UTP10_ASPCL
ID UTP10_ASPCL Reviewed; 1819 AA.
AC A1CUH7;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=U3 small nucleolar RNA-associated protein 10;
GN Name=utp10 {ECO:0000250|UniProtKB:P42945}; ORFNames=ACLA_086630;
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC Involved in ribosome biosynthesis (By similarity).
CC {ECO:0000250|UniProtKB:P42945}.
CC -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome.
CC {ECO:0000250|UniProtKB:P42945}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:P42945,
CC ECO:0000255}. Membrane {ECO:0000255}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the HEATR1/UTP10 family. {ECO:0000305}.
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DR EMBL; DS027060; EAW06964.1; -; Genomic_DNA.
DR RefSeq; XP_001268390.1; XM_001268389.1.
DR AlphaFoldDB; A1CUH7; -.
DR SMR; A1CUH7; -.
DR STRING; 5057.CADACLAP00007313; -.
DR PRIDE; A1CUH7; -.
DR EnsemblFungi; EAW06964; EAW06964; ACLA_086630.
DR GeneID; 4700311; -.
DR KEGG; act:ACLA_086630; -.
DR VEuPathDB; FungiDB:ACLA_086630; -.
DR eggNOG; KOG1837; Eukaryota.
DR HOGENOM; CLU_001128_3_1_1; -.
DR OMA; NDVMWKQ; -.
DR OrthoDB; 524830at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; -; 3.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR012954; BP28_C_dom.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR022125; U3snoRNP10_N.
DR InterPro; IPR040191; UTP10.
DR PANTHER; PTHR13457; PTHR13457; 1.
DR Pfam; PF08146; BP28CT; 1.
DR Pfam; PF12397; U3snoRNP10; 1.
DR SMART; SM01036; BP28CT; 1.
DR SUPFAM; SSF48371; SSF48371; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 2.
PE 3: Inferred from homology;
KW Membrane; Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW Ribosome biogenesis; rRNA processing; Transmembrane; Transmembrane helix.
FT CHAIN 1..1819
FT /note="U3 small nucleolar RNA-associated protein 10"
FT /id="PRO_0000308493"
FT TRANSMEM 945..965
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1001..1021
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 583..620
FT /note="HEAT 1"
FT /evidence="ECO:0000255"
FT REPEAT 1045..1082
FT /note="HEAT 2"
FT /evidence="ECO:0000255"
FT REPEAT 1269..1306
FT /note="HEAT 3"
FT /evidence="ECO:0000255"
FT REPEAT 1313..1351
FT /note="HEAT 4"
FT /evidence="ECO:0000255"
FT REPEAT 1775..1812
FT /note="HEAT 5"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1819 AA; 201152 MW; 7912D6105504D42A CRC64;
MASSLAAQLS QIAAKSTNQL DLKAQRLSHS QSLIFDRKVA GTQDFDTVYQ ICFEGFQELC
QLDARFNSFE RTIFSEQSKT EDRTQLSAAQ NKELDVVLEA FLALVGGRLL LSPAVKAVDW
LIRRFRVHEY NTEFTILTFL PYYTTPLFLN LLSILPEDLT PTFKILIPYK KGLLNPPRHP
LVHSATTNRA FLAAVNNYVL TVSRQQAHHH ALLAFWAGII TEAVAGMLDS SRSGRREVEK
QKHEDIILRI LPILNDGFAL KNVSELVIGC YMVSVVLAQK SSLQDKLLDG LMEAVAGSWT
EETLESGLVC LAVLAQQKPE TRLPRRALKA ILRLDDIVKR LTDISSQYQT SNLLLGVVAG
CVDDLTKHKD TARLELLPRV FQTQLLGELE TSKAMAMVLH AASNAHRDGT MSLDTQACLA
DLVQEFNQSE FLQPIFQKTI AESTFDTAAI EHNLQTVIVT APAPRAVEDV VMGDAEKVVE
QDGFSSTLEA LVGEKLFKSS FLSAQSIPVF DRLVQAFALA ASSEEKTQVF SDLAVLGKSE
VSKSPQYLSF FIRVFSGPYP IGTRAMALNI VATFLTSTSN LDLDFQAILP FLLVALADPS
ERIRREAAAA LAAIGGIYKK HKKGENVWGR DTIYGQEKQS KSVQWLPTRD AQKVFERAVL
PSLEECIFDP GHISKVLETT LRGASVDPNA SELKKPLRLS FFTFLCSHAI QLPLFTPKLG
LLGLLNRIDK AGGTTRTKEL EPLLKAWRGL SEQEVSDICE KQRVPVSEVE SQMVTIVTPK
EKDALTLLLS NVSPYSESLR STFVAAIFAR VKDIWARVSE DRQVLAAEQL FDIALGLSDS
ALVNNCRNLL RSVELPGSVL IEFLEKIPVS LTDMEAVGPA PKRRRTSQSN MIAMTVKDEA
EFGKVMEKMT FILELVDSSS PETHPELADG LFQTLAALHH FKSQIQSGMS YLLSLTLGSL
LAIVNRSKES AKAQFDTSVI RADLVVDCVR TTESPQVQNA ALLLVSGLSV IAPELVLHSV
MPIFTFMGSS VLRKDDEYSV SVIDQTIDQV VPALIQSLRN QKRDVVSGTS ELLLSFTAAF
EHIPSHRRLR LFHALITKLG TQDFLFAVLA MLANRYAMDK DVLVLMTGLV SDASAPVELT
VRRVHFYCGD SFLTKLQTYY KYLDLVTDSL KAKPSISQVL LGIGSDDGRE PQKVAVDLLR
DLAYLFKHSS LKVKMAKAFA SEDEEVIGQI RALFSRILEQ VLTIGDSVQS MKLVGQANSD
VLGALFGTLT LVDFLDTIEV LLQRPSDELR RKVLRLLEGR LRQNPERDGA SQIRVLDFLP
TLVDIVRSSP DILLKHAAVA CIDRIAEKYG KKDPSRVVSA AQVVASEACI GQEDDRIRIM
GVLCLASMAD VLGQAMIPAL PEALSRSLAL LEVSLEKGKE NSRLHDATFS LFSALFVHIP
YMISGPILDQ ILLLSFKSAN AEDCEDDGRQ EALRMMARKV DMAATLGAVD RNWQYAVQAG
PAAAKETLEV VSLAIEKHPK SATGKNIGVL TSILFKVFDL RREQLALGSK ATFEMADIEE
IEESVNDVTI KMIYKLNDST FRPIFTKLQD WAIAGLPKKD TQGSLARLTT FYKFLQVFFG
TLQSIVTGYA SYIIESVVSI LGKASPSDKN TKSLWLATMR LLRSAFEHDQ DEFWQSPSHL
TQISKPLISQ LAHATNSSTA ALVIAEAVPT ITELAIAADS TDNHKDLNTL LMRFLRPSSG
PTGNRVAGGE NPHTRLAALK AEQSLTEQLG EEWLALLPEM LPYISELMED EDENVEREVR
KWVKQIENVL GEKLDDMLT