UTER_HUMAN
ID UTER_HUMAN Reviewed; 91 AA.
AC P11684; B2R5F2; Q6FHH3; Q9UCM2; Q9UCM4;
DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1989, sequence version 1.
DT 03-AUG-2022, entry version 187.
DE RecName: Full=Uteroglobin;
DE AltName: Full=Clara cell phospholipid-binding protein;
DE Short=CCPBP;
DE AltName: Full=Clara cells 10 kDa secretory protein;
DE Short=CC10;
DE AltName: Full=Secretoglobin family 1A member 1;
DE AltName: Full=Urinary protein 1;
DE Short=UP-1;
DE Short=UP1;
DE Short=Urine protein 1;
DE Flags: Precursor;
GN Name=SCGB1A1; Synonyms=CC10, CCSP, UGB;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Lung;
RX PubMed=3167058; DOI=10.1016/0167-4781(88)90129-7;
RA Singh G., Katyal S.L., Brown W.E., Phillips S., Kennedy A.L., Anthony J.,
RA Squeglia N.;
RT "Amino-acid and cDNA nucleotide sequences of human Clara cell 10 kDa
RT protein.";
RL Biochim. Biophys. Acta 950:329-337(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC TISSUE=Lung;
RX PubMed=7733299; DOI=10.1152/ajplung.1995.268.4.l565;
RA Hay J.G., Danel C., Chu C., Crystal R.G.;
RT "Human CC10 gene expression in airway epithelium and subchromosomal locus
RT suggest linkage to airway disease.";
RL Am. J. Physiol. 268:L565-L575(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-18.
RX PubMed=1284526; DOI=10.1093/hmg/1.6.371;
RA Wolf M., Klug J., Hackenberg R., Gessler M., Grzeschik K.-H., Beato M.,
RA Suske G.;
RT "Human CC10, the homologue of rabbit uteroglobin: genomic cloning,
RT chromosomal localization and expression in endometrial cell lines.";
RL Hum. Mol. Genet. 1:371-378(1992).
RN [8]
RP PROTEIN SEQUENCE OF 22-74.
RC TISSUE=Urine;
RX PubMed=1400743; DOI=10.1016/0378-4347(92)80595-h;
RA Okutani R., Itoh Y., Hirata H., Kasahara T., Mukaida N., Kawai T.;
RT "Simple and high-yield purification of urine protein 1 using immunoaffinity
RT chromatography: evidence for the identity of urine protein 1 and human
RT Clara cell 10-kilodalton protein.";
RL J. Chromatogr. A 577:25-35(1992).
RN [9]
RP PROTEIN SEQUENCE OF 22-45.
RC TISSUE=Urine;
RX PubMed=1395029; DOI=10.1016/0009-8981(92)90122-7;
RA Bernard A., Roels H., Lauwerys R., Witters R., Gielens C., Soumillion A.,
RA van Damme J., de Ley M.;
RT "Human urinary protein 1: evidence for identity with the Clara cell protein
RT and occurrence in respiratory tract and urogenital secretions.";
RL Clin. Chim. Acta 207:239-249(1992).
RN [10]
RP PROTEIN SEQUENCE OF 22-33.
RX PubMed=11788998;
RX DOI=10.1002/1615-9861(200201)2:1<112::aid-prot112>3.0.co;2-n;
RA Ghafouri B., Stahlbom B., Tagesson C., Lindahl M.;
RT "Newly identified proteins in human nasal lavage fluid from non-smokers and
RT smokers using two-dimensional gel electrophoresis and peptide mass
RT fingerprinting.";
RL Proteomics 2:112-120(2002).
RN [11]
RP INTERACTION WITH LMBR1L.
RX PubMed=16423471; DOI=10.1016/j.gene.2005.10.027;
RA Zhang Z., Kim S.J., Chowdhury B., Wang J., Lee Y.C., Tsai P.C., Choi M.,
RA Mukherjee A.B.;
RT "Interaction of uteroglobin with lipocalin-1 receptor suppresses cancer
RT cell motility and invasion.";
RL Gene 369:66-71(2006).
RN [12]
RP ABSENCE OF INTERACTION WITH LMBR1L.
RX PubMed=23964685; DOI=10.3109/09687688.2013.823018;
RA Hesselink R.W., Findlay J.B.;
RT "Expression, characterization and ligand specificity of lipocalin-1
RT interacting membrane receptor (LIMR).";
RL Mol. Membr. Biol. 30:327-337(2013).
RN [13]
RP X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS), AND SUBUNIT.
RX PubMed=7664082; DOI=10.1038/nsb0894-538;
RA Umland T.C., Swaminathan S., Singh G., Warty V., Furey W., Pletcher J.,
RA Sax M.;
RT "Structure of a human Clara cell phospholipid-binding protein-ligand
RT complex at 1.9-A resolution.";
RL Nat. Struct. Biol. 1:538-545(1994).
CC -!- FUNCTION: Binds phosphatidylcholine, phosphatidylinositol,
CC polychlorinated biphenyls (PCB) and weakly progesterone, potent
CC inhibitor of phospholipase A2.
CC -!- SUBUNIT: Antiparallel homodimer; disulfide-linked (PubMed:7664082).
CC Interaction with LMBR1L has been observed in PubMed:16423471, but not
CC in PubMed:23964685 (PubMed:16423471, PubMed:23964685).
CC {ECO:0000269|PubMed:16423471, ECO:0000269|PubMed:23964685,
CC ECO:0000269|PubMed:7664082}.
CC -!- INTERACTION:
CC P11684; Q13520: AQP6; NbExp=3; IntAct=EBI-7797649, EBI-13059134;
CC P11684; P02751: FN1; NbExp=3; IntAct=EBI-7797649, EBI-1220319;
CC P11684; P01100: FOS; NbExp=3; IntAct=EBI-7797649, EBI-852851;
CC P11684; P50440: GATM; NbExp=3; IntAct=EBI-7797649, EBI-2552594;
CC P11684; Q00613: HSF1; NbExp=3; IntAct=EBI-7797649, EBI-719620;
CC P11684; Q9BTV4: TMEM43; NbExp=3; IntAct=EBI-7797649, EBI-721293;
CC P11684; Q13049: TRIM32; NbExp=8; IntAct=EBI-7797649, EBI-742790;
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Clara cells (nonciliated cells of the surface
CC epithelium of the pulmonary airways).
CC -!- SIMILARITY: Belongs to the secretoglobin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X13197; CAA31584.1; -; mRNA.
DR EMBL; U01101; AAA81885.1; -; mRNA.
DR EMBL; U01102; AAA18297.1; -; Genomic_DNA.
DR EMBL; CR541780; CAG46579.1; -; mRNA.
DR EMBL; AK312165; BAG35099.1; -; mRNA.
DR EMBL; CH471076; EAW74018.1; -; Genomic_DNA.
DR EMBL; BC004481; AAH04481.1; -; mRNA.
DR EMBL; X59875; CAA42532.1; -; Genomic_DNA.
DR CCDS; CCDS8020.1; -.
DR PIR; JS0036; JS0036.
DR PIR; S26651; S26651.
DR RefSeq; NP_003348.1; NM_003357.4.
DR AlphaFoldDB; P11684; -.
DR SMR; P11684; -.
DR BioGRID; 113203; 13.
DR IntAct; P11684; 11.
DR MINT; P11684; -.
DR STRING; 9606.ENSP00000278282; -.
DR DrugBank; DB08373; 4,4'-BIS([H]METHYLSULFONYL)-2,2',5,5'-TETRACHLOROBIPHENYL.
DR iPTMnet; P11684; -.
DR PhosphoSitePlus; P11684; -.
DR BioMuta; SCGB1A1; -.
DR DMDM; 112672; -.
DR jPOST; P11684; -.
DR MassIVE; P11684; -.
DR MaxQB; P11684; -.
DR PaxDb; P11684; -.
DR PeptideAtlas; P11684; -.
DR PRIDE; P11684; -.
DR ProteomicsDB; 52798; -.
DR Antibodypedia; 14807; 475 antibodies from 37 providers.
DR DNASU; 7356; -.
DR Ensembl; ENST00000278282.3; ENSP00000278282.2; ENSG00000149021.7.
DR GeneID; 7356; -.
DR KEGG; hsa:7356; -.
DR MANE-Select; ENST00000278282.3; ENSP00000278282.2; NM_003357.5; NP_003348.1.
DR UCSC; uc001ntj.4; human.
DR CTD; 7356; -.
DR DisGeNET; 7356; -.
DR GeneCards; SCGB1A1; -.
DR HGNC; HGNC:12523; SCGB1A1.
DR HPA; ENSG00000149021; Tissue enriched (lung).
DR MIM; 192020; gene.
DR neXtProt; NX_P11684; -.
DR OpenTargets; ENSG00000149021; -.
DR PharmGKB; PA34989; -.
DR VEuPathDB; HostDB:ENSG00000149021; -.
DR eggNOG; ENOG502SXFT; Eukaryota.
DR GeneTree; ENSGT00940000155073; -.
DR HOGENOM; CLU_166234_1_0_1; -.
DR InParanoid; P11684; -.
DR OMA; MKIAITI; -.
DR OrthoDB; 1608982at2759; -.
DR PhylomeDB; P11684; -.
DR TreeFam; TF338407; -.
DR PathwayCommons; P11684; -.
DR SignaLink; P11684; -.
DR BioGRID-ORCS; 7356; 13 hits in 1075 CRISPR screens.
DR ChiTaRS; SCGB1A1; human.
DR GeneWiki; Uteroglobin; -.
DR GenomeRNAi; 7356; -.
DR Pharos; P11684; Tbio.
DR PRO; PR:P11684; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; P11684; protein.
DR Bgee; ENSG00000149021; Expressed in bronchial epithelial cell and 116 other tissues.
DR ExpressionAtlas; P11684; baseline and differential.
DR Genevisible; P11684; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
DR GO; GO:0005791; C:rough endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR GO; GO:0019834; F:phospholipase A2 inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0097160; F:polychlorinated biphenyl binding; IEA:Ensembl.
DR GO; GO:0007566; P:embryo implantation; TAS:ProtInc.
DR GO; GO:0007565; P:female pregnancy; NAS:ProtInc.
DR GO; GO:0032689; P:negative regulation of interferon-gamma production; IEA:Ensembl.
DR GO; GO:0032696; P:negative regulation of interleukin-13 production; IEA:Ensembl.
DR GO; GO:0032713; P:negative regulation of interleukin-4 production; IEA:Ensembl.
DR GO; GO:0032714; P:negative regulation of interleukin-5 production; IEA:Ensembl.
DR GO; GO:0042130; P:negative regulation of T cell proliferation; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0050727; P:regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0043488; P:regulation of mRNA stability; IEA:Ensembl.
DR GO; GO:0034097; P:response to cytokine; IEA:Ensembl.
DR GO; GO:0071774; P:response to fibroblast growth factor; IEA:Ensembl.
DR GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
DR GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
DR GO; GO:0010193; P:response to ozone; IEA:Ensembl.
DR GO; GO:0034021; P:response to silicon dioxide; IEA:Ensembl.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; NAS:ProtInc.
DR GO; GO:0042098; P:T cell proliferation; IEA:Ensembl.
DR CDD; cd00633; Secretoglobin; 1.
DR InterPro; IPR016126; Secretoglobin.
DR InterPro; IPR043215; Secretoglobin_1C-like.
DR InterPro; IPR035960; Secretoglobin_sf.
DR InterPro; IPR000329; Uteroglobin.
DR PANTHER; PTHR10136; PTHR10136; 1.
DR Pfam; PF01099; Uteroglobin; 1.
DR PRINTS; PR00486; UTEROGLOBIN.
DR SUPFAM; SSF48201; SSF48201; 1.
DR PROSITE; PS51311; SCGB; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Phospholipase A2 inhibitor;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000269|PubMed:11788998,
FT ECO:0000269|PubMed:1395029, ECO:0000269|PubMed:1400743"
FT CHAIN 22..91
FT /note="Uteroglobin"
FT /id="PRO_0000036365"
FT DISULFID 24
FT /note="Interchain (with C-90)"
FT DISULFID 90
FT /note="Interchain (with C-24)"
FT VARIANT 56
FT /note="R -> G (in dbSNP:rs1802634)"
FT /id="VAR_012045"
FT VARIANT 68
FT /note="T -> A (in dbSNP:rs1802632)"
FT /id="VAR_012046"
FT CONFLICT 24
FT /note="C -> E (in Ref. 10; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 91 AA; 9994 MW; FE65ACA678F12ABD CRC64;
MKLAVTLTLV TLALCCSSAS AEICPSFQRV IETLLMDTPS SYEAAMELFS PDQDMREAGA
QLKKLVDTLP QKPRESIIKL MEKIAQSSLC N
