ID   UTMP_SHEEP              Reviewed;         429 AA.
AC   P21814;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 2.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Uterine milk protein;
DE            Short=UTMP;
DE   Flags: Precursor;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 26-54.
RX   PubMed=2464597; DOI=10.1016/s0021-9258(18)94076-7;
RA   Ing N.H., Roberts R.M.;
RT   "The major progesterone-modulated proteins secreted into the sheep uterus
RT   are members of the serpin superfamily of serine protease inhibitors.";
RL   J. Biol. Chem. 264:3372-3379(1989).
CC   -!- TISSUE SPECIFICITY: Secreted by ovine endometrium under the influence
CC       of progesterone.
CC   -!- PTM: Glycosylated; carries the so-called mannose 6-phosphate lysosomal
CC       recognition marker on its carbohydrate chains.
CC   -!- SIMILARITY: Belongs to the serpin family. UTMP subfamily.
CC       {ECO:0000305}.
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DR   EMBL; M21027; AAA31587.1; -; mRNA.
DR   PIR; A33309; A33309.
DR   RefSeq; NP_001009304.1; NM_001009304.1.
DR   AlphaFoldDB; P21814; -.
DR   SMR; P21814; -.
DR   STRING; 9940.ENSOARP00000016059; -.
DR   MEROPS; I04.981; -.
DR   PRIDE; P21814; -.
DR   GeneID; 443315; -.
DR   KEGG; oas:443315; -.
DR   CTD; 612383; -.
DR   eggNOG; KOG2392; Eukaryota.
DR   OrthoDB; 1124079at2759; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0030414; F:peptidase inhibitor activity; IDA:CACAO.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007565; P:female pregnancy; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.39.10; -; 1.
DR   Gene3D; 3.30.497.10; -; 1.
DR   InterPro; IPR023795; Serpin_CS.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461; PTHR11461; 2.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; SSF56574; 1.
DR   PROSITE; PS00284; SERPIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Glycoprotein; Pregnancy; Protease inhibitor;
KW   Reference proteome; Serine protease inhibitor; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000269|PubMed:2464597"
FT   CHAIN           26..429
FT                   /note="Uterine milk protein"
FT                   /id="PRO_0000032532"
FT   SITE            390..391
FT                   /note="Reactive bond"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        222
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        268
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        49
FT                   /note="K -> R (in Ref. 1; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        53
FT                   /note="H -> L (in Ref. 1; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   429 AA;  49223 MW;  39CB19C4ADA0E95F CRC64;
     MSHRRMQLAL SLVFILCGLF NSIFCEKQQH SQQHANLVLL KKISAFSQKM EAHPKAFAQE
     LFKALIAENP KKNIIFSPAA MTITLATLSL GIKSTMSTNH PEDLELELKL LDAHKCLHHL
     VHLGRELVKQ KQLRHQDILF LNSKMMANQM LLHQIRKLQK MDIQMIDFSD TEKAKKAISH
     HVAEKTHTKI RDLITDLNPE TILCLVNHIF FKGILKRAFQ PNLTQKEDFF LNDKTKVQVD
     MMRKTEQMLY SRSEELFATM VKMPFKGNVS LILMLPDAGH FDNALKKLTA KRAKLQKISN
     FRLVHLTLPK FKITFDINFK HLLPKINLKH LLPKIDPKHT LTTTASSQHV TLKAPLPNLE
     ALHQVEIELS EHALTTDTAI HTDNLLKVPA NTKEVPVVVK FNRPFLLFVE DEITQTDLFV
     GQVLNPQVE