UTER_MOUSE
ID UTER_MOUSE Reviewed; 96 AA.
AC Q06318;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=Uteroglobin;
DE AltName: Full=Clara cell 17 kDa protein;
DE AltName: Full=Clara cell phospholipid-binding protein;
DE Short=CCPBP;
DE AltName: Full=Clara cells 10 kDa secretory protein;
DE Short=CC10;
DE AltName: Full=PCB-binding protein;
DE AltName: Full=Secretoglobin family 1A member 1;
DE Flags: Precursor;
GN Name=Scgb1a1; Synonyms=Cc10, Ugb, Utg;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Lung;
RX PubMed=8398159; DOI=10.1165/ajrcmb/9.3.231;
RA Margraf L.R., Finegold M.J., Stanley L.A., Major A., Hawkins H.K.,
RA DeMayo F.J.;
RT "Cloning and tissue-specific expression of the cDNA for the mouse Clara
RT cell 10 kD protein: comparison of endogenous expression to rabbit
RT uteroglobin promoter-driven transgene expression.";
RL Am. J. Respir. Cell Mol. Biol. 9:231-238(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8020953; DOI=10.1006/geno.1994.1123;
RA Stripp B.R., Huffman J.A., Bohinski R.J.;
RT "Structure and regulation of the murine Clara cell secretory protein
RT gene.";
RL Genomics 20:27-35(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 22 AND 25-35.
RC TISSUE=Lung;
RX PubMed=8440203; DOI=10.3109/01902149309071081;
RA Singh G., Katyal S.L., Brown W.E., Kennedy A.L.;
RT "Mouse Clara cell 10-kDa (CC10) protein: cDNA nucleotide sequence and
RT molecular basis for the variation in progesterone binding of CC10 from
RT different species.";
RL Exp. Lung Res. 19:67-75(1993).
RN [4]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=129/Sv; TISSUE=Lung;
RX PubMed=7916613; DOI=10.1006/bbrc.1993.2455;
RA Ray M.K., Magdaleno S., O'Malley B.W., Demayo F.J.;
RT "Cloning and characterization of the mouse Clara cell specific 10 kDa
RT protein gene: comparison of the 5'-flanking region with the human rat and
RT rabbit gene.";
RL Biochem. Biophys. Res. Commun. 197:163-171(1993).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Binds phosphatidylcholine, phosphatidylinositol,
CC polychlorinated biphenyls (PCB) and weakly progesterone, potent
CC inhibitor of phospholipase A2.
CC -!- SUBUNIT: Antiparallel homodimer; disulfide-linked (By similarity).
CC Interaction with LMBR1L is controversial (By similarity).
CC {ECO:0000250|UniProtKB:P11684}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Clara cells (nonciliated cells of the surface
CC epithelium of the pulmonary airways).
CC -!- DEVELOPMENTAL STAGE: Appears on the eighteenth day of gestation in the
CC airway epithelium.
CC -!- INDUCTION: By glucocorticoids.
CC -!- SIMILARITY: Belongs to the secretoglobin family. {ECO:0000305}.
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DR EMBL; L04503; AAA03625.1; -; mRNA.
DR EMBL; L24372; AAA65446.1; -; Genomic_DNA.
DR EMBL; X67702; CAA47936.1; -; mRNA.
DR EMBL; U01247; AAA16141.1; -; Unassigned_DNA.
DR EMBL; BC027518; AAH27518.1; -; mRNA.
DR CCDS; CCDS37911.1; -.
DR PIR; A53025; UGMS.
DR RefSeq; NP_035811.1; NM_011681.2.
DR AlphaFoldDB; Q06318; -.
DR SMR; Q06318; -.
DR STRING; 10090.ENSMUSP00000025554; -.
DR PhosphoSitePlus; Q06318; -.
DR CPTAC; non-CPTAC-3520; -.
DR PaxDb; Q06318; -.
DR PeptideAtlas; Q06318; -.
DR PRIDE; Q06318; -.
DR ProteomicsDB; 275398; -.
DR Antibodypedia; 14807; 475 antibodies from 37 providers.
DR DNASU; 22287; -.
DR Ensembl; ENSMUST00000025554; ENSMUSP00000025554; ENSMUSG00000024653.
DR GeneID; 22287; -.
DR KEGG; mmu:22287; -.
DR UCSC; uc008gom.1; mouse.
DR CTD; 7356; -.
DR MGI; MGI:98919; Scgb1a1.
DR VEuPathDB; HostDB:ENSMUSG00000024653; -.
DR eggNOG; ENOG502SXFT; Eukaryota.
DR GeneTree; ENSGT00940000155073; -.
DR HOGENOM; CLU_166234_1_0_1; -.
DR InParanoid; Q06318; -.
DR OMA; MKIAITI; -.
DR OrthoDB; 1608982at2759; -.
DR PhylomeDB; Q06318; -.
DR TreeFam; TF338407; -.
DR BioGRID-ORCS; 22287; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Scgb1a1; mouse.
DR PRO; PR:Q06318; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q06318; protein.
DR Bgee; ENSMUSG00000024653; Expressed in right lung lobe and 51 other tissues.
DR ExpressionAtlas; Q06318; baseline and differential.
DR Genevisible; Q06318; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0005635; C:nuclear envelope; ISO:MGI.
DR GO; GO:0005791; C:rough endoplasmic reticulum; ISO:MGI.
DR GO; GO:0030141; C:secretory granule; ISO:MGI.
DR GO; GO:0019834; F:phospholipase A2 inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0097160; F:polychlorinated biphenyl binding; ISO:MGI.
DR GO; GO:0032689; P:negative regulation of interferon-gamma production; IDA:MGI.
DR GO; GO:0032696; P:negative regulation of interleukin-13 production; IDA:MGI.
DR GO; GO:0032713; P:negative regulation of interleukin-4 production; IDA:MGI.
DR GO; GO:0032714; P:negative regulation of interleukin-5 production; IDA:MGI.
DR GO; GO:0042130; P:negative regulation of T cell proliferation; IDA:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0050727; P:regulation of inflammatory response; IDA:MGI.
DR GO; GO:0043488; P:regulation of mRNA stability; IDA:MGI.
DR GO; GO:0034097; P:response to cytokine; ISO:MGI.
DR GO; GO:0071774; P:response to fibroblast growth factor; IEA:Ensembl.
DR GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
DR GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
DR GO; GO:0010193; P:response to ozone; IEA:Ensembl.
DR GO; GO:0034021; P:response to silicon dioxide; IEA:Ensembl.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR GO; GO:0042098; P:T cell proliferation; IDA:MGI.
DR CDD; cd00633; Secretoglobin; 1.
DR InterPro; IPR016126; Secretoglobin.
DR InterPro; IPR043215; Secretoglobin_1C-like.
DR InterPro; IPR035960; Secretoglobin_sf.
DR InterPro; IPR000329; Uteroglobin.
DR PANTHER; PTHR10136; PTHR10136; 1.
DR Pfam; PF01099; Uteroglobin; 1.
DR PRINTS; PR00486; UTEROGLOBIN.
DR SUPFAM; SSF48201; SSF48201; 1.
DR PROSITE; PS51311; SCGB; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Phospholipase A2 inhibitor;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..96
FT /note="Uteroglobin"
FT /id="PRO_0000036366"
FT DISULFID 24
FT /note="Interchain (with C-90)"
FT /evidence="ECO:0000250"
FT DISULFID 90
FT /note="Interchain (with C-24)"
FT /evidence="ECO:0000250"
SQ SEQUENCE 96 AA; 10519 MW; 21103A8839497E6C CRC64;
MKIAITITVV MLSICCSSAS SDICPGFLQV LEALLMESES GYVASLKPFN PGSDLQNAGT
QLKRLVDTLP QETRINIMKL TEKILTSPLC KQDLRF
