UTP10_ASHGO
ID UTP10_ASHGO Reviewed; 1774 AA.
AC Q754J8;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=U3 small nucleolar RNA-associated protein 10;
GN Name=UTP10 {ECO:0000250|UniProtKB:P42945}; OrderedLocusNames=AFR074C;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1] {ECO:0000312|EMBL:AAS53445.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC Involved in ribosome biosynthesis (By similarity).
CC {ECO:0000250|UniProtKB:P42945}.
CC -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome.
CC {ECO:0000250|UniProtKB:P42945}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:P42945}.
CC -!- SIMILARITY: Belongs to the HEATR1/UTP10 family. {ECO:0000305}.
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DR EMBL; AE016819; AAS53445.1; -; Genomic_DNA.
DR RefSeq; NP_985621.1; NM_210975.2.
DR AlphaFoldDB; Q754J8; -.
DR SMR; Q754J8; -.
DR STRING; 33169.AAS53445; -.
DR PRIDE; Q754J8; -.
DR EnsemblFungi; AAS53445; AAS53445; AGOS_AFR074C.
DR GeneID; 4621863; -.
DR KEGG; ago:AGOS_AFR074C; -.
DR eggNOG; KOG1837; Eukaryota.
DR HOGENOM; CLU_001128_3_1_1; -.
DR InParanoid; Q754J8; -.
DR OMA; YTNQLLF; -.
DR Proteomes; UP000000591; Chromosome VI.
DR GO; GO:0030686; C:90S preribosome; IBA:GO_Central.
DR GO; GO:0030688; C:preribosome, small subunit precursor; IEA:EnsemblFungi.
DR GO; GO:0033553; C:rDNA heterochromatin; IEA:EnsemblFungi.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0034455; C:t-UTP complex; IBA:GO_Central.
DR GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR GO; GO:0034511; F:U3 snoRNA binding; IEA:EnsemblFungi.
DR GO; GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR GO; GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR012954; BP28_C_dom.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR022125; U3snoRNP10_N.
DR InterPro; IPR040191; UTP10.
DR PANTHER; PTHR13457; PTHR13457; 1.
DR Pfam; PF08146; BP28CT; 1.
DR Pfam; PF12397; U3snoRNP10; 1.
DR SMART; SM01036; BP28CT; 1.
DR SUPFAM; SSF48371; SSF48371; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW Ribosome biogenesis; rRNA processing.
FT CHAIN 1..1774
FT /note="U3 small nucleolar RNA-associated protein 10"
FT /id="PRO_0000308492"
FT REPEAT 1734..1772
FT /note="HEAT"
FT /evidence="ECO:0000255"
FT REGION 1209..1228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1774 AA; 198396 MW; F8C6812F27DA1420 CRC64;
MSSLKEQLAQ VAASNATVAL DRKRRQKLHS ASLIYNPKTA ATQDYDFIFD NATSALEELV
EIDVRFKVFS RSLFSASSVN IDRNTQTKEQ VRTLDQAVNA YLMLASAWWH LTPTLHATEW
LVRRFQIHVH NAEMLLLSTL NYYQSPVFKR ILNIVKLPPL FSSLANFAKA ESVPSNLTIV
KLFNDMDFLT LYTSYVGKVV KQKVTYTNQL LFNSCAFINL VAFNSNSEEK LERLVPILLE
VCAKLLASPS DDCQMAAHTV LVVLVTALPL KKQILLAATE TILANLADSA STKRCAFVTV
CKLFQTLKGH GNVDQLPANI YTLFDSKISN DCLIDFLSKK ETPADKFVTS YVRSIARYDH
GKLNSIVSIL KQVKLEKFEV RLIITDLIHL SELLEDKSQL IQLFEFFISI DEDMVLRCLH
SLNLTGELFE IRLTTSLFSA ERIEPVNGED VVKGLEASKV AGLAGGAQPF TEFLNKNSAY
ICTKNISLLV EDDEQASKLL SLFVESVGKK YQPGLFLSSF FTTLESRITF LLRIIVSPGA
PVALRLISVS NLSKLIHTIG NDTNVFTLVP VLIVALTDIS KNVRAAVKKV LHQISKRPFT
KRYFLNDKIY GEGQSVPMLN PKESESWLKT FLDGYLVENY DISQLLIPKK NEKMYLLFWA
NQALYMPLPQ PKLVLMRFLA RHESFSSTYS QLWENFLSSY LEQRPQWELK CSKNKTNFCE
FESVLVLLLS KKEKNPAAIE FLLGALKSPF EQLASIMAKR LIEIYPTLKQ PVQCQIVQDI
IESTASADLS YDSIETLQSL ALSADVVVSV IKQNMINVDE TSNIIKKRRR RSSASNKAAL
QKEEVSRIAE IHLRKLTILL EALDKIKVQG SEALLTSLFD ILADLDTLDN DGGLPVLYAQ
ETLASCMLHT IDSLRATGAT PKLRSVRTDI LVAAIRASSS PQVQNKLLLV ISALALLNPE
LVLHSIMPIF TFMGAHSLRQ DDEFSTMVVE KTVKTVVPAL LESGSSSMTD EIEFLLMSFS
TAFSHVPKHR RVRLFTTLIK TLQPSSSIAP FLFLLSQQFS AKVENFEIAE SKSILEFSRS
FMSKFAVLDQ LTGIAGLFEL VKLLSEPDLK DKTSPRTLLS NGILNYTPSE MFNYKRNTFD
FMDKILAEDN QGGNKGENNL KLKLLSALLD PQTEEQVKSD VKDQFAKVLQ HNLVFINNVE
ELCSTQDLTE QGKSDGDESG SEPDNDNPVA DMTEILFSLL GHILDLLPIS TFVESILPLL
GKDTEDIIRK HLTLVIGTKF ESEPNSSATY ANMTASSLLA IVTDEAEAPG VVQAALNTTS
TLVSKFGDRL DASTLTECLK IGVQKLNSSS TDIVVSALAV LTNTVHVLGV KSIGFYAKIV
PRALAIFDSV QDTKSDLRKE VQLSVVLLFA AMMKRIPSFL QSNLKDVMRA IFFADEVQNS
ISLYVISLLV QQLDLKEVLK TLYRIWTTDI SKTGNSVAVS LFLTTLESTV EAIDKKSATS
QSPTFFKLLL AMFEYRSVST FDNNTISRIE ASVHQIANIY VLKLNDKIFR PLFALTVRWA
FDGESVSNLQ ITKVERLTAF FKFFNKLQES LKSIITSYFT YLLEPTNALL NDFHSGAVSD
TNLRRLTLTA LTASFKYDRD EYWKSTARFE LLAESLVNQL ANIEDSIGKY LVKAIAALAS
NNAGVDEHSK LLHRALVEHM KASCATSQKL WAVKATKLIY AKVGEHWLVL LPQLVPVIAE
LLEDDDEEVE QEVRTGLVKV VETVLGEPFD RYLT
