UTH1_CANAL
ID UTH1_CANAL Reviewed; 372 AA.
AC Q5AKU5; A0A1D8PFU0;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=Secreted beta-glucosidase SIM1;
DE EC=3.2.1.-;
DE Flags: Precursor;
GN Name=SIM1; Synonyms=SUN42, UTH1; OrderedLocusNames=CAALFM_C113940WA;
GN ORFNames=CaO19.12499, CaO19.5032;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP INDUCTION.
RX PubMed=15189998; DOI=10.1128/ec.3.3.776-784.2004;
RA Lotz H., Sohn K., Brunner H., Muhlschlegel F.A., Rupp S.;
RT "RBR1, a novel pH-regulated cell wall gene of Candida albicans, is
RT repressed by RIM101 and activated by NRG1.";
RL Eukaryot. Cell 3:776-784(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RX PubMed=17905924; DOI=10.1128/ec.00285-07;
RA Hiller E., Heine S., Brunner H., Rupp S.;
RT "Candida albicans Sun41p, a putative glycosidase, is involved in
RT morphogenesis, cell wall biogenesis, and biofilm formation.";
RL Eukaryot. Cell 6:2056-2065(2007).
RN [6]
RP INDUCTION.
RX PubMed=17164403; DOI=10.1074/mcp.m600210-mcp200;
RA Fernandez-Arenas E., Cabezon V., Bermejo C., Arroyo J., Nombela C.,
RA Diez-Orejas R., Gil C.;
RT "Integrated proteomics and genomics strategies bring new insight into
RT Candida albicans response upon macrophage interaction.";
RL Mol. Cell. Proteomics 6:460-478(2007).
RN [7]
RP FUNCTION.
RX PubMed=18001349; DOI=10.1111/j.1365-2958.2007.06011.x;
RA Firon A., Aubert S., Iraqui I., Guadagnini S., Goyard S., Prevost M.C.,
RA Janbon G., d'Enfert C.;
RT "The SUN41 and SUN42 genes are essential for cell separation in Candida
RT albicans.";
RL Mol. Microbiol. 66:1256-1275(2007).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RX PubMed=18227255; DOI=10.1099/mic.0.2007/012617-0;
RA Sosinska G.J., de Groot P.W., Teixeira de Mattos M.J., Dekker H.L.,
RA de Koster C.G., Hellingwerf K.J., Klis F.M.;
RT "Hypoxic conditions and iron restriction affect the cell-wall proteome of
RT Candida albicans grown under vagina-simulative conditions.";
RL Microbiology 154:510-520(2008).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RX PubMed=21622905; DOI=10.1128/ec.05011-11;
RA Sorgo A.G., Heilmann C.J., Dekker H.L., Bekker M., Brul S., de Koster C.G.,
RA de Koning L.J., Klis F.M.;
RT "Effects of fluconazole on the secretome, the wall proteome, and wall
RT integrity of the clinical fungus Candida albicans.";
RL Eukaryot. Cell 10:1071-1081(2011).
RN [10]
RP INDUCTION.
RX PubMed=22265407; DOI=10.1016/j.cell.2011.10.048;
RA Nobile C.J., Fox E.P., Nett J.E., Sorrells T.R., Mitrovich Q.M.,
RA Hernday A.D., Tuch B.B., Andes D.R., Johnson A.D.;
RT "A recently evolved transcriptional network controls biofilm development in
RT Candida albicans.";
RL Cell 148:126-138(2012).
CC -!- FUNCTION: Cell surface beta-glucosidase involved in cell wall
CC maintenance and cytokinesis. Plays a role redundant to SUN41.
CC {ECO:0000269|PubMed:18001349}.
CC -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000269|PubMed:17905924,
CC ECO:0000269|PubMed:18227255, ECO:0000269|PubMed:21622905}.
CC -!- INDUCTION: Expression is up-regulated during biofilm formation and
CC down-regulated by RIM101, CYR1, RAS1, as well as by host macrophages.
CC {ECO:0000269|PubMed:15189998, ECO:0000269|PubMed:17164403,
CC ECO:0000269|PubMed:22265407}.
CC -!- SIMILARITY: Belongs to the SUN family. {ECO:0000305}.
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DR EMBL; CP017623; AOW26995.1; -; Genomic_DNA.
DR RefSeq; XP_722234.1; XM_717141.1.
DR AlphaFoldDB; Q5AKU5; -.
DR STRING; 237561.Q5AKU5; -.
DR GeneID; 3636185; -.
DR KEGG; cal:CAALFM_C113940WA; -.
DR CGD; CAL0000182747; SIM1.
DR VEuPathDB; FungiDB:C1_13940W_A; -.
DR eggNOG; ENOG502QREM; Eukaryota.
DR HOGENOM; CLU_033459_2_0_1; -.
DR InParanoid; Q5AKU5; -.
DR OMA; CIWGTEG; -.
DR OrthoDB; 1130819at2759; -.
DR PRO; PR:Q5AKU5; -.
DR Proteomes; UP000000559; Chromosome 1.
DR GO; GO:0009986; C:cell surface; IDA:CGD.
DR GO; GO:0005576; C:extracellular region; IDA:CGD.
DR GO; GO:0009277; C:fungal-type cell wall; IDA:CGD.
DR GO; GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.
DR GO; GO:0031505; P:fungal-type cell wall organization; IBA:GO_Central.
DR GO; GO:0000272; P:polysaccharide catabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006275; P:regulation of DNA replication; NAS:CGD.
DR InterPro; IPR005556; SUN.
DR Pfam; PF03856; SUN; 1.
PE 1: Evidence at protein level;
KW Carbohydrate metabolism; Cell wall; Cell wall biogenesis/degradation;
KW Glycoprotein; Glycosidase; Hydrolase; Polysaccharide degradation;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..15
FT /evidence="ECO:0000255"
FT CHAIN 16..372
FT /note="Secreted beta-glucosidase SIM1"
FT /id="PRO_0000428631"
FT REGION 51..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 54
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 351
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 372 AA; 39381 MW; 4F25702B78F6D4E8 CRC64;
MKYLTLLTVL STALATPLQH QHHHHHEHAR RAEVTKVVYV NGNGDEVQSQ VTENASSGAS
SGETAETIQT RSSSDVSSSS DSNPVASIAS SVASSASSIL SNIEGDLSAF SSPSKKFEDG
VYDCDSVPVG QGVIGVDWIS GLNGGWTTIM NENGDTSLNC KDGYYCSYAC QAGMSKTQWP
SEQPSNGMSI GGLYCKNGKL YRSNTDNDYL CEWGSKDVNF VSEISEDVAI CRTDYPGSEN
MNIPTLLSAG GKAPCSVVDG DTYFKWQGGK TSTQYYVNNA GVSVEDGCIW GTEGSGVGNW
APVVLGSGTT GGKTYLSLIP NPNNKDKPNY NIKIVGDDVN GDCKYENGQY NGSGSDGCTV
TVNSGSAKFV FY
