C-like.
DR   InterPro; IPR035960; Secretoglobin_sf.
DR   InterPro; IPR000329; Uteroglobin.
DR   PANTHER; PTHR10136; PTHR10136; 1.
DR   Pfam; PF01099; Uteroglobin; 1.
DR   PRINTS; PR00486; UTEROGLOBIN.
DR   SUPFAM; SSF48201; SSF48201; 1.
DR   PROSITE; PS51311; SCGB; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Phospholipase A2 inhibitor; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000250"
FT   CHAIN           22..91
FT                   /note="Uteroglobin"
FT                   /id="PRO_0000036364"
FT   DISULFID        24
FT                   /note="Interchain (with C-90)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        90
FT                   /note="Interchain (with C-24)"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        22
FT                   /note="E -> G (in Ref. 1; AAM21316)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        26
FT                   /note="S -> R (in Ref. 1; AAM21316)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        29
FT                   /note="D -> G (in Ref. 1; AAM21316)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        59
FT                   /note="T -> A (in Ref. 1; AAM21316)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   91 AA;  9674 MW;  3465584FB654BA24 CRC64;
     MKLAITITLA ILALCCSPAS AEICQSFADI IQGLFLGTPA SFEAAVEPFK PDADMKAATT
     QLKTLVDFLP KNTKDSILKL MDKIAKSPLC A