ID   UTER_MACFU              Reviewed;          70 AA.
AC   Q9TS45;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Uteroglobin;
DE   AltName: Full=Clara cell phospholipid-binding protein;
DE            Short=CCPBP;
DE   AltName: Full=Clara cells 10 kDa secretory protein;
DE            Short=CC10;
DE   AltName: Full=Secretoglobin family 1A member 1;
GN   Name=SCGB1A1; Synonyms=CC10, UGB;
OS   Macaca fuscata fuscata (Japanese macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9543;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Lung;
RX   PubMed=8810640; DOI=10.1165/ajrcmb.15.3.8810640;
RA   Hashimoto S., Nakagawa K., Sueishi K.;
RT   "Monkey Clara cell 10 kDa protein (CC10): a characterization of the amino
RT   acid sequence with an evolutional comparison with humans, rabbits, rats,
RT   and mice.";
RL   Am. J. Respir. Cell Mol. Biol. 15:361-366(1996).
CC   -!- FUNCTION: Binds phosphatidylcholine, phosphatidylinositol,
CC       polychlorinated biphenyls (PCB) and weakly progesterone, potent
CC       inhibitor of phospholipase A2.
CC   -!- SUBUNIT: Antiparallel homodimer; disulfide-linked (By similarity).
CC       Interaction with LMBR1L is controversial (By similarity).
CC       {ECO:0000250|UniProtKB:P11684}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Clara cells (nonciliated cells of the surface
CC       epithelium of the pulmonary airways).
CC   -!- SIMILARITY: Belongs to the secretoglobin family. {ECO:0000305}.
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DR   AlphaFoldDB; Q9TS45; -.
DR   SMR; Q9TS45; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019834; F:phospholipase A2 inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd00633; Secretoglobin; 1.
DR   InterPro; IPR016126; Secretoglobin.
DR   InterPro; IPR043215; Secretoglobin_1C-like.
DR   InterPro; IPR035960; Secretoglobin_sf.
DR   InterPro; IPR000329; Uteroglobin.
DR   PANTHER; PTHR10136; PTHR10136; 1.
DR   Pfam; PF01099; Uteroglobin; 1.
DR   PRINTS; PR00486; UTEROGLOBIN.
DR   SUPFAM; SSF48201; SSF48201; 1.
DR   PROSITE; PS51311; SCGB; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Phospholipase A2 inhibitor;
KW   Secreted.
FT   CHAIN           1..70
FT                   /note="Uteroglobin"
FT                   /id="PRO_0000188083"
FT   DISULFID        3
FT                   /note="Interchain (with C-69)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        69
FT                   /note="Interchain (with C-3)"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   70 AA;  7766 MW;  6B072DE53FB37EF7 CRC64;
     EICPTFLRVI ESLFLDTPSS FEAAMGFFSP DQDMSEAGAQ LKKVLDTLPA KARDSIIKLM
     EKIDKSLLCN